Effects of Evodia rutaecarpa and rutaecarpine on the pharmacokinetics of caffeine in rats.


:To assess possible herb-drug interactions, rutaecarpine (an herbal ingredient of Evodia rutaecarpa; 25 mg/kg/day, p. o.), the ethanol extract of Evodia rutaecarpa (1 g/kg/day, p. o.), and an herbal preparation of Evodia rutaecarpa (Wu-Chu-Yu-Tang; 1 g/kg/day) were individually pretreated daily for three consecutive days in rats and on the fourth day caffeine was administered (2 mg/kg, i. v.). Caffeine concentrations in blood, brain and bile were concurrently measured by microdialysis coupled to a liquid chromatographic system. Pharmacokinetic data were calculated by a non-compartmental model. The results indicate that the caffeine crosses the blood-brain barrier and goes through hepatobiliary excretion. The caffeine level was significantly decreased by the pretreatment of rutaecarpine, the extract of Evodia rutaecarpa and herbal preparation Wu-Chu-Yu-Tang. This finding should be very important whenever herb-drug interactions would be possible for a herbal remedy.


Planta Med


Planta medica


Tsai TH,Chang CH,Lin LC




Has Abstract


2005-07-01 00:00:00












  • Stimulatory effects of ingenols from Euphorbia kansui on the expression of macrophage Fc receptor.

    abstract::Immune complex binding to macrophages was enhanced by treatment with an E. kansui extract. Systematic fractionation of the extract led to the characterization of 3-O-(2'E,4'Z-decadienoyl)- and 3-O-(2,3-dimethylbutyryl)-13- O-n-dodecanoyl-13-hydroxyingenol as the active principles. Immune complex binding to macrophages...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Matsumoto T,Cyong JC,Yamada H

    更新日期:1992-06-01 00:00:00

  • Protective effect of Labisia pumila on stress-induced behavioral, biochemical, and immunological alterations.

    abstract::The aim of the present study was to investigate the antistress potential of LABISIA PUMILA aqueous extract (LPPM/A003) using a battery of tests widely employed in different stressful situations. Pretreatment of experimental animals with LPPM/A003 caused an increase in the swimming endurance and hypoxia time and also s...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kour K,Sharma N,Chandan BK,Koul S,Sangwan PL,Bani S

    更新日期:2010-10-01 00:00:00

  • Comparative antioxidant, prooxidant and cytotoxic activity of sigmoidin A and eriodictyol.

    abstract::Sigmoidin A (SGN) is a prenylated flavanone derivative of eriodictyol (ERD) with reported moderate antioxidant, antimicrobial and anti-inflammatory activity. Since ERD and other structurally similar antioxidant phenolic compounds have been shown to induce prooxidative macromolecular damage and cytotoxicity in cancer c...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Habtemariam S,Dagne E

    更新日期:2010-04-01 00:00:00

  • Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells.

    abstract::Cnidicin (1) and five related coumarins were isolated from the root extract of Angelica koreana (Umbelliferae) as active principles responsible for the inhibitory effect on the degranulation process of cultured mast cells. Cnidicin (1) demonstrated a significant inhibition upon the release of beta-hexosaminidase from ...

    journal_title:Planta medica

    pub_type: 信件


    authors: Ryu SY,Kou NY,Choi HS,Ryu H,Kim TS,Kim KM

    更新日期:2001-03-01 00:00:00

  • Immobilization of strictosidine synthase from Catharanthus cell cultures and preparative synthesis of strictosidine.

    abstract::Strictosidine synthase was partially purified from Catharanthus roseus cell suspension cultures and immobilized on CNBr-activated Sepharose. The immobilized enzyme exhibits a thermostability increased 300 fold over that of the soluble enzyme and catalyses exclusively the formation of the 3alpha(S)-isomer, strictosidin...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Pfitzner U,Zenk MH

    更新日期:1982-09-01 00:00:00

  • Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships.

    abstract::Three flavonoids: norwogonin, dihydronorwogonin and baicalein, were isolated from the roots of Scutellaria baicalensis, as potential inhibitors of VHR dual-specificity protein tyrosine phosphatase (DS-PTPase). Norwogonin (IC 50 = 1.1 microM), dihydronorwogonin (IC 50 = 2.9 microM) and baicalein (IC 50 = 2.4 microM) sh...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lee MS,Oh WK,Kim BY,Ahn SC,Kang DO,Sohn CB,Osada H,Ahn JS

