Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells.

Abstract:

:Bioassay-guided fractionation of the H(2)O extract of the seeds of Psoralea corylifolia furnished one hepatoprotective compound, bakuchiol (1), together with two moderately active compounds, bakuchicin (2) and psoralen (3), on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC(50) values of compounds 1 - 3 are 1.0, 47.0, 50.0 microg/ml, respectively. Silymarin as a positive control showed the EC(50) value with 5.0 microg/ml.

journal_name

Planta Med

journal_title

Planta medica

authors

Cho H,Jun JY,Song EK,Kang KH,Baek HY,Ko YS,Kim YC

doi

10.1055/s-2001-18347

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

750-1

issue

8

eissn

0032-0943

issn

1439-0221

journal_volume

67

pub_type

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