Abstract:
:Mulberroside A, a major stilbene constituent of MORUS ALBA L. (Moraceae), displays significant antitussive and antiasthmatic effects in animals. As part of our ongoing research on its biotransformation in rats, mulberroside A was orally administered to rats, and the metabolites in the gastrointestinal contents and feces were investigated. Three major metabolites were isolated from the feces of rats and identified as oxyresveratrol-2- O- beta- D-glucopyranoside ( 1), oxyresveratrol-3'- O- beta- D-glucopyranoside ( 2), and oxyresveratrol ( 3) on the basis of chemical and spectroscopic evidence. The three metabolites were also detected in the small intestinal contents of rats following oral administration of mulberroside A. These findings suggest that mulberroside A is metabolized prior to absorption into the body.
journal_name
Planta Medjournal_title
Planta medicaauthors
Zhaxi M,Chen L,Li X,Komatsu K,Yao X,Qiu Fdoi
10.1055/s-0029-1186160subject
Has Abstractpub_date
2010-03-01 00:00:00pages
362-4issue
4eissn
0032-0943issn
1439-0221journal_volume
76pub_type
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