Abstract:
:Lead is a well-known toxin in the environment that causes severe damage to the nervous system. Gastrodin is the main bioactive component of Tian ma ( GASTRODIA ELATA Bl.), which is a traditional herbal medicine widely used in eastern Asia. Increasing lines of evidence show that gastrodin has diverse effects, especially neuroprotective effects. In the present study, we investigated whether gastrodin supplementation can rescue impairments of synaptic plasticity produced by developmental lead exposure. We examined three electrophysiological parameters of synaptic plasticity: input/output (I/O) function, paired-pulse facilitation (PPF), and long-term potentiation (LTP) of field excitatory postsynaptic potential (fEPSP) in the hippocampal CA1 region of rats on postnatal day 22 (P22). Our results showed that lead exposure significantly impaired synaptic plasticity in the hippocampal CA1 region and that gastrodin can effectively rescue these lead-induced impairments. Therefore, gastrodin may have potential therapeutic value for lead-induced impairments during human developmental stages.
journal_name
Planta Medjournal_title
Planta medicaauthors
Yong W,Xing TR,Wang S,Chen L,Hu P,Li CC,Wang HL,Wang M,Chen JT,Ruan DYdoi
10.1055/s-0029-1185452subject
Has Abstractpub_date
2009-08-01 00:00:00pages
1112-7issue
10eissn
0032-0943issn
1439-0221journal_volume
75pub_type
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