Abstract:
:A new resveratrol dimer, (+)-vitisinol E (1) which demonstrated inhibitory activity on BACE-1 (beta-site APP-cleaving enzyme 1) in vitro, was isolated from the stembark extract of Vitis vinifera (Vitaceae) together with four known resveratrol oligomers, (+)-epsilon-viniferin (2), (+)-ampelopsin A (3), (+)-vitisin A (4) and (-)-vitisin B (5). The chemical structure of 1 was established by MR spectroscopic analyses, including HMBC. All isolated resveratrol derivatives (1-5) demonstrated significant inhibition on baculovirus-expressed BACE-1 in a dose-dependent manner, which was assessed with the FRET assay using Rh-EVNLDAEFK as a substrate in vitro.
journal_name
Planta Medjournal_title
Planta medicaauthors
Choi YH,Yoo MY,Choi CW,Cha MR,Yon GH,Kwon DY,Kim YS,Park WK,Ryu SYdoi
10.1055/s-0029-1185311subject
Has Abstractpub_date
2009-04-01 00:00:00pages
537-40issue
5eissn
0032-0943issn
1439-0221journal_volume
75pub_type
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