    更新日期:2002-12-01 00:00:00

  • In vitro antimalarial activity of Coutarea latiflora and Exostema caribaeum extracts on Plasmodium falciparum.

    abstract::The medicinal plants, Coutarea latiflora Sesse & Moc. ex. DC. (Hintonia latiflora Bullock) (Rubiaceae) and Exostema caribaeum (Jacq.) Roem. et Schult. (Rubiaceae) were examined for antimalarial properties. Among different crude solvent extracts of the stem bark, the hydrolysed ethyl acetate extracts were shown to have...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Noster S,Kraus L

    更新日期:1990-02-01 00:00:00

  • Erythrinaline alkaloids and antimicrobial flavonoids from Erythrina latissima.

    abstract::The seed pods of Erythrina latissima yielded erysotrine, erysodine, syringaresinol, vanillic acid, a new erythrina alkaloid, (+)-10,11-dioxoerysotrine, which was lethal to brine shrimp and 2-(5'-hydroxy-3'-methoxy phenyl)-6-hydroxy-5-methoxybenzofuran, which showed strong antimicrobial activity against the yeast spore...

    journal_title:Planta medica

    pub_type: 信件


    authors: Wanjala CC,Juma BF,Bojase G,Gashe BA,Majinda RR

    更新日期:2002-07-01 00:00:00

  • Inhibition of the transcription factor NF-kappa B by sesquiterpene lactones from Podachaenium eminens.

    abstract::Investigation of Podachaenium eminens afforded nine sesquiterpene lactones (Sls) from which costunolide, 7-hydroxycostunolide, santamarin as well as 3-chlorodehydroleucodin are new for this plant and 3,4-dehydro-4-dehydroxypodachaenin (= 3-costoyloxydehydroleucodin) is found for the first time in nature. All isolated ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Castro V,Murillo R,Klaas CA,Meunier C,Mora G,Pahl HL,Merfort I

    更新日期:2000-10-01 00:00:00

  • Antiplasmodial activity of Cryptolepis sanguinolenta alkaloids from leaves and roots.

    abstract::The roots of Cryptolepis sanguinolenta have been investigated for their chemical composition since 1931 but so far no studies on the leaves have been reported although they are used in traditional medicine in Guinea-Bissau. Two new alkaloids identified as cryptolepinoic acid (1) and methyl cryptolepinoate (2) and the ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Paulo A,Gomes ET,Steele J,Warhurst DC,Houghton PJ

    更新日期:2000-02-01 00:00:00

  • Antiviral Activity of Crude Hydroethanolic Extract from Schinus terebinthifolia against Herpes simplex Virus Type 1.

    abstract::Herpes simplex virus infections persist throughout the lifetime of the host and affect more than 80 % of the humans worldwide. The intensive use of available therapeutic drugs has led to undesirable effects, such as drug-resistant strains, prompting the search for new antiherpetic agents. Although diverse bioactivitie...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Nocchi SR,Companhoni MV,de Mello JC,Dias Filho BP,Nakamura CV,Carollo CA,Silva DB,Ueda-Nakamura T

    更新日期:2017-04-01 00:00:00

  • Flavonoids and a sesquiterpene lactone from Tanacetum microphyllum inhibit anti-inflammatory mediators in LPS-stimulated mouse peritoneal macrophages.

    abstract::In our ongoing research into anti-inflammatory compounds from Tanacetum microphyllum, four naturally occurring flavonoids (santin, ermanin, centaureidin and 5,3'-dihydroxy-4'-methoxy-7-methoxycarbonylflavonol) and one sesquiterpene lactone (hydroxyachillin) isolated from this plant, were evaluated as potential inhibit...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Abad MJ,Bermejo P,Alvarez M,Guerra JA,Silván AM,Villar AM

    更新日期:2004-01-01 00:00:00

  • Single-Lab Validation for Determination of Kavalactones and Flavokavains in Piper methysticum (Kava).

    abstract::Piper methysticum (Kava) is a plant whose roots are used in the preparation of traditional beverages with spiritual, medicinal, and social importance for the Pacific Islanders. Kava is also sold as a herbal supplement or recreational beverage consumed for its mild inebriating effect in Europe and North America. With a...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Liu Y,Lund JA,Murch SJ,Brown PN

    更新日期:2018-11-01 00:00:00

  • Rapid qualitative and quantitative determination of seven valuable taxanes from various Taxus species by UFLC-ESI-MS and UFLC-DAD.

