Abstract:
:Bioassay-guided fractionation of the hexanic root bark extract of Casearia sylvestris var. lingua led to the isolation of a new clerodane diterpene, whose structure was elucidated as rel-(2 S,5 R,6 R,8 S,9 S,10 R,18 S,19 R)-19-acetoxy-18,19-epoxy-6-hydroxy-18-butanoyloxy-2-(2-methylbutanoyloxy)cleroda-3,13(16), 14-triene by spectroscopic means, including 1D and 2D NMR analyses. This compound showed pronounced activity on Trypanosoma cruzi, the casual agent of Chagas' disease, with minimal inhibitory concentration (MIC) at 0.59 microg/mL.
journal_name
Planta Medjournal_title
Planta medicaauthors
Espindola LS,Vasconcelos Júnior JR,de Mesquita ML,Marquié P,de Paula JE,Mambu L,Santana JMdoi
10.1055/s-2004-832655subject
Has Abstractpub_date
2004-11-01 00:00:00pages
1093-5issue
11eissn
0032-0943issn
1439-0221journal_volume
70pub_type
杂志文章相关文献
PLANTA MEDICA文献大全abstract::The flowers of ARNICA MOLLIS afforded, in addition to baileyin ( 1A), baileyin acetate ( 1B), xanthalongin ( 3), and 2-deacetoxy-11alpha,13-dihydroxanthuminol ( 6), the new 1,5- CIS-guaianolides arnimollin acetate ( 2A) and arnimollin tiglinate ( 2A) and the new xanthanolides 11beta3,13-dihydroxanthalongin ( 4) and 11...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960898
更新日期:1990-02-01 00:00:00
abstract::Natural compounds have been the first historical source of antithrombotic compounds (heparin, vitamin K antagonists, streptokinase, urokinase); molecules extracted from plants or animals still provide some of the most original and promising approaches for the discovery of new drugs in this class. In this review, we wi...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:
更新日期:1991-10-01 00:00:00
abstract::Sigmoidin A (SGN) is a prenylated flavanone derivative of eriodictyol (ERD) with reported moderate antioxidant, antimicrobial and anti-inflammatory activity. Since ERD and other structurally similar antioxidant phenolic compounds have been shown to induce prooxidative macromolecular damage and cytotoxicity in cancer c...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1240604
更新日期:2010-04-01 00:00:00
abstract::In this work we studied the effect of alpha-asarone, a hypolipidemic active principle of Guatteria gaumeri Greenman, on hepatic lipid metabolism using adult rat hepatocytes cultured on a feeder layer of 3T3 cells. These cultures synthesize and secrete for at least two weeks various lipids from [14C]-acetic and [14C]-o...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-959625
更新日期:1993-04-01 00:00:00
abstract::The investigation of the roots and aerial parts of EUPATORIUM CANNABIUM afforded, in addition to the sesquiterpene lactones eupatolide, eupatoriopicrin, and eucannabinolide isolated previously, eight further lactones, three of which are new. Furthermore, in addition to known compounds, a new clerodane derivative and t...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-962665
更新日期:1987-04-01 00:00:00
abstract::Hot water extract (ALR-0) of rhizomes of Atractylodes lanceo DC. was fractionated into MeOH-soluble fraction (ALR-1), supernatant fraction of EtOH precipitation (ALR-3 + 4), and crude polysaccharide fraction (ALR-5). Among these fractions, only ALR-5 showed potent stimulating activity for proliferation of bone marrow ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957564
更新日期:1998-12-01 00:00:00
abstract::The neuroprotective effects of spiramine T, an atisine-type diterpenoid alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceaee), on cerebral ischemia-reperfusion injury produced by 10-min bilateral occlusion of the common carotid arteries followed by 5-day reperfusion in gerbils were...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2001-11510
更新日期:2001-03-01 00:00:00
abstract::Two new lignans, (-)-aptosimon ( 1) and (-)-diasesamin-di-gamma-lactone ( 2), together with twenty-two known compounds, have been isolated from the stems and roots of Wikstroemia lanceolata. The structures of the new compounds were determined through spectral analyses. The proton and carbon assignments of the known se...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2004-815540
更新日期:2004-03-01 00:00:00
