Three major metabolites of mulberroside A in rat intestinal contents and feces.

Abstract:

:Mulberroside A, a major stilbene constituent of MORUS ALBA L. (Moraceae), displays significant antitussive and antiasthmatic effects in animals. As part of our ongoing research on its biotransformation in rats, mulberroside A was orally administered to rats, and the metabolites in the gastrointestinal contents and feces were investigated. Three major metabolites were isolated from the feces of rats and identified as oxyresveratrol-2- O- beta- D-glucopyranoside ( 1), oxyresveratrol-3'- O- beta- D-glucopyranoside ( 2), and oxyresveratrol ( 3) on the basis of chemical and spectroscopic evidence. The three metabolites were also detected in the small intestinal contents of rats following oral administration of mulberroside A. These findings suggest that mulberroside A is metabolized prior to absorption into the body.

journal_name

Planta Med

journal_title

Planta medica

authors

Zhaxi M,Chen L,Li X,Komatsu K,Yao X,Qiu F

doi

10.1055/s-0029-1186160

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

362-4

issue

4

eissn

0032-0943

issn

1439-0221

journal_volume

76

pub_type

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