    abstract::The distribution and level of yew constituents vary with species and tissues. In this study, a rapid and valid method incorporating ultra-fast liquid chromatography (UFLC) with MS and UV detection was developed for simultaneous determination of paclitaxel and its six semisynthesis precursors in needles and hair roots ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ge GB,Liang SC,Hu Y,Liu XB,Mao YX,Zhang YY,Luan HW,Qiu MH,Yang L

    更新日期:2010-10-01 00:00:00

  • Minor Alkaloids of Corydalis bulbosa, Structure of Bulbodione.

    abstract::As a result of the reinvestigation of the alkaloid content of CORYDALIS BULBOSA (L.) DC. (Papaveraceae), growing in Bulgaria, a new 8,11-dioxoaporphine alkaloid, named bulbodione, together with dihydrosanguinarine, dehydroglaucine, (+/-)-sinactine, glaucinone and bicucullinine were isolated. These six alkaloids had no...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kiryakov HG,Iskrenova ES

    更新日期:1984-04-01 00:00:00

  • Anti HSV-1 flavonoid derivatives tethered with houttuynin from Houttuynia cordata.

    abstract::This paper reports the phytochemical investigation of the 50% aq. EtOH extract of Houttuynia cordata, an effective TCM and functional food in China, which led to the isolation of 17 flavonoids including four new ones. The four new compounds were flavonoid derivatives tethered with houttuynin (3-oxododecanal). Each of ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chen SD,Li T,Gao H,Zhu QC,Lu CJ,Wu HL,Peng T,Yao XS

    更新日期:2013-12-01 00:00:00

  • [New cardioactive drugs II, detection and isolation of cardiotonic amines with ionpair-HPLC].

    abstract::An ionpair-HPLC-technic using a reversed-phase column was developed to screen plant extracts for cardiotonic amines and to isolate them in a preparative scale for direct MS and pharmacological investigations. By this method the positive inotropic tyramine could be isolated from Selenicereus grandiflorus (L.) Britt et ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wagner H,Grevel J

    更新日期:1982-01-01 00:00:00

  • Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies.

    abstract::Ganoderan B increased the plasma insulin level in normal and glucose-loaded mice but elicited no effect on insulin binding to isolated adipocytes. Administration of ganoderan B elicited significant increases of the activities of hepatic glucokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase, decreased ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Hikino H,Ishiyama M,Suzuki Y,Konno C

    更新日期:1989-10-01 00:00:00

  • New xanthone glycosides from Comastoma pedunculatum.

    abstract::Five new xanthone glycosides, comastomasides A-E (1-5), were isolated from aqueous ethanol extracts of the aerial portions of Comastoma pedunculatum. The structures of these compounds were elucidated by spectroscopic analysis methods. Compounds 1-5 were evaluated for their hepatoprotective activity and cytotoxicity ag...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Qiao Y,Yuan Y,Cui B,Zhang Y,Chen H,Li S,Li Y

    更新日期:2012-09-01 00:00:00

  • In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists.

    abstract::Ginsenosides are the major principles of Panax ginseng C. A. Meyer (Araliaceae) used as a mild oriental folk medicine. In this report, we have examined the inhibitory potency of protopanaxadiol ginsenosides (PPDGs) such as Rb1, Rb2 and Rc, and their co-treatment effect with known tumor necrosis factor (TNF)-alpha anta...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Cho JY,Yoo ES,Baik KU,Park MH,Han BH

    更新日期:2001-04-01 00:00:00

  • Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis.

    abstract::Four diterpenoids, carnosic acid (1), carnosol (2), rosmanol (3), and epirosmanol (4), were isolated as antioxidative agents from the leaves of Rosmarinus officinalis by bioassay-directed fractionation. These diterpenoids inhibited superoxide anion production in the xanthine/xanthine oxidase system. Mitochondrial and ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Haraguchi H,Saito T,Okamura N,Yagi A

    更新日期:1995-08-01 00:00:00

  • Taxol biosynthesis: an update.

    abstract::The novel diterpenoid taxol (paclitaxel) is now well-established as a potent chemotherapeutic agent. Total synthesis of the drug is not commercially feasible and, in the foreseeable future, the supply of taxol and its synthetically useful progenitors must rely on biological methods of production. The first three steps...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Hezari M,Croteau R

    更新日期:1997-08-01 00:00:00

  • Inhibitory activity of soyasaponin II on virus replication in vitro.

