Abstract:
:Four diterpenoids, carnosic acid (1), carnosol (2), rosmanol (3), and epirosmanol (4), were isolated as antioxidative agents from the leaves of Rosmarinus officinalis by bioassay-directed fractionation. These diterpenoids inhibited superoxide anion production in the xanthine/xanthine oxidase system. Mitochondrial and microsomal lipid peroxidation induced by NADH or NADPH oxidation were also completely inhibited by these diterpenes at the concentration of 3-30 microM. Furthermore, carnosic acid protected red cells against oxidative hemolysis. These phenolic diterpenes were shown to be effective to protect biological systems against oxidative stresses.
journal_name
Planta Medjournal_title
Planta medicaauthors
Haraguchi H,Saito T,Okamura N,Yagi Adoi
10.1055/s-2006-958094subject
Has Abstractpub_date
1995-08-01 00:00:00pages
333-6issue
4eissn
0032-0943issn
1439-0221journal_volume
61pub_type
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