Abstract:
:[6]-Gingerol potently inhibits peroxynitrite-induced oxidation and nitration reactions, but its mechanism of action is unclear. In order to discover the mechanism of inhibition, [6]-gingerol was reacted with peroxynitrite and the reaction mixture was analyzed using HPLC. The HPLC chromatogram showed one novel peak, indicative of the formation of a reaction product between [6]-gingerol and peroxynitrite. This compound was purified and identified as a symmetrical dimer of [6]-gingerol covalently linked at the aromatic ring. It has been assumed that this dimer is generated from a phenoxyl radical intermediate produced from [6]-gingerol via one-electron oxidation by peroxynitrite-derived radicals. We propose a mechanism in which [6]-gingerol scavenges peroxynitrite-derived radicals and consequently inhibits peroxynitrite-induced oxidation and nitration reactions.
journal_name
Planta Medjournal_title
Planta medicaauthors
Ippoushi K,Ito H,Horie H,Azuma Kdoi
10.1055/s-2005-864160subject
Has Abstractpub_date
2005-06-01 00:00:00pages
563-6issue
6eissn
0032-0943issn
1439-0221journal_volume
71pub_type
杂志文章相关文献
PLANTA MEDICA文献大全abstract::A novel experimental model of free radical-induced emesis for screening anti-emetic compounds from natural sources was established. 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) dissolved in liposome induced emesis in young chickens, and the emesis was prevented by antioxidants including N-(2-mercaptopropionyl)...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960829
更新日期:1999-08-01 00:00:00
abstract::Comparative study of the seeds of two Cucurbitaceae Momordica charantia L. and Herpetospermum caudigerum Wall. shows and important difference for their metabolism concerning particularly aspartic acid. Momordica can produce vicin, while for Herpetospermum, this amino acid would give asparagin. In the other hand, betwe...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971211
更新日期:1982-11-01 00:00:00
abstract::Callus induction starting from the rhizome tissue of plants of three CURCUMA species: CURCUMA ZEDOARIA Roscoe, C. DOMESTICA Valeton, and C. AROMATICA Salisbury (Zingiberaceae) was performed. Successful callus formation was obtained in all three species using Murashige-Skoog's (MS) medium supplemented with 1-naphthalen...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-962344
更新日期:1988-02-01 00:00:00
abstract::From roots of Rubia cordifolia L. four anthraquinones are isolated: 1-hydroxy 2-methoxy anthraquinone; 1,4-dihydroxy 2-methyl 5-methoxy anthraquinone or 1,4-dihydroxy 2-methyl 8-methoxy anthraquinone; 1,3-dimethoxy 2-carboxy anthraquinone and rubiadin. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971524
更新日期:1981-12-01 00:00:00
abstract::Arctigenin is a phenylpropanoid dibenzylbutyrolactone lignan compound possessing antitumor, anti-inflammatory, anti-influenza, antioxidant, antibacterial, and hypoglycaemic activities. Our previous study demonstrated that arctigenin exerts neuroprotective effects both in vitro and in vivo in a Parkinson's disease mode...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-107471
更新日期:2017-01-01 00:00:00
abstract::Three new compounds, namely, (+)-dihydrodehydrodiconiferyl alcohol 4- O- beta-(6''- O-galloyl)-glucopyranoside ( 1), 4,4'- O-dimethylellagic acid 3-(2''- O-acetyl)- alpha-rhamnopyranoside ( 2), and ethyl O- beta-(6'-galloyl)-glucopyranoside ( 3), together with eleven known ones, were isolated from the stem bark of Tre...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2008-1034361
更新日期:2008-03-01 00:00:00
abstract::New phloroglucinol derivatives were isolated from the ethanolic extract of ECKLONIA MAXIMA, a brown alga found off the west coast of South Africa. Most of these compounds contain dibenzo[1,4]dioxin elements. The common basic unit of all the compounds found is eckol, a hexahydroxyphenoxydibenzo[1,4]dioxin composed of 3...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969498
更新日期:1985-08-01 00:00:00
abstract::Turmeric has been extensively utilized in Indian and Chinese medicine for its immune-modulatory properties. Dendritic cells (DCs) are antigen-presenting cells specialized to initiate and regulate immunity. The ability of DCs to initiate immunity is linked to their activation status. The effects of turmeric on human DC...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0028-1088367
更新日期:2009-03-01 00:00:00