abstract::In an attempt to induce positive effects on the acclimatization of in vitro propagated Echinacea pallida, four arbuscular mycorrhizal (AM) fungi, Glomus mosseae, Gigaspora ramisporophora, Scutellospora fulgida and Entrophospora colombiana were selected to aid the soil adaptation process. Fungal inocula affected the su...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2003-41124
更新日期:2003-07-01 00:00:00
abstract::The present study explores the potential of nanoemulsion, a lipid drug delivery system, to improve solubility and oral absorption of Silybum marianum extract. The optimized formulation contained 40 mg/mL of commercial extract (4 % w/w) and it was composed of 2.5 g labrasol (20 %) as the oil phase, 1.5 g cremophor EL a...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0043-110052
更新日期:2017-10-01 00:00:00
abstract::The concentrations of taxol and related compounds in the bark and needles of Taxus cuspidata grown on Mt. Jiri, Mt. Sobaek, and Cheju Island, and T. cuspidata var. latifolia on Ullung Island in Korea were determined by high performance liquid chromatography (HPLC). The taxane content significantly varied with the loca...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-958069
更新日期:1995-06-01 00:00:00
abstract::Natural products research is increasingly turning to marine animals, plants, and microbes as source organisms. Several marine natural products are currently in preclinical and clinical evaluation, others show promising biological activities in in vitro and in vivo assays. Investigations of biological and chemical ecol...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-2006-957861
更新日期:1996-06-01 00:00:00
abstract::The isoflavonoids found in soy have attracted great interest as dietary phytoestrogens that might be effective for postmenopausal hormone replacement therapy. Special attention has been devoted to the hormonal effects of various isoflavonoids, like genistein (GEN) and daidzein's (DAID) potent metabolite, equol (EQ). H...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1186136
更新日期:2010-02-01 00:00:00
abstract::This study evaluated the susceptibility of oral pathogenic microorganisms Candida albicans, Streptococcus mutans, Staphylococcus aureus, and Aggregatibacter actinomycetemcomitans to Brazilian medicinal plant extracts of Schinus terebinthifolius (aroeira), Croton campestris (velame), Lafoensia pacari (pacari), Centauri...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1250354
更新日期:2011-03-01 00:00:00
abstract::Bioassay-guided isolation of two new compounds, 3,4-methylenedioxy-3'-O-methyl-4'-O-glucoside ellagic acid (1) and the pteleoellagic acid derivative (2), from the stem bark of Pteleopsis hylodendron is reported along with 3,4-methylenedioxy-3'-O-methyl ellagic acid (3), 3,3'-di-O-methyl ellagic acid (4) and 3,3',4'-tr...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2001-14306
更新日期:2001-06-01 00:00:00
abstract::The crude ethanol extract from the leaves of Dendropanax arboreus (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-G2, A-431, H-4IIE, and L-1210 tumor cell lines, but is not toxic against normal hepatocytes. The active component has been isolated by activity-directed separation and ide...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-958139
更新日期:1995-10-01 00:00:00
abstract::Two new C(18) dibenzocyclooctadiene lignans named heteroclitalignans A and B (1 and 3), one new C(19) homolignan named heteroclitalignan C(4) and one new natural product named heteroclitalignan D(2), together with the four known lignans kadsurarin (5), kadsulignan E (6), d-epigalbacin, and meso-dihydroguaiaretic acid ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-916213
更新日期:2006-02-01 00:00:00
abstract::Six diarylheptanoids were isolated from the rhizome of Alpinia officinarum (Zingiberaceae) as inhibitors of nitric oxide (NO) production in the lipopolysaccharide-activated macrophage cell line RAW 264.7. A double bond at C-4 of the linker between two aromatic rings was found to be essential for activity. Furthermore,...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-873176
更新日期:2006-01-01 00:00:00
abstract::A microdilution technique was developed for the assessment of in vitro cytotoxicity against KB cells derived from a human epidermoid carcinoma of the nasopharynx. The test was used to determine the cytotoxicity of a series of quassinoids, isolated from Brucea javanica, and which have previously been shown to demonstra...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960020
