Abstract:
:A phytochemical study of the roots of Pongamia pinnata afforded 29 flavanones and flavanols, including 7 previously undescribed compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and mass spectroscopy data. The absolute configurations of the compounds were assigned via analysis of the specific rotations and electronic circular dichroism spectra, application of Mosher's method, and by comparing the calculated and experimental electronic circular dichroism spectra. The isolates were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells. All of the isolated compounds exhibited inhibitory effects against nitric oxide production, and most of them showed obvious anti-inflammatory activities (IC50 < 20 µM), among which 26: was the most active compound with an IC50 of 9.6 µM.
journal_name
Planta Medjournal_title
Planta medicaauthors
Wen R,Lv H,Jiang Y,Tu Pdoi
10.1055/a-0626-7356subject
Has Abstractpub_date
2018-11-01 00:00:00pages
1174-1182issue
16eissn
0032-0943issn
1439-0221journal_volume
84pub_type
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