Abstract:
:(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethylperhydro-1,4-oxazine-2,5-dione (1) was isolated from the fruiting bodies of Isaria japonica as an apoptosis-inducing agent. The complete structural assignment of the compound was accomplished on the basis of spectroscopic methods and chemical transformations. Compound 1 induced apoptotic cell death of the human leukemia cells (HL-60) in a dose-dependent manner, ranging from 5.0 microg/ml to 100.0 microg/ml.
journal_name
Planta Medjournal_title
Planta medicaauthors
Oh H,Kim T,Oh GS,Pae HO,Hong KH,Chai KY,Kwon TO,Chung HT,Lee HSdoi
10.1055/s-2002-26744subject
Has Abstractpub_date
2002-04-01 00:00:00pages
345-8issue
4eissn
0032-0943issn
1439-0221journal_volume
68pub_type
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