Marine natural products research: current directions and future potential.

Abstract:

:Natural products research is increasingly turning to marine animals, plants, and microbes as source organisms. Several marine natural products are currently in preclinical and clinical evaluation, others show promising biological activities in in vitro and in vivo assays. Investigations of biological and chemical ecological phenomena in the marine world will contribute to a better understanding of marine habitats, and also provide a more founded basis regarding the search for pharmaceutically useful marine natural products.

journal_name

Planta Med

journal_title

Planta medica

authors

König GM,Wright AD

doi

10.1055/s-2006-957861

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

193-211

issue

3

eissn

0032-0943

issn

1439-0221

journal_volume

62

pub_type

杂志文章,评审
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    doi:10.1055/s-2005-871253

    authors: Melzig MF,Henke K

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  • Clonal propagation of Isoplexis canariensis.

    abstract::Isoplexis is a plant genus closely related to Digitalis. Members of this genus contain cardenolides considered more "primitive" than those present in Digitalis. Isoplexis plants, tissue cultures, and isolated cardenolides may thus be used to elucidate the biosynthesis of cardenolides in the Scrophulariaceae. Therefore...

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    doi:10.1055/s-2006-957937

    authors: Schaller F,Kreis W

    更新日期:1996-10-01 00:00:00

  • Cytotoxicity, apoptosis and DNA damage induced by Alpinia galanga rhizome extract.

    abstract::Alpinia galanga, or galangal, has been a popular condiment used in Thai and Asian cuisine for many years. However, relatively little is known of the potential beneficial or adverse health effects of this spice. This study was conducted to analyze the capacity of galangal extract to induce cytotoxicity and DNA damage i...

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    doi:10.1055/s-2007-981542

    authors: Muangnoi P,Lu M,Lee J,Thepouyporn A,Mirzayans R,Le XC,Weinfeld M,Changbumrung S

    更新日期:2007-07-01 00:00:00

  • Analgesic and behavioural effects of Morinda citrifolia.

    abstract::The traditional therapeutic indications for the use of Morinda citrifolia L. (Rubiaceae) have been investigated. The lyophilised aqueous extract of roots of M. citrifolia was evaluated for analgesic and behavioural effects in mice. The extract did not exhibit any toxic effects but did show a significant, dose-related,...

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    doi:10.1055/s-2006-961004

    authors: Younos C,Rolland A,Fleurentin J,Lanhers MC,Misslin R,Mortier F

    更新日期:1990-10-01 00:00:00

  • Thalivarmine and Thalsivasine: Two New Bisbenzylisoquinoline Alkaloids from Thalictrum minus var. minus.

    abstract::Thalivarmine and thalsivasine, together with the known bases thalmelatidine, thalicberine, O-methylthalicberine, thaliphylline, thalmethine, O-methylthalmethine and (-)- N-methylcanadine have been isolated from the above ground parts of THALICTRUM MINUS var. MINUS L. ...

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    doi:10.1055/s-2007-969547

    authors: Başer KH,Kinmer N

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  • New coumarins from Pterocaulon polystachyum.

    abstract::Aerial parts of Pterocaulon polystachyum from Chaco province, Argentina, afforded the known coumarins ayapin, isoscopoletin, prenyletin, prenyletin methyl ether, virgatenol, obtusinin, 5-methoxy-6,7-methylenedioxycoumarin, 5-(3,3-dimethylallyloxy)-6,7-methylenedioxycoumarin, 5-(2',3'-dihydroxy-3-methylbutanoxy)-6,7-me...

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    pub_type: 信件

    doi:10.1055/s-2001-17365

    authors: Vera N,Bardón A,Catalán CA,Gedris TE,Herz W

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  • Evaluation of cytotoxic activity of Schisandra chinensis lignans.

    abstract::Using exhaustive chromatographic separation we have isolated (-)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-γ-schisandrin, (-)-gomisin J, (+)-gomisin A, (-)-gomisin N, (-)-tigloyl-...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1249861

    authors: Smejkal K,Slapetová T,Krmenčík P,Babula P,Dall'Acqua S,Innocenti G,Vančo J,Casarin E,Carrara M,Kalvarová K,Dvorská M,Slanina J,Kramářová E,Julínek O,Urbanová M

    更新日期:2010-10-01 00:00:00

  • Pyrrolizidine alkaloids from Eupatorium portoricense.

    abstract::Three pyrrolizidine alkaloids were isolated from Eupatorium portoricense and their structures elucidated by spectroscopic methods as (-)-viridifloryl-supinidine (amabiline), (-)-viridifloryl-heliotridine (echinatine), and C12- O-acetyl-(-)-viridifloryl-heliotridine (O(12)-acetylechinatine). ...

