Possible active components of tan-shen (Salvia miltiorrhiza) for protection of the myocardium against ischemia-induced derangements.

Abstract:

:Extract of Tan-Shen (Salvia miltiorrhiza, Labiatae), a Chinese traditional crude drug, was reported to show beneficial activity for heart disease. Chemical examination on the extract was performed on the basis of screening for protective action on the ischemic myocardium. Isolated hearts were subjected to hypoxic perfusion for 20 min, followed by 45 min reoxygenation, and the recovery of cardiac contractile force and changes in UV absorbance of the perfusate were examined. Among the components isolated, tanshinone I, cryptotanshinone, and tanshinone VI elicited a significant enhanced recovery of the contractile force upon reoxygenation. This was associated with a decrease in the increase in UV absorbance of the perfusate, suggesting the preservation of ATP metabolites in the myocardium. This, in turn, may enhance the restoration of ATP upon oxygen-replenishment. The results suggest that tanshinone I, cryptotanshinone, and tanshinone VI can protect the myocardium against ischemia-induced derangements.

journal_name

Planta Med

journal_title

Planta medica

authors

Yagi A,Fujimoto K,Tanonaka K,Hirai K,Takeo S

doi

10.1055/s-2006-961824

subject

Has Abstract

pub_date

1989-02-01 00:00:00

pages

51-4

issue

1

eissn

0032-0943

issn

1439-0221

journal_volume

55

pub_type

杂志文章
  • Accumulation of hydrolyzable tannins by Aleurites fordii callus culture.

    abstract::A callus culture of Aleurites fordii Hemsley (Euphorbiaceae) producing five galloylglucoses and an ellagitannin, geraniin, was established. The production of pentagalloylglucose was remarkably enhanced under light irradiation compared with that in the dark. Cell growth and tannin production were also greatly affected ...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2002-36348

    authors: Taniguchi S,Uechi K,Kato R,Ito H,Hatano T,Yazaki K,Yoshida T

    更新日期:2002-12-01 00:00:00

  • Chemical and pharmacological investigation of the stem bark of Synadenium grantii.

    abstract::Based on the fact that Synadenium grantii is used in folk medicine for the treatment of peptic ulcers and inflammatory diseases, this work describes its chemical and pharmacological properties. Pharmacological investigation of the crude bark extract showed a high antioxidant activity over several scavenger systems, su...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0034-1368300

    authors: Munhoz AC,Minozzo BR,Cruz LS,Oliveira TL,Machado WM,Pereira AV,Fernandes D,Manente FA,Vellosa JC,Nepel A,Barison A,Beltrame FL

    更新日期:2014-04-01 00:00:00

  • Ilex aquifolium: protection against enzymatic and non-enzymatic lipid peroxidation.

    abstract::The ethanolic extract of Ilex aquifolium L. (Aquifoliaceae) concentration-dependently inhibited leukotriene B4 biosynthesis in isolated bovine PMNL with an IC50 value of about 60 micrograms/ml, whereas the effect on epidermal 12(S)-HETE biosynthesis was much less pronounced. The extract also inhibited the non-enzymati...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957509

    authors: Müller K,Ziereis K,Paper DH

    更新日期:1998-08-01 00:00:00

  • Cycloetherification of hydroxyoleanenes by N-bromosuccinimide.

    abstract::Treatment of 28-hydroxyolean-12-enes with N-bromosuccinimide (NBS) in acetonitrile at room temperature afforded 12 alpha-bromooleanan-13beta, 28-epoxides in high yield. This reaction resulted in the formation of olean-9 (11), 12-diene-18alpha, 29-epoxides from 29-hydroxy isomers but recovered only starting materials f...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969575

    authors: Woo WS,Kang SS,Jew SS

    更新日期:1985-12-01 00:00:00

  • Determination of Final Steps in Biosyntheses of Essential Oil Components in Perilla frutescens.

    abstract::Biosynthetic pathways of the essential oil components in PERILLA FRUTESCENS were examined by tracer experiments using [ (14)C]-labeled sucrose on two chemotypes: perillaketone (PK) and phenylpropanoid (PP-EM) types. The results of the experiments indicated that perillaketone is not converted from isoegomaketone but is...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-961996

    authors: Nishizawa A,Honda G,Tabata M

    更新日期:1989-06-01 00:00:00

  • Assay of volatile oil-cyclodextrin complexes by pyrolyzis gas-chromatography.

    abstract::A pyrolytic gaschromatographic process was developed for the routine assay of both cyclodextrin inclusion complexes, and for the differentiation of the mechanical mixture of the same oil with beta-cyclodextrin. The method is a direct assay of low material demand. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-971636

    authors: Pobozsny K,Kernóczi L,Tétényi P,Héthelyi I,Szejtli J

    更新日期:1981-07-01 00:00:00

  • Inhibitory activities of lichen-derived compounds against methicillin- and multidrug-resistant Staphylococcus aureus.