更新日期:1991-02-01 00:00:00
abstract::The traditional analgesic and antipyretic Ethiopian drug "Dingetegna" is made of dried root material of Taverniera abyssinica A. Rich (Leguminosae). In a screening for nematicidal natural products, "Dingetegna" extracts showed strong nematicidal activities towards C. elegans. In the following, medicarpin and 4-hydroxy...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-959569
更新日期:1994-12-01 00:00:00
abstract::Five compounds representative of major structural classes of lichen polyketides, VIZ. (+)-usnic (1), salazinic (2), vulpinic (3), gyrophoric (4), and evernic acids (5), were investigated for their ability to affect cell proliferation or wound healing, two functional targets of relevance for research on cancer or tissu...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1185329
更新日期:2009-05-01 00:00:00
abstract::The known alkaloids (+/-)-stylopine, (+/-)-sinactine, protopine, (+)-bulbocapnine, (-)-domesticine, (+)-corydine and (+)-isoboldine were found in the mixture of alkaloids from Corydalis marschalliana (Papaveraceae), growing in Bulgaria. The alkaloids dehydronantenine, (+)-nantenine and oxonantenine were isolated for t...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971718
更新日期:1981-03-01 00:00:00
abstract::Soybean saponin is one of several soybean glycosides. Recently, new soybean saponins which possess the DDMP (2,5-dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one) moiety have been detected. Soyasaponin beta g of these new soybean saponins was shown to inhibit hydrogen peroxide damage to mouse fibroblast cells. Not only t...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957871
更新日期:1996-06-01 00:00:00
abstract::One new triterpene, kudinchalactone A (1), and four new triterpenoid saponins, ilekudinchosides A-D (2- 5), were isolated from the leaves of Ilex kudincha C. J. Tseng along with eight known triterpenoids. These new compounds were elucidated by spectroscopic methods including 1D and 2D NMR, HR-TOF-MS, and CD spectra. C...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1271164
更新日期:2011-11-01 00:00:00
abstract::The steam distilled oils both from flowers and leaves, as well as from total aerial parts of CHRYSANTHEMUM INDICUM L. (small-flowered form), were obtained and analyzed by GC and GC/MS. Their main components are borneol, chrysanthenone and bornyl acetate. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969858
更新日期:1983-12-01 00:00:00
abstract::In this study the skin permeation and the topical anti-inflammatory properties of ginger extracts were investigated. A commercial ginger dry extract (DE) and a gingerols-enriched dry extract (EDE) were evaluated for their in vivo topical anti-inflammatory activity by inhibition of Croton oil-induced ear oedema in mice...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-993741
更新日期:2007-12-01 00:00:00
abstract::The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model,...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-1999-13998
更新日期:1999-05-01 00:00:00
abstract::Ganoderan B increased the plasma insulin level in normal and glucose-loaded mice but elicited no effect on insulin binding to isolated adipocytes. Administration of ganoderan B elicited significant increases of the activities of hepatic glucokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase, decreased ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-962057
更新日期:1989-10-01 00:00:00
abstract::Cordatolide A and B were re-isolated from Calophyllum cordato-oblongum, an endemic species of Sri Lanka, and found to inhibit HIV-1 reverse transcriptase with IC50 values of 12.3 and 19.0 microM, respectively. ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-957483
更新日期:1998-06-01 00:00:00
abstract::Infections caused by HSV-2 are a public health concern worldwide, and there is still a great demand for the discovery of novel anti-herpes virus agents effective against strains resistant to current antiviral agents. In this context, medicinal plants represent an alternative source of active compounds for developing e...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-1087-8303
更新日期:2020-03-01 00:00:00