Abstract:
:Two new protopine-type alkaloids, argemexicaine A (1) and argemexicaine B (2), along with thirteen known alkaloids, were isolated from MeOH extracts of Formosan Argemone mexicana L. (Papaveraceae). Physical and spectral analyses, particularly IR and thermo-modulated 1D and 2D NMR, were used to determine the transannular conformations of the isolated protopine-type alkaloids. The known benzo[ c]phenanthridine (+/-)-6-acetonyldihydrochelerythrine (5) exhibited significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively.
journal_name
Planta Medjournal_title
Planta medicaauthors
Chang YC,Hsieh PW,Chang FR,Wu RR,Liaw CC,Lee KH,Wu YCdoi
10.1055/s-2003-37710subject
Has Abstractpub_date
2003-02-01 00:00:00pages
148-52issue
2eissn
0032-0943issn
1439-0221journal_volume
69pub_type
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