Selective estrogen receptor modulators and phytoestrogens.

Abstract:

:Scientific achievements in the last two decades have revolutionized the treatment and prevention of breast cancer. This is mainly because of targeted therapies and a better understanding of the relationship between estrogen, its receptor, and breast cancer. One of these discoveries is the use of synthetic selective estrogen modulators (SERMs) such as tamoxifen in the treatment strategy for estrogen receptor (ER)-positive breast cancer. Hundreds of thousands of lives have been saved because of this advance. Not only is tamoxifen used in the treatment strategy for patients who have breast cancer, but also for prevention in high-risk premenopausal women. Another synthetic SERM, raloxifene, which was initially used to prevent osteoporosis, is also as effective as tamoxifen for prevention in high-risk postmenopausal women. In certain regions of the world, particularly in Asia, a low incidence of breast cancer has been observed. These women have diets that are high in soy and low in fat, unlike the Western diet. Interest in the protective effects of soy derivatives has led to the research of phytoestrogens and metabolites of soy that are described by some as natural SERMs. As a result, many clinical questions have been raised as to whether phytoestrogens, which are also found in other natural foods, can protect against breast cancer. This article reviews the development and role of the more common SERMs, tamoxifen and raloxifene. In addition, this paper will also highlight the emerging studies on phytoestrogens and their similarity and dissimilarity to SERMs.

journal_name

Planta Med

journal_title

Planta medica

authors

Oseni T,Patel R,Pyle J,Jordan VC

doi

10.1055/s-0028-1088304

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

1656-65

issue

13

eissn

0032-0943

issn

1439-0221

journal_volume

74

pub_type

杂志文章,评审
  • Flavonolignans, Kaempferol 3-Sulphate and Other Flavonoids from Silybum marianum subsp. anatolicum.

    abstract::Flavonolignan compounds have been isolated from the fruits of SILYBUM MARIANUM subsp. ANATOLICUM and kaempferol 3-sulphate and other flavonoid compounds have been isolated from the aerial parts and were identified. The flavonoid sulphate derivatives are shown to be present in SILYBUM genus for the first time. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-962330

    authors: Meriçli AH

    更新日期:1988-02-01 00:00:00

  • New oligospirostanosides and oligofurostanosides from Asparagus adscendens roots.

    abstract::The methanol extract of the defatted roots of Asparagus adscendens Roxb. yielded beta-sitosterol beta-D-glucoside, two new spirostanol glycosides (asparanin C and asparanin D) and two new furostanol glycosides (asparoside C and asparoside D). ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-970018

    authors: Sharma SC,Chand R,Bhatti BS,Sati OP

    更新日期:1982-09-01 00:00:00

  • The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions.

    abstract::A plant mixture containing extracts of Nigella sativa possesses blood glucose lowering effects, but the direct antidiabetic effect of Nigella sativa is not yet established. Therefore, the effect of Nigella sativa oil (NSO) on blood glucose concentrations was studied in streptozotocin diabetic rats. In addition, the ef...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2002-32084

    authors: El-Dakhakhny M,Mady N,Lembert N,Ammon HP

    更新日期:2002-05-01 00:00:00

  • Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from ginkgo biloba leaves.

    abstract::Ginkgetin, a biflavone isolated from Ginkgo biloba leaves, was previously reported as an inhibitor of group II phospholipase A2. In this study, ginkgetin was evaluated for in vivo antiarthritic and analgesic activities. Ginkgetin (10-20 mg/kg/day) strongly reduced arthritic inflammation in an animal model of rat adjuv...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-960815

    authors: Kim HK,Son KH,Chang HW,Kang SS,Kim HP

    更新日期:1999-06-01 00:00:00

  • Effects of estradiol benzoate, raloxifen and an ethanolic extract of Cimicifuga racemosa in nonclassical estrogen regulated organs of ovariectomized rats.

    abstract::The special extract of Cimicifuga racemosa (CR) BNO 1055 was shown to have bone protective effects without exerting estrogenic effects in the uterus or mammary gland. Whether the effects of CR BNO 1055 would be exerted in other organs that also express estrogen receptors (ERs) but in which the effects of estrogens and...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0029-1185561

    authors: Seidlova-Wuttke D,Jarry H,Wuttke W

    更新日期:2009-10-01 00:00:00

  • Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata.

    abstract::The immunomodulatory activity of HN-02, an extract containing a mixture of andrographolides (i.e., andrographolide [88 +/- 5 %] plus 14-deoxyandrographolide and 14-deoxy-11,12-didehydroandrographolide together [12 +/- 3 %]) in a pure powder form was evaluated at 1.0, 1.5, and 2.5 mg/kg on different in vivo and in vitr...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0029-1185398

    authors: Naik SR,Hule A

    更新日期:2009-06-01 00:00:00

  • Studies on the tissue culture of Stevia rebaudiana and its components; (II). Induction of shoot primordia.

