Abstract:
:Six new neo-clerodane diterpenoids (1: -6: ), scutebatas X - Z, A1-C1, along with twelve known ones (7: -18: ) were obtained via the phytochemical investigation of the aerial parts of Scutellaria barbata. Their structures were established by detailed spectroscopic analysis. The absolute configurations of 1: and 2: , as the representative members of this type, were identified based on a circular dichroic exciton chirality method. Moreover, in vitro cytotoxicity of compounds 1: -6: were evaluated against three human cancer cell lines (SGC-7901, MCF-7, and A-549) using the MTT method. Compound 6: showed cytotoxic activities against all the three cell lines with IC50 values of 17.9, 29.9, and 35.7 µM, respectively.
journal_name
Planta Medjournal_title
Planta medicaauthors
Yang GC,Hu JH,Li BL,Liu H,Wang JY,Sun LXdoi
10.1055/a-0638-8255subject
Has Abstractpub_date
2018-11-01 00:00:00pages
1292-1299issue
17eissn
0032-0943issn
1439-0221journal_volume
84pub_type
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