    abstract::The inhibitory effects of selected phenolic lichen substances were tested against a panel of methicillin- and multidrug-resistant Staphylococcus aureus. Depsidones with long alkyl chains on both of the aromatic rings were consistently active against the strains tested, comparable to or better than the level of clinica...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957070

    authors: Kokubun T,Shiu WK,Gibbons S

    更新日期:2007-02-01 00:00:00

  • Aromatase inhibitory activities of standishinal and the diterpenoids from the bark of Thuja standishii.

    abstract::The absolute stereostructure of a novel skeletal diterpene, standishinal (1), from the bark of Thuja standishii was confirmed by X-ray crystallographic analyses of 1 and its p-bromobenzoate derivative. Aromatase inhibitory activities of standishinal, eight known diterpenes, totarol, 12-methoxyabieta-8,11,13-trien-11-o...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2002-33787

    authors: Minami T,Iwamoto M,Ohtsu H,Ohishi H,Tanaka R,Yoshitake A

    更新日期:2002-08-01 00:00:00

  • A Simple and Sensitive LC-MS/MS Method for Determination of Four Major Active Diterpenoids from Andrographis paniculata in Human Plasma and Its Application to a Pilot Study.

    abstract::Andrographis paniculata contains four major active diterpenoids, including andrographolide (1), 14-deoxy-11, 12-didehydroandrographolide (2), neoandrographolide (3), and 14-deoxyandrographolide (4), which exhibit differences in types and/or degrees of their pharmacological activity. Previous pharmacokinetic studies in...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0035-1558115

    authors: Pholphana N,Panomvana D,Rangkadilok N,Suriyo T,Ungtrakul T,Pongpun W,Thaeopattha S,Satayavivad J

    更新日期:2016-01-01 00:00:00

  • Influence of acetonylgeraniin, a hydrolyzable tannin from Euphoria longana, on orthostatic hypotension in a rat model.

    abstract::Acetonylgeraniin, an active principle isolated from the seeds of Euphoria longana Lam. (Sapindaceae), reversed the fall in arterial blood pressure in conscious hypertensive rats (SHRs) with orthostatic hypotension induced by injection of hexamethonium into animals subjected to 90 degrees head-up tilts for 60 seconds. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-959487

    authors: Hsu FL,Lu FH,Cheng JT

    更新日期:1994-08-01 00:00:00

  • Chemical constituents from the stem bark of Trewia nudiflora L. and their antioxidant activities.

    abstract::Three new compounds, namely, (+)-dihydrodehydrodiconiferyl alcohol 4- O- beta-(6''- O-galloyl)-glucopyranoside ( 1), 4,4'- O-dimethylellagic acid 3-(2''- O-acetyl)- alpha-rhamnopyranoside ( 2), and ethyl O- beta-(6'-galloyl)-glucopyranoside ( 3), together with eleven known ones, were isolated from the stem bark of Tre...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034361

    authors: Kang QJ,Yang XW,Wu SH,Ma YL,Li L,Shen YM

    更新日期:2008-03-01 00:00:00

  • Antitumor activity of PEGylated nanoliposomes containing crocin in mice bearing C26 colon carcinoma.

    abstract::Crocin is a pharmacologically active component of Crocus sativus. It is an unusual water-soluble carotenoid responsible for the red color of saffron. In various studies, the anticancer effect of saffron and its constituents has been established. Polyethylene glycolated nanoliposomes with a size range up to 200 nm are ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1328363

    authors: Rastgoo M,Hosseinzadeh H,Alavizadeh H,Abbasi A,Ayati Z,Jaafari MR

    更新日期:2013-04-01 00:00:00

  • Pharmacokinetics of a Standardized Extract of Centella asiatica ECa 233 in Rats.

    abstract::ECa 233, a standardized extract of Centella asiatica, has been found to exhibit various positive neurological effects and to have a good safety profile. The present study aimed to explore the disposition kinetics of ECa 233, containing madecassoside (53.1 %) and asiaticoside (32.3 %), in rats. The extract was intraven...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0042-122344

    authors: Anukunwithaya T,Tantisira MH,Tantisira B,Khemawoot P

    更新日期:2017-05-01 00:00:00

  • Hydrolysis is the dominating in vivo metabolism pathway for arctigenin: identification of novel metabolites of arctigenin by LC/MS/MS after oral administration in rats.