    abstract::Shoot primordia, which were able to propagate vegetatively with a very high rate and to redifferentiate easily to new plants, were induced from shoot tips of Stevia rebaudiana Bertoni on Gamborg B5 medium containing 6-benzylaminopurine (BAP) and alpha-naphthaleneacetic acid (NAA) under light. The propagation of the sh...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969165

    authors: Miyagawa H,Fujioka N,Kohda H,Yamasaki K,Taniguchi K,Tanaka R

    更新日期:1986-08-01 00:00:00

  • Activity of quinones from teak (Tectona grandis) on fungal cell wall stress.

    abstract::Teak ( Tectona grandis L.f., Verbenaceae) sawdust extract inhibited the growth of Aspergillus niger. Centrifugal partition chromatography was used to isolate the active compounds. By (1)H-NMR the active compounds were identified as deoxylapachol and tectoquinone. Two A. niger transgenic strains which show induction of...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-946676

    authors: Sumthong P,Damveld RA,Choi YH,Arentshorst M,Ram AF,van den Hondel CA,Verpoorte R

    更新日期:2006-08-01 00:00:00

  • Somatic embryogenesis and rhizogenesis of tissue cultures of two genotypes of Papaver somniferum: relationships to alkaloids production.

    abstract::PAPAVER SOMNIFERUM L. tissue cultures, issued from various explants (cotyledons, hypocotyls, roots) derived from plantlets belonging to two genotypes, were established on LS solid medium containing growth regulators (NAA, Kin) in various combinations. Hypocotyls and roots were found to be interesting explants to obtai...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-960457

    authors: Laurain-Mattar D,Gillet-Manceau F,Buchon L,Nabha S,Fliniaux MA,Jacquin-Bubreuil A

    更新日期:1999-03-01 00:00:00

  • Acetylenes from Atractylis koreana.

    abstract::A reinvestigation of the rhizomes of ATRACTYLIS KOREANA afforded in addition to 1,3-diacetoxytetradeca-6,12-diene-8,10-diyne reported previously (1) two new C (14)-polyacetylenes with an ene-diyn-ene-chromophor and one new C (14)-polyacetylene beside two known compounds with an ene-diyne-diene-chromophor. Their struct...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-961013

    authors: Pachaly P,Lansing A,Neugebauer M,Sin KS

    更新日期:1990-10-01 00:00:00

  • A simple and efficient separation of the curcumins, the antiprotozoal constituents of Curcuma longa.

    abstract::A simple and efficient method for the separation of the three phenolic diketones, curcumin 1, demethoxycurcumin 2, and bis-demethoxycurcumin 3, isolated from the rhizomes of Curcuma longa has been developed. The method is of general applicability for the separation of compounds containing acidic and chelating groups a...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2000-8533

    authors: Rasmussen HB,Christensen SB,Kvist LP,Karazmi A

    更新日期:2000-05-01 00:00:00

  • Topical application of luteolin inhibits scratching behavior associated with allergic cutaneous reaction in mice.

    abstract::The present study is aimed at evaluating the effects of luteolin on the scratching behavior associated with an allergic cutaneous reaction in mice. Elicitation of passive cutaneous anaphylaxis, and intradermal injections of compound 48/80, histamine or serotonin induced scratching behavior in ICR mice. Models of irrit...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2005-864137

    authors: Baolin L,Weiwei W,Ning T

    更新日期:2005-05-01 00:00:00

  • Characterization of Casearin X Metabolism by Rat and Human Liver Microsomes.

    abstract::Casearin X (CAS X) is the major clerodane diterpene isolated from the leaves of Casearia sylvestris and has been extensively studied due to its powerful cytotoxic activity at low concentrations. Promising results for in vivo antitumor action have also been described when CAS X was administered intraperitoneally in mic...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-0765-9523

    authors: Moreira da Silva R,de Gaitani CM,Marques LMM,Fraige Baraco K,Cavalheiro AJ,de Moraes LAB,Lopes NP,de Oliveira ARM

    更新日期:2019-03-01 00:00:00

  • Nematicidal activities of two phytoalexins from Taverniera abyssinica.

    abstract::The traditional analgesic and antipyretic Ethiopian drug "Dingetegna" is made of dried root material of Taverniera abyssinica A. Rich (Leguminosae). In a screening for nematicidal natural products, "Dingetegna" extracts showed strong nematicidal activities towards C. elegans. In the following, medicarpin and 4-hydroxy...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-959569

    authors: Stadler M,Dagne E,Anke H

    更新日期:1994-12-01 00:00:00

  • Determination of naphthazarin derivatives in endemic Turkish Alkanna species by reversed phase high performance liquid chromatography.

