Sesquiterpenoids from Inula racemosa Hook. f. inhibit nitric oxide production.

Abstract:

:A novel trinorsesquiterpene (1), three new (2-4), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibition of LPS-induced nitric oxide production in RAW264.7 macrophages, and the results indicated that compounds 9, 12, and 13 moderately inhibited nitric oxide production with IC₅₀ values of 7.39 ± 0.36, 6.35 ± 0.26, and 5.39 ± 0.18 µM, respectively.

journal_name

Planta Med

journal_title

Planta medica

authors

Zhang SD,Qin JJ,Jin HZ,Yin YH,Li HL,Yang XW,Li X,Shan L,Zhang WD

doi

10.1055/s-0031-1280294

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

166-71

issue

2

eissn

0032-0943

issn

1439-0221

journal_volume

78

pub_type

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