    abstract::The antiviral activities of two saponins, soyasaponin I and II, isolated from soybean (Glycine max Merrill) were studied in vitro against herpes simplex virus type 1 (HSV-1). Soyasaponin II was more potent than soyasaponin I as shown by reduction of HSV-1 production. Soyasaponin II was also found to inhibit the replic...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Hayashi K,Hayashi H,Hiraoka N,Ikeshiro Y

    更新日期:1997-04-01 00:00:00

  • Old and new natural products as the source of modern antithrombotic drugs.

    abstract::Natural compounds have been the first historical source of antithrombotic compounds (heparin, vitamin K antagonists, streptokinase, urokinase); molecules extracted from plants or animals still provide some of the most original and promising approaches for the discovery of new drugs in this class. In this review, we wi...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Beretz A,Cazenave JP

    更新日期:1991-10-01 00:00:00

  • Two new C-benzylated dihydrochalcone derivatives from the leaves of Melodorum siamensis.

    abstract::Two new C-benzylated dihydrochalcone derivatives, 4,2',4'-trihydroxy-6'-methoxy-3'(2''-hydroxybenzyl)dihydrochalcone (1) and 2',4'-dihydroxy-4,6'-dimethoxy-3'(2''-hydroxybenzyl)dihydrochalcone (2), along with six known flavonoid derivatives (3-8), a known dihydrochalcone dimer (9), three known aromatic esters (10-12),...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Prawat U,Chairerk O,Phupornprasert U,Salae AW,Tuntiwachwuttikul P

    更新日期:2013-01-01 00:00:00

  • The structure and the stereochemistry of atractyliretin.

    abstract::The nor-kaurane diterpene Atractyliretin was obtained by acid hydrolysis of Atractyloside, a toxic substance isolated from ATRACTYLIS GUMMIFERA L (Compositae). On the basis of spectral (IR, (1)H-NMR, (13)C-NMR and MS) analysis and chemical degradation its structure and stereochemistry was identified as 4. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Camarda L,Ceraulo L,Ferrugia M,Pascual C,Sprio V

    更新日期:1986-10-01 00:00:00

  • Extracellular polysaccharides produced by suspension-cultured cells from Digitalis lanata.

    abstract::Extracellular polysaccharides (ECP) were isolated in yields of up to 4 mg/ml from the culture media of suspension-cultured cells from Digitalis lanata Ehrh. ECP content was increasing continuously over the first ten days of cultivation and then stayed constant until day 20. ECP were fractionated by ion-exchange chroma...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Hensel A,Schmidgall J,Kreis W

    更新日期:1997-10-01 00:00:00

  • Identification of New Diterpenes as Putative Marker Compounds Distinguishing Agnus Castus Fruit (Chaste Tree) from Shrub Chaste Tree Fruit (Viticis Fructus).

    abstract::Agnus Castus Fruit is defined in the European Pharmacopoeia as the dried ripe fruit of Vitex agnus-castus. In Europe it is used as a medicine targeting premenstrual syndrome and climacteric disorder. In Japan, Agnus Castus Fruit is becoming popular as a raw material for over-the-counter drugs and health food products,...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Oshima N,Masada S,Suzuki R,Yagi K,Matsufuji H,Suenaga E,Takahashi Y,Yahagi T,Watanabe M,Yahara S,Iida O,Kawahara N,Maruyama T,Goda Y,Hakamatsuka T

    更新日期:2016-01-01 00:00:00

  • Hepatoprotective flavonol glycosides from the aerial parts of Rodgersia podophylla.

    abstract::A new acylated flavonoid, quercetin 3- O-alpha- L-(5"- O-acetyl)-arabinofuranoside ( 1), along with six known flavonoids ( 2 - 7) were isolated from the aerial parts of Rodgersia podophylla. The new flavonoid 1 exhibited 50.1 % hepatoprotective activity at a concentration of 100 microM, and the three known compounds 3...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chin YW,Lim SW,Kim YC,Choi SZ,Lee KR,Kim J

    更新日期:2004-06-01 00:00:00

  • Possible active components of tan-shen (Salvia miltiorrhiza) for protection of the myocardium against ischemia-induced derangements.

    abstract::Extract of Tan-Shen (Salvia miltiorrhiza, Labiatae), a Chinese traditional crude drug, was reported to show beneficial activity for heart disease. Chemical examination on the extract was performed on the basis of screening for protective action on the ischemic myocardium. Isolated hearts were subjected to hypoxic perf...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yagi A,Fujimoto K,Tanonaka K,Hirai K,Takeo S

    更新日期:1989-02-01 00:00:00