Abstract:
:A novel trinorsesquiterpene (1), three new (2-4), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibition of LPS-induced nitric oxide production in RAW264.7 macrophages, and the results indicated that compounds 9, 12, and 13 moderately inhibited nitric oxide production with IC₅₀ values of 7.39 ± 0.36, 6.35 ± 0.26, and 5.39 ± 0.18 µM, respectively.
journal_name
Planta Medjournal_title
Planta medicaauthors
Zhang SD,Qin JJ,Jin HZ,Yin YH,Li HL,Yang XW,Li X,Shan L,Zhang WDdoi
10.1055/s-0031-1280294subject
Has Abstractpub_date
2012-01-01 00:00:00pages
166-71issue
2eissn
0032-0943issn
1439-0221journal_volume
78pub_type
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