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    pub_type: 信件

    doi:10.1055/s-2006-958112

    authors: Wiedenfeld H,Guerrero R,Roeder E

    更新日期:1995-08-01 00:00:00

  • Determination of Acid and Neutral Cannabinoids in Extracts of Different Strains of Cannabis sativa Using GC-FID.

    abstract::Cannabis (Cannabis sativa L.) is an annual herbaceous plant that belongs to the family Cannabaceae. Trans-Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two major phytocannabinoids accounting for over 40% of the cannabis plant extracts, depending on the variety. At the University of Mississippi, differ...

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    pub_type: 杂志文章

    doi:10.1055/s-0043-124088

    authors: Ibrahim EA,Gul W,Gul SW,Stamper BJ,Hadad GM,Abdel Salam RA,Ibrahim AK,Ahmed SA,Chandra S,Lata H,Radwan MM,ElSohly MA

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  • Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from ginkgo biloba leaves.

    abstract::Ginkgetin, a biflavone isolated from Ginkgo biloba leaves, was previously reported as an inhibitor of group II phospholipase A2. In this study, ginkgetin was evaluated for in vivo antiarthritic and analgesic activities. Ginkgetin (10-20 mg/kg/day) strongly reduced arthritic inflammation in an animal model of rat adjuv...

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  • Antifungal chromans inhibiting the mitochondrial respiratory chain of pea seeds and new xanthones from Calophyllum caledonicum.

    abstract::Two new xanthones, caledonixanthone M 1 and caloxanthone L 2, and one new acid, caledonic acid 6 were isolated from the hexane-soluble extract of the stem bark of Calophyllum caledonicum. In the course of this phytochemical study, seven other known compounds - calothwaitesixanthone, calozeyloxanthone, allanxanthone, i...

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    pub_type: 杂志文章

    doi:10.1055/s-2003-818004

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  • New camptothecin and ellagic acid analogues from the root bark of Camptotheca acuminata.

    abstract::As part of a study on chemical constituents of Camptotheca species, one new natural camptothecin analogue (2), two new alkaloids (3, 4), one new ellagic acid analogue (5), and 19 known compounds (1, 6-23) have been isolated from the root bark, stem bark, fruits, and leaves of Camptotheca acuminata Decaisne. The struct...

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  • Ilex aquifolium: protection against enzymatic and non-enzymatic lipid peroxidation.

    abstract::The ethanolic extract of Ilex aquifolium L. (Aquifoliaceae) concentration-dependently inhibited leukotriene B4 biosynthesis in isolated bovine PMNL with an IC50 value of about 60 micrograms/ml, whereas the effect on epidermal 12(S)-HETE biosynthesis was much less pronounced. The extract also inhibited the non-enzymati...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957509

    authors: Müller K,Ziereis K,Paper DH

    更新日期:1998-08-01 00:00:00

  • Intestinal immune system modulating polysaccharides from rhizomes of Atractylodes lancea.

    abstract::Hot water extract (ALR-0) of rhizomes of Atractylodes lanceo DC. was fractionated into MeOH-soluble fraction (ALR-1), supernatant fraction of EtOH precipitation (ALR-3 + 4), and crude polysaccharide fraction (ALR-5). Among these fractions, only ALR-5 showed potent stimulating activity for proliferation of bone marrow ...