    abstract::The phenylpropanoid dibenzylbutyrolactone lignan arctigenin, a key component found in Arctium lappa, or burdock, has been reported with a variety of therapeutic effects including anticancer, anti-inflammation, and antivirus effects. Using LC/MS/MS, three novel metabolites of arctigenin, namely, arctigenic acid, arctig...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1328332

    authors: Gao Q,Zhang Y,Wo S,Zuo Z

    更新日期:2013-04-01 00:00:00

  • Polyphenolic constituents from the leaves of two Cynara species growing in Greece.

    abstract::The chemical analyses of two Cynara species: C. humilis and C.cornigera revealed various combinations of flavones, flavonols, flavanones, coumarins, phenolic acids, and an aurone. All the identified constituents are reported for the first time from the two species, while the presence of the aurone is reported for the ...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-957738

    authors: Chinou I,Harvala C

    更新日期:1997-10-01 00:00:00

  • Protein tyrosine phosphatase 1B (PTP1B)-inhibiting constituents from the leaves of Syzygium polyanthum.

    abstract::A methanol extract of the leaves of Syzygium polyanthum (Wight) Walp. afforded four new acylbenzene derivatives (1-4) together with seven known compounds (5-11). The structures of 1-11 were elucidated by extensive spectroscopic methods and comparison with the literature data. The new compounds 1-3 and a known compound...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1315000

    authors: Saifudin A,Tanaka K,Kadota S,Tezuka Y

    更新日期:2012-08-01 00:00:00

  • Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells.

    abstract::The involvement of unfolded protein response (UPR) activation in tumor survival and resistance to chemotherapies suggests a new anticancer strategy targeting UPR pathway. Arctigenin, a natural product, has been recently identified for its antitumor activity with selective toxicity against cancer cells under glucose st...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1250179

    authors: Sun S,Wang X,Wang C,Nawaz A,Wei W,Li J,Wang L,Yu DH

    更新日期:2011-01-01 00:00:00

  • Sesquiterpenoids from Inula racemosa Hook. f. inhibit nitric oxide production.

    abstract::A novel trinorsesquiterpene (1), three new (2-4), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibit...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0031-1280294

    authors: Zhang SD,Qin JJ,Jin HZ,Yin YH,Li HL,Yang XW,Li X,Shan L,Zhang WD

    更新日期:2012-01-01 00:00:00

  • Topical application of luteolin inhibits scratching behavior associated with allergic cutaneous reaction in mice.

    abstract::The present study is aimed at evaluating the effects of luteolin on the scratching behavior associated with an allergic cutaneous reaction in mice. Elicitation of passive cutaneous anaphylaxis, and intradermal injections of compound 48/80, histamine or serotonin induced scratching behavior in ICR mice. Models of irrit...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2005-864137

    authors: Baolin L,Weiwei W,Ning T

    更新日期:2005-05-01 00:00:00

  • Flow Cytometric Analysis of Cellular Berberine Contents in High- and Low-Producing Cell Lines of Coptis japonica Obtained by Repeated Selection.

    abstract::Cell lines that were highly productive for berberine were selected by repeated cloning of small cell aggregates. The berberine content of the highest-producing cell line increased after 4 clonings to 10% dw in comparison to the 3% dw found for the parent line, and the berberine yield was about 1,500 mg/1/14 days. Ther...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-961910

    authors: Hara Y,Yamagata H,Morimoto T,Hiratsuka J,Yoshioka T,Fujita Y,Yamada Y

    更新日期:1989-04-01 00:00:00

  • Radical scavengers from the entomogenous deuteromycete Beauveria amorpha.

    abstract::The culture medium of Beauveria amorpha Hohn. exhibited strong radical scavenging properties. Activity-directed fractionation assisted by a radical scavenging assay on TLC afforded two active compounds which were identified as 6-methyl-2,4-dihydroxyphenyl 4-O-methyl-beta-D-glucopyranoside (1) and (-)-terredionol (2). ...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2002-19868

    authors: Hu F,Schmidt K,Stoyanova S,Zengzhi L,Gräfe U,Hamburger M

    更新日期:2002-01-01 00:00:00

  • Bioactive coumarin derivatives from the fern Cyclosorus interruptus.

    abstract::Three new coumarin derivatives, compounds 1-3, three new furanocoumarins, compounds 4-6, and a novel dioxocane derivative, compound 7, were isolated from the fern Cyclosorus interruptus (Willd.) H. Itô. Based on spectrometric and spectroscopic analysis (FAB or El mass spectrometry as well as 1D and 2D NMR experiments)...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2000-9908

    authors: Quadri-Spinelli T,Heilmann J,Rali T,Sticher O

    更新日期:2000-12-01 00:00:00

  • Antitumoral Activity of (20R)- and (20S)-Ginsenoside Rh2 on Transplanted Hepatocellular Carcinoma in Mice.