    abstract::The quantification of free and total alkannins in 13 endemic Anatolian Alkanna species is described for the first time. Extraction of the samples was performed by sonication with hexane, followed by hydrolysis in 1 N NaOH. For analysis, a new HPLC method, utilizing reversed phase material (Synergi Max RP), was develop...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-967110

    authors: Pekin G,Ganzera M,Senol S,Bedir E,Korkmaz KS,Stuppner H

    更新日期:2007-03-01 00:00:00

  • The inhibitory effects of jujuboside A on rat hippocampus in vivo and in vitro.

    abstract::Jujuboside A (JuA) is a glycoside extracted from the seed of Ziziphus jujuba Mill var. spinosa (Bunge) Hu ex H F Chou, a Chinese herbal medicine, which has long been known as a sedative-hypnotic drug. The present study used the method of intracerebroventricular (i.c.v.) JuA in vivo to detect the effect of JuA on paire...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2002-34398

    authors: Shou C,Feng Z,Wang J,Zheng X

    更新日期:2002-09-01 00:00:00

  • Two new derivatives of griseofulvin from the mangrove endophytic fungus Nigrospora sp. (strain No. 1403) from Kandelia candel (L.) Druce.

    abstract::Two new compounds, methyl 3-chloro-6-hydroxy-2-(4-hydroxy-2-methoxy-6-methylphenoxy)-4-methoxybenzoate (1) and (2 S,5' R,E)-7-hydroxy-4,6-dimethoxy-2-(1-methoxy-3-oxo-5-methylhex-1-enyl)-benzofuran-3(2H)-one (2), together with four known compounds, griseofulvin (3), dechlorogriseofulvin (4), bostrycin (5), and deoxybo...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1271040

    authors: Xia X,Li Q,Li J,Shao C,Zhang J,Zhang Y,Liu X,Lin Y,Liu C,She Z

    更新日期:2011-10-01 00:00:00

  • New Phenolic Derivatives from Galeola faberi.

    abstract::Seven phenolic derivatives, 2,4-bis(4-hydroxybenzyl)phenol ( 1), bis[4(beta- D-glucopyranosyloxy)-benzyl] ( S)-(-)-2-isopropylmalate ( 2), bis[4-(beta- D-gluco-pyranosyloxy)benzyl] ( S)-(-)-2-sec-butylmalate ( 3), 4-hydroxybenzyaldehyde ( 4), 4,4'-dihydroxydiphenyl-methane ( 5), 4-hydroxybenzyl alcohol ( 6), and 4-(be...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-959702

    authors: Yi-Ming L,Zhuo-Lun Z,Yong-Fu H

    更新日期:1993-08-01 00:00:00

  • Cardioprotection and matrix metalloproteinase-9 regulation of salvianolic acids on myocardial infarction in rats.

    abstract::Acute myocardial infarction (AMI) remains the leading cause of mortality in the world. Early intervention using salvianolic acids (SA) can substantially improve clinical outcomes. However, in spite of the great achievements that have been made in elucidating the protective effects of SA on AMI, the effects of SA on th...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0029-1185669

    authors: Jiang B,Wu W,Li M,Xu L,Sun K,Yang M,Guan S,Liu X,Guo DA

    更新日期:2009-10-01 00:00:00

  • Protective Effect of Silybum marianum and Silibinin on Endothelial Cells Submitted to High Glucose Concentration.

    abstract::Silybum marianum Gaertn. (Milk thistle) has been used since ancient times for the relief of liver diseases characterized by intense oxidative stress such as inflammatory liver disease and cirrhosis. As oxidative stress by hyperglycemia is involved in micro- and macrovascular complications of type 2 diabetes, our aim w...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0042-113135

    authors: Palomino OM,Gouveia NM,Ramos S,Martín MA,Goya L

    更新日期:2017-01-01 00:00:00

  • The effect of medium constituents on growth and diosgenin production by Dioscorea deltoidea cells grown in batch cultures.

    abstract::The effect of nitrogen and carbon sources on growth and diosgenin production was studied with Dioscorea deltoidea cells which were grown under defined conditions in a chemostat, and transferred to batch cultures. Both ammonium and nitrate nitrogen were required for growth and steroid production; diosgenin production w...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-971414

    authors: Tal B,Gressel J,Goldberg I

    更新日期:1982-02-01 00:00:00

  • Growth inhibition and G1 cell cycle arrest mediated by 25-methoxyhispidol A, a novel triterpenoid, isolated from the fruit of Poncirus trifoliata in human hepatocellular carcinoma cells.