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    pub_type: 杂志文章

    doi:10.1055/s-2006-957564

    authors: Yu KW,Kiyohara H,Matsumoto T,Yang HC,Yamada H

    更新日期:1998-12-01 00:00:00

  • Inhibition of human dendritic cell activation by hydroethanolic but not lipophilic extracts of turmeric (Curcuma longa).

    abstract::Turmeric has been extensively utilized in Indian and Chinese medicine for its immune-modulatory properties. Dendritic cells (DCs) are antigen-presenting cells specialized to initiate and regulate immunity. The ability of DCs to initiate immunity is linked to their activation status. The effects of turmeric on human DC...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0028-1088367

    authors: Krasovsky J,Chang DH,Deng G,Yeung S,Lee M,Leung PC,Cunningham-Rundles S,Cassileth B,Dhodapkar MV

    更新日期:2009-03-01 00:00:00

  • Guaianolides from Lactuca saligna.

    abstract::The phytochemical investigation of the aerial parts of LACTUCA SALIGNA L. revealed the presence of lactucin, lactucopicrin, and a new guaianolide named 11beta,13-dihydrolactucopicrin. The structural configuration was established through spectral data. ...

    journal_title:Planta medica

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    doi:10.1055/s-2006-960064

    authors: Khalil AT,El-Fattah HA,Mansour ES

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  • Inhibition of activator protein 1 activity by berberine in human hepatoma cells.

    abstract::Activator protein 1 (AP-1) is a transcription factor which plays a critical role in inflammation and carcinogenesis. The present study was conducted to investigate the effect of berberine, an isoquinoline alkaloid present in plants of the genera Berberis and Coptis, on the activity of AP-1 using a reporter gene assay ...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-960795

    authors: Fukuda K,Hibiya Y,Mutoh M,Koshiji M,Akao S,Fujiwara H

    更新日期:1999-05-01 00:00:00

  • Galanthindole: a new indole alkaloid from Galanthus plicatus ssp. byzantinus.

    abstract::A new indole alkaloid, galanthindole, was isolated from Galanthus plicatus ssp. byzantinus (Amaryllidaceae), a plant native to northwestern Turkey. Incorporating a non-fused indole ring, galanthindole may represent the prototype of a new subgroup of the Amaryllidaceae alkaloids. Two other bases, (+)-11-hydroxyvittatin...

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    doi:10.1055/s-2003-43206

    authors: Unver N,Kaya GI,Werner C,Verpoorte R,Gözler B

    更新日期:2003-09-01 00:00:00

  • Reversal caused by n-butylidenephthalide from the deficits of inhibitory avoidance performance in rats.

    abstract::The present study was designed to investigate the mechanism of action of n-butylidenephthalide on the deficits of inhibitory avoidance performance induced by drugs in rats with piracetam as a positive control. n-Butylidenephthalide attenuated the scopolamine-induced and mecamylamine-induced acquisition impairment, and...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2001-10631

    authors: Hsieh MT,Wu CR,Lin LW,Hsieh CC,Tsai CH

    更新日期:2001-02-01 00:00:00

  • Recent development of antitumor agents from Chinese herbal medicines. Part II. High molecular compounds(3).

    abstract::High molecular compounds from Chinese herbal medicines, including ribosome-inactivating proteins and polysaccharides from both fungi and high plants have been tested for the treatment of malignant diseases. Polysaccharides possessing immunostimulating activities can be used as adjuvants in tumor treatment. The fungi c...

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    pub_type: 杂志文章,评审

    doi:10.1055/s-2003-38494

    authors: Tang W,Hemm I,Bertram B

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  • Alkaloids from Papaver triniifolium of Turkish Origin1.

    abstract::The major alkaloids of PAPAVER TRINIIFOLIUM collected in two different parts of Anatolia have proved to be of the aporphine, morphinane and rhoeadine types. The two collections possessed different major alkaloids and the existence of chemical strains is indicated. In addition to the aporphine-(floripavidine), the morp...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969808

    authors: Sariyar G

    更新日期:1983-09-01 00:00:00

  • Encelin: a fungal growth inhibitor.

    abstract::A known sesquiterpene lactone, encelin, isolated from the Mexican species Montanoa speciosa (Compositae), was assayed for biocidal activity on fungal cells of Mucor rouxii. The results indicate that encelin has a determining action on growth and the morphogenetic process of fungal cells. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-958046

    authors: Sabanero M,Quijano L,Rios T,Trejo R

    更新日期:1995-04-01 00:00:00

  • Antinociception caused by the extract of Hedyosmum brasiliense and its active principle, the sesquiterpene lactone 13-hydroxy-8,9-dehydroshizukanolide.

