Abstract:
:The antiviral activities of two saponins, soyasaponin I and II, isolated from soybean (Glycine max Merrill) were studied in vitro against herpes simplex virus type 1 (HSV-1). Soyasaponin II was more potent than soyasaponin I as shown by reduction of HSV-1 production. Soyasaponin II was also found to inhibit the replication of human cytomegalovirus, influenza virus, and human immunodeficiency virus type 1. The action was not due to inhibition of virus penetration and protein synthesis, but might involve a virucidal effect. When acyclovir and soyasaponin II were evaluated in combination for anti-HSV-1 activity, additive antiviral effects were observed for this virus.
journal_name
Planta Medjournal_title
Planta medicaauthors
Hayashi K,Hayashi H,Hiraoka N,Ikeshiro Ydoi
10.1055/s-2006-957622subject
Has Abstractpub_date
1997-04-01 00:00:00pages
102-5issue
2eissn
0032-0943issn
1439-0221journal_volume
63pub_type
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