    abstract::Hepatocellular carcinoma is one of the leading causes of malignancy-related death in China. Its therapy in clinics is a big challenge. Ginsenoside Rh2 is one of the most notable cancer-preventing components from red ginseng and it has been reported that ginsenoside Rh2 exhibited potent cytotoxicity against human hepat...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0042-101764

    authors: Lv Q,Rong N,Liu LJ,Xu XL,Liu JT,Jin FX,Wang CM

    更新日期:2016-05-01 00:00:00

  • Nuciferine Relaxes Tracheal Rings via the Blockade of VDLCC and NSCC Channels.

    abstract::This study aimed to elucidate the mechanisms of nuciferine (a main aporphine alkaloid of lotus leaf extract), which can induce relaxation in contracted tracheal rings. Under Ca2+-free and 2 mM Ca2+ conditions, we found that nuciferine had no effect on the resting muscle tone of tracheal rings. In contrast, nuciferine ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0043-118178

    authors: Yang X,Yu MF,Lei J,Peng YB,Zhao P,Xue L,Chen W,Ma LQ,Liu QH,Shen J

    更新日期:2018-01-01 00:00:00

  • Prevention of hydrogen peroxide damage by soybean saponins to mouse fibroblasts.

    abstract::Soybean saponin is one of several soybean glycosides. Recently, new soybean saponins which possess the DDMP (2,5-dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one) moiety have been detected. Soyasaponin beta g of these new soybean saponins was shown to inhibit hydrogen peroxide damage to mouse fibroblast cells. Not only t...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957871

    authors: Yoshikoshi M,Yoshiki Y,Okubo K,Seto J,Sasaki Y

    更新日期:1996-06-01 00:00:00

  • Aquaticol, a bis-sesquiterpene and iridoid glucosides from Veronica anagallis-aquatica.

    abstract::Aquaticol, an unusual bis-sesquiterpene was isolated from the medicinal plant Veronica anagallis-aquatica, in addition to 11 known compounds, aucubin, geniposidic acid, mussaenoside, catalposide, verproside, amphicoside, catalpol, boschnaloside, shanzhiside methyl ester, sitosterol and beta-stigmast-4-en-6 beta-ol-3-o...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2000-8564

    authors: Su BN,Yang L,Gao K,Jia ZJ

    更新日期:2000-04-01 00:00:00

  • Essential Oil of Chrysanthemum indicum.

    abstract::The steam distilled oils both from flowers and leaves, as well as from total aerial parts of CHRYSANTHEMUM INDICUM L. (small-flowered form), were obtained and analyzed by GC and GC/MS. Their main components are borneol, chrysanthenone and bornyl acetate. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969858

    authors: Stoianova-Ivanova B,Budzikiewicz H,Koumanova B,Tsoutsoulova A,Mladenova K,Brauner A

    更新日期:1983-12-01 00:00:00

  • The natural olive constituent oleuropein induces nutritional cardioprotection in normal and cholesterol-fed rabbits: comparison with preconditioning.

    abstract::Ischemic preconditioning, which is mediated by cell signaling molecules, protects the heart from ischemia-reperfusion injury by limiting the infarct size. Oleuropein, the main polyphenolic constituent of olives, reduced the infarct size in normal and cholesterol-fed rabbits when it was administered at a nutritional do...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0034-1383306

    authors: Andreadou I,Benaki D,Efentakis P,Bibli SI,Milioni AI,Papachristodoulou A,Zoga A,Skaltsounis AL,Mikros E,Iliodromitis EK

    更新日期:2015-06-01 00:00:00

  • Antioxidant activity of curtisians I-L from the inedible mushroom Paxillus curtisii.

    abstract::Four p-terphenyl derivatives named curtisians I-L (1-4) were isolated from the MeOH extract of the fruit bodies of Paxillus curtisii. Their structures were elucidated by 2D NMR, MS, IR and UV spectroscopy and chemical reaction. The absolute configurations of curtisians were determined by GC-MS on a chiral column of th...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2003-45159

    authors: Quang DN,Hashimoto T,Nukada M,Yamamoto I,Tanaka M,Asakawa Y

    更新日期:2003-11-01 00:00:00

  • Induction of cytochrome P450s by rutaecarpine and metabolism of rutaecarpine by cytochrome P450s.

    abstract::Rutaecarpine is an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa. Recently, rutaecarpine has been characterized to have an anti-inflammatory activity through cyclooxygenase-2 inhibition. In the present studies, the effects of rutaecarpine on liver cytochrome P450 s (P450s) and P450 s involved...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2004-827207

    authors: Lee SK,Kim NH,Lee J,Kim DH,Lee ES,Choi HG,Chang HW,Jahng Y,Jeong TC

    更新日期:2004-08-01 00:00:00