abstract::Acetonylgeraniin, an active principle isolated from the seeds of Euphoria longana Lam. (Sapindaceae), reversed the fall in arterial blood pressure in conscious hypertensive rats (SHRs) with orthostatic hypotension induced by injection of hexamethonium into animals subjected to 90 degrees head-up tilts for 60 seconds. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-959487
更新日期:1994-08-01 00:00:00
abstract::TLC autographic assays revealed in the CH(2)Cl(2) extract of Tinospora crispa Miers (Menispermaceae) the presence of three compounds exhibiting antioxidant and radical scavenging properties towards beta-carotene and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. They were isolated and identified as N-CIS-feruloyltyrami...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957466
更新日期:1998-06-01 00:00:00
abstract::Helanalin, a sesquiterpene lactone antineoplastic agent, is toxic at therapeutic doses in murine tumors. The toxicity has been assumed to be correlated with the binding of the drug to cellular thiol groups. Studies were undertaken to increase the intracellular level of GSH in the liver, kidney and other tissues to eli...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-962083
更新日期:1989-12-01 00:00:00
abstract::Five new dibenzocyclooctane lignans, schisanwilsonins K-O, together with eighteen known lignans were isolated from the stems of Schisandra wilsoniana. The structures of these new compounds were elucidated by spectroscopic methods, including 2D-NMR techniques. Several compounds were found to show anti-HIV and anti-HBV ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328747
更新日期:2013-08-01 00:00:00
abstract::A cytotoxic compound was purified from the root of Angelica gigas Nakai by normal phase HPLC. As a result of the structure analysis by mass, IR, 1H-NMR, and 13C-NMR spectrometry, the compound was identified as decursinol angelate, a structural isomer of decursin, and characterized originally from Sesei grandivittatum....
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-957701
更新日期:1997-08-01 00:00:00
abstract::Stabilization of growth factors in a wound environment is critical to the wound healing process. Here we report on the stabilization of key growth factors by a unique plant cell wall biomaterial. MicroSheets are clear cell wall fragments isolated from the non-living water storage cells in the pulp or inner gel of Aloe...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-990225
更新日期:2007-10-01 00:00:00
abstract::Tissue callus cultures originating from CHELIDONIUM MAJUS L. seeds were established on Gamborg B5, Murashige-Skoog (MS), and Schenk-Hildebrandt (SH) media. In all experimental conditions, calli accumulated a complex pattern of isoquinoline derivatives. The highest values, both in growth and in sanguinarine production,...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960141
更新日期:1991-10-01 00:00:00
abstract::Immune complex binding to macrophages was enhanced by treatment with an E. kansui extract. Systematic fractionation of the extract led to the characterization of 3-O-(2'E,4'Z-decadienoyl)- and 3-O-(2,3-dimethylbutyryl)-13- O-n-dodecanoyl-13-hydroxyingenol as the active principles. Immune complex binding to macrophages...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-961447
更新日期:1992-06-01 00:00:00
abstract::A total of 37 commercial samples of Ginseng Radix, the origins of which belonged to Panax ginseng C. A. Meyer, P. quinquefolia Linn. (American ginseng), and P. notoginseng Burkill (sanchi-ginseng), respectively, were collected from the Taiwan herbal markets. The contents of nine ginsenosides, Rb(1), Rb(2), Rc, Rd, Re,...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-958137
更新日期:1995-10-01 00:00:00
abstract::PAPAVER SOMNIFERUM L. tissue cultures, issued from various explants (cotyledons, hypocotyls, roots) derived from plantlets belonging to two genotypes, were established on LS solid medium containing growth regulators (NAA, Kin) in various combinations. Hypocotyls and roots were found to be interesting explants to obtai...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960457
更新日期:1999-03-01 00:00:00
abstract::Volatile constituents of the essential oils from leaves and inflorescences of Solidago chilensis Meyen were analyzed by GC-FID, GC-MS and 13C-NMR and thirty-six different compounds were identified. Pumiloxide, an unusual labdane diterpene, was found to be one of the major components in both oils (15.3 % and 12.3 %, re...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2002-20253
更新日期:2002-02-01 00:00:00