    abstract::Poncirus trifoliata (Rutaceae) extracts have been known to possess anti-allergic, anti-inflammatory and antiviral activities. However, other biological activities, especially, the anticancer potential of extracts of P. trifoliata or its constituents, have not been fully investigated yet. In this study, we have evaluat...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034286

    authors: Hong J,Min HY,Xu GH,Lee JG,Lee SH,Kim YS,Kang SS,Lee SK

    更新日期:2008-02-01 00:00:00

  • Inhibition of butyrylcholinesterase activity by some isoquinoline alkaloids.

    abstract::The inhibition of butyrylcholinesterase activity in human serum by protoberberine, benzophenanthridine and aporphine alkaloids as well as four model compounds has been studied. The mechanism of the inhibition is discussed on the basis of the different types of interaction of these compounds with butyrylcholinesterase ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969916

    authors: Ulrichová J,Walterová D,Preininger V,Simánek V

    更新日期:1983-07-01 00:00:00

  • Desorption/Chemical ionization mass spectrometry of bitter glycosides from gentiana1.

    abstract::A series of bitter secoiridoid glucosides isolated from various GENTIANA species (Gentianaceae) have been investigated by D/CI-MS. Amarogentin, amaropanin, amaroswerin, deglucosyltrifloroside, desacetylcentapicrin, gentiopicrin, swertiamarin and sweroside have been characterized by quasimolecular ions and typical frag...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969748

    authors: Schaufelberger D,Domon B,Hostettmann K

    更新日期:1984-10-01 00:00:00

  • [A comparative study of the effects of selection and environmental factors on alkaloid accumulation in strains of Choisya ternata].

    abstract::The accumulation of two dihydrofuroquinoline alkaloids has been studied in seventeen strains of Choisya ternata (Rutaceae) initiated from the same tree. The contents of platydesminium and balfourodinium vary in heavy proportions. The effect of some factors (age of the culture, NAA or glucose concentrations of the medi...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-971221

    authors: Gras M,Crèche J,Chénieux JC,Rideau M

    更新日期:1982-12-01 00:00:00

  • Encelin: a fungal growth inhibitor.

    abstract::A known sesquiterpene lactone, encelin, isolated from the Mexican species Montanoa speciosa (Compositae), was assayed for biocidal activity on fungal cells of Mucor rouxii. The results indicate that encelin has a determining action on growth and the morphogenetic process of fungal cells. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-958046

    authors: Sabanero M,Quijano L,Rios T,Trejo R

    更新日期:1995-04-01 00:00:00

  • Accumulation of hydrolyzable tannins by Aleurites fordii callus culture.

    abstract::A callus culture of Aleurites fordii Hemsley (Euphorbiaceae) producing five galloylglucoses and an ellagitannin, geraniin, was established. The production of pentagalloylglucose was remarkably enhanced under light irradiation compared with that in the dark. Cell growth and tannin production were also greatly affected ...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2002-36348

    authors: Taniguchi S,Uechi K,Kato R,Ito H,Hatano T,Yazaki K,Yoshida T

    更新日期:2002-12-01 00:00:00

  • Effects of the olive tree leaf constituents on myocardial oxidative damage and atherosclerosis.

    abstract::The olive (Olea europaea) leaf is considered an important traditional herbal medicine utilized against infectious diseases, and for the treatment of diabetes and hypertension. Moreover, olive leaf constituents have been related to cardioprotection, probably due to their association with cellular redox modulating effec...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-0035-1546017

    authors: Efentakis P,Iliodromitis EK,Mikros E,Papachristodoulou A,Dagres N,Skaltsounis AL,Andreadou I

    更新日期:2015-06-01 00:00:00

  • Bioavailability, pharmacokinetics, and tissue distribution of the oxypregnane steroidal glycoside P57AS3 (P57) from Hoodia gordonii in mouse model.

    abstract::P57AS3 (P57), an oxypregnane steroidal glycoside, is known to be responsible for the appetite suppressing activity of HOODIA GORDONII, a dietary supplement used for weight loss. In this study, bioavailability, pharmacokinetics, and tissue distribution of P57 were determined in CD1 female mice after administration of a...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1249818

    authors: Madgula VL,Ashfaq MK,Wang YH,Avula B,Khan IA,Walker LA,Khan SI

    更新日期:2010-10-01 00:00:00

  • 11-deoxyalisol C and alisol D: new protostane-type triterpenoids from Alisma plantago-aquatica.

    abstract::New protostane-type triterpenes, 11-deoxyalisol C and alisol D, have been isolated from the rhizomes of ALISMA PLANTAGO-AQUATICA, and their structures have been elucidated on the basis of spectral and chemical data. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-962495

    authors: Fukuyama Y,Pei-Wu G,Rei W,Yamada T,Nakagawa K

    更新日期:1988-10-01 00:00:00