    abstract::The hydroalcoholic extract (HE) obtained from stems and leaves of Hedyosmum brasiliense, given i.p., produced significant inhibition of acetic acid-induced abdominal constriction in mice, with a mean ID50 of 12.7 mg/kg. This effect installed rapidly (0.5 h) and lasted for up to 2 h. Given orally up to 1000 mg/kg, the ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-1999-14007

    authors: Trentin AP,Santos AR,Guedes A,Pizzolatti MG,Yunes RA,Calixto JB

    更新日期:1999-08-01 00:00:00

  • Chemical Varieties of Essential Oils from Elsholtzia polystachya from Two Different Locations in India1.

    abstract::Capillary GC, GC-MS, IR, GC-IR, (1)H- and (13)C-NMR studies of the essential oil from the leaves and cones of ELSHOLTZIA POLYSTACHYA collected from two different locations in India revealed that one oil contained 1,8-cineol (37.3%), the other one perillene (61.2%) as the main constituent. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-961490

    authors: Mathela CS,Melkani AB,Bisht JC,Pant AK,Bestmann HJ,Erler J,Kobold U,Rauscher J,Vostrowsky O

    更新日期:1992-08-01 00:00:00

  • Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection.

    abstract::Many compounds of plant origin have been identified that inhibit different stages in the replication cycle of human immunodeficiency virus (HIV): 1) virus adsorption: chromone alkaloids (schumannificine), isoquinoline alkaloids (michellamines), sulphated polysaccharides and polyphenolics, flavonoids, coumarins (glycoc...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-2006-957384

    authors: Vlietinck AJ,De Bruyne T,Apers S,Pieters LA

    更新日期:1998-03-01 00:00:00

  • Quantitative analysis of strychnine and Brucine in Strychnos nux-vomica using 1H-NMR.

    abstract::A quantitative analysis using (1)H-NMR (Q-NMR) has been developed for the determination of strychnine and brucine in Strychnos nux-vomica seeds and stems. The advantages of the method are that no reference alkaloids are needed for calibration curves, the quantification could be directly realized on a crude extract, st...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2003-818014

    authors: Frédérich M,Choi YH,Verpoorte R

    更新日期:2003-12-01 00:00:00

  • The selective antianginal effect without changing blood pressure of butylidenephthalide in conscious rats.

    abstract::Synthetic butylidenephthalide (Bdph), 60 mg/kg per os (p.o.) given 3 h prior to injection of pituitrin (4 U/kg, i.v.), significantly prevented T-wave lowering on lead II electrocardiograph in unanesthetized rats. The effective dose, 60 mg/kg, was about 1/56th of the median lethal dose (LD50, p.o.) in rats. However, Bd...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957415

    authors: Ko WC,Sheu JR,Tzeng SH,Chen CM

    更新日期:1998-04-01 00:00:00

  • Growth of cultured human bronchiogenic epithelioid CCD-14 Br cells and dermal fibroblasts, NB1 RGB treated with ginseng tetrapeptide and its isomer.

    abstract::The configurations of the component amino acids in ginseng tetrapeptide 1 isolated from Panax ginseng were determined by HPLC with an optical resolution column and the structure of 1 was established to be H-L-Val-gamma-D-Glu-D-Arg- Gly-OH. Synthesis of the ginseng tetrapeptide, 1, and of the configuration and conjugat...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957830

    authors: Yagi A,Ishizu T,Okamura N,Noguchi S,Itoh H

    更新日期:1996-04-01 00:00:00

  • Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.

    abstract::The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavai...

    journal_title:Planta medica

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-2006-957450

    authors: Shoba G,Joy D,Joseph T,Majeed M,Rajendran R,Srinivas PS

    更新日期:1998-05-01 00:00:00

  • Antioxidant effects of 1,5-anhydro-D-fructose, a new natural sugar, in vitro.

    abstract::The antioxidant effects of 1,5-anhydro-D-fructose (1,5-AF), a unique anhydrohexulose, were studied in 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution, in human cells along with lipid peroxidation of low-density lipoprotein (LDL). We have confirmed that 1,5-AF scavenges DPPH radicals directly in solution and inhibits the...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2002-20050

    authors: Yamaji K,Sarker KP,Maruyama I,Hizukuri S

    更新日期:2002-01-01 00:00:00