abstract::We have previously shown that 11 ent-kauranes isolated from the stems of Annona squamosa exhibited immunomodulating effects in leukocytes. In this study, a cellular model using isolated human neutrophils, which are important in the pathogenesis of rheumatoid arthritis, ischemia-reperfusion injury, chronic obstructive ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-871234
更新日期:2005-10-01 00:00:00
abstract::The culture medium of Beauveria amorpha Hohn. exhibited strong radical scavenging properties. Activity-directed fractionation assisted by a radical scavenging assay on TLC afforded two active compounds which were identified as 6-methyl-2,4-dihydroxyphenyl 4-O-methyl-beta-D-glucopyranoside (1) and (-)-terredionol (2). ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2002-19868
更新日期:2002-01-01 00:00:00
abstract::Astilbin, a flavonoid compound, was isolated from the rhizome of Smilax glabra Roxb. This study was conducted to investigate the efficacy of astilbin on experimental diabetic nephropathy (DN) in vivo and in vitro and its possible mechanisms. Astilbin was added in high glucose stimulated HK-2 cells, streptozotocin-indu...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1185802
更新日期:2009-11-01 00:00:00
abstract::Khat (Catha edulis Forsk.) is a perennial shrub whose young leaves are chewed for their psychostimulating and anorectic properties. The main active principles of khat are believed to be the phenylpropylamino alkaloids, primarily (-)-cathinone [(S)-α-aminopropiophenone], (+)-cathine [(1S)(2S)-norpseudoephedrine], and (...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1298430
更新日期:2012-05-01 00:00:00
abstract::Three steroidal saponins, including astrogorgiosides A (1) and B (2) bearing acetamido-glucose moieties, and astrogorgioside C (3) with a 19-nor and bearing an aromatized B ring steroid aglycone, together with a known major saponin dimorphoside A (4), were obtained from the gorgonian Astrogorgia dumbea collected near ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-106168
更新日期:2016-06-01 00:00:00
abstract::Plectranthus barbatus Andr. is one of the most important species of the genus Plectranthus L' Herit. (Lamiaceae), with a wide variety of traditional medicinal uses in Hindu and Ayurvedic traditional medicine as well as in the folk medicine of Brazil, tropical Africa and China. The plant has therefore been an attractiv...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0029-1240898
更新日期:2010-05-01 00:00:00
abstract::A phytochemical study of the roots of Pongamia pinnata afforded 29 flavanones and flavanols, including 7 previously undescribed compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and mass spectroscopy data. The absolute configurations of the compounds were assigned via analysis of the...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-0626-7356
更新日期:2018-11-01 00:00:00
abstract::Flavonoids, important components of human diet, have been claimed to possess a significant antiplatelet potential, in particular due to their effects on the arachidonic acid cascade. Due to variable and incomplete results, this study was aimed at delivering a detailed analysis of the effects of 29 structurally relevan...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1557902
更新日期:2016-01-01 00:00:00
abstract::The inhibitory effects of selected phenolic lichen substances were tested against a panel of methicillin- and multidrug-resistant Staphylococcus aureus. Depsidones with long alkyl chains on both of the aromatic rings were consistently active against the strains tested, comparable to or better than the level of clinica...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957070
更新日期:2007-02-01 00:00:00
abstract::Eight compounds were isolated from the CH (2)Cl (2) extracts of ERYTHRINA SENEGALENSIS to assess HIV-1 protease (PR) activity inhibition. The prenylated isoflavone structures, identified by spectroscopic analysis, were 8-prenylluteone ( 1), auriculatin ( 2), erysenegalensein O ( 3), erysenegalensein D ( 4), erysenegal...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0028-1088395
更新日期:2009-02-01 00:00:00
abstract::The activity-guided fractionation of the hydroalcoholic extract of trunk bark of Cedrelopsis grevei led to the isolation of five coumarins, norbraylin (1), methyl-O-cedrelopsin (2), cedrecoumarin A (3), scoparone (4) and braylin (5) as a part of the constituents responsible for the vasorelaxing activity observed for t...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2003-37717
更新日期:2003-02-01 00:00:00