Abstract:
:Baicalein, berberine, curcumin and hesperidin are the major components derived from Scutellaria baicalensis, Coptis japonica, Curcuma longa and Poncirus trifoliata, respectively. These plants have been used for the treatment of diverse chronic inflammatory diseases including respiratory disease in oriental medicine and their respective major components were reported to have various biological effects including anti-inflammatory activity. In the present study, we investigated whether these four natural products affect mucin release from airway goblet cells and compared the possible activities of these agents with the inhibitory action on mucin release by PLL and the stimulatory action by ATP. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using 3H-glucosamine for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on 3H-mucin release. The results were as follows: (i) baicalein did not affect mucin release significantly; (ii) berberine, curcumin and hesperidin increased mucin release at the highest concentration (10 - 4 M); (iii) PLL inhibited and ATP increased mucin release. We conclude that berberine, curcumin and hesperidin can increase mucin release by directly acting on airway mucin-secreting cells and suggest that these agents be further studied for possible use as mild expectorants during the treatment of chronic airway diseases. Abbreviations. PLL:poly- L-lysine ATP:adenosine triphosphate HTSE:hamster tracheal surface epithelial DMSO:dimethylsulfoxide IL-12:interleukin-12 PBS:phosphate-buffered saline
journal_name
Planta Medjournal_title
Planta medicaauthors
Lee CJ,Lee JH,Seok JH,Hur GM,Park YC,Seol IC,Kim YHdoi
10.1055/s-2003-40655subject
Has Abstractpub_date
2003-06-01 00:00:00pages
523-6issue
6eissn
0032-0943issn
1439-0221journal_volume
69pub_type
杂志文章相关文献
PLANTA MEDICA文献大全abstract::The distribution and level of yew constituents vary with species and tissues. In this study, a rapid and valid method incorporating ultra-fast liquid chromatography (UFLC) with MS and UV detection was developed for simultaneous determination of paclitaxel and its six semisynthesis precursors in needles and hair roots ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1249959
更新日期:2010-10-01 00:00:00
abstract::From stem barks of Isolona guesquiereina three known bisbenzylisoquinolines were isolated and identified as (-)-curine, chondrofoline and isochondodendrine. Structures were established mainly on the basis of comparison of their physical and spectral data with published data for them and their methylated derivatives. C...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2000-8610
更新日期:2000-08-01 00:00:00
abstract::A reinvestigation of the aerial parts of TEUCRIUM SCORDIUM afforded in addition to several known diterpenes five new clerodane derivatives, all closely related to teucrin. The structures and the stereochemistry were elucidated by high resolution (1)H-NMR spectroscopy. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969508
更新日期:1985-08-01 00:00:00
abstract::A microdilution technique was developed for the assessment of in vitro cytotoxicity against KB cells derived from a human epidermoid carcinoma of the nasopharynx. The test was used to determine the cytotoxicity of a series of quassinoids, isolated from Brucea javanica, and which have previously been shown to demonstra...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960020
更新日期:1991-02-01 00:00:00
abstract::From the leaves of DIGITALIS LANATA Ehrh. two new Cardenolides have been found and structurally elucidated as Digoxigenin-3-O-beta- D-digitoxosido-beta- D-digitoxosido-beta- D-xyloside bei TLC and spectroscopic methods. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969697
更新日期:1984-06-01 00:00:00
abstract::Seven coumarins were isolated from the aerial parts of Tordylium apulum; their structures were established by spectroscopic means. All compounds were tested in vitro for their cytotoxicity against two cell line systems. The antiproliferative effects for three of them were studied at the level of the cell cycle in asyn...
journal_title:Planta medica
pub_type: 信件
doi:
更新日期:1998-03-01 00:00:00
abstract::A new BIS-1-oxaquinolizidine alkaloid, 9'- EPI-3 β,3' β-dimethylxestospongin C (2), and three known related analogues have been isolated from the Hainan sponge Neopetrosia exigua. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1250164
更新日期:2011-01-01 00:00:00
abstract::Malaria treatment and control have become increasingly difficult because of the spread of drug-resistant strains of Plasmodium falciparum and Plasmodium vivax. Thus, there is a continuous need to develop new combination therapies such as artemisinin-based combination therapies (ACTs) to contrast the emergence of resis...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-0952-3677
更新日期:2019-08-01 00:00:00
abstract::Emodin, chrysophanol and physcion have been shown to be the major anthraquinone pigments present in the dry roots of RUMEX ABYSINICA. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969640
更新日期:1984-02-01 00:00:00
abstract::Two new lactones, 1 and 2, together with five known compounds, 3-7, were isolated from the marine mangrove fungus Xylaria sp. BL321. Their structures were determined by comprehensive analysis of their MS and NMR spectroscopic data. The absolute configurations of 1 and 2 were established on the basis of electronic circ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-0031-1280347
更新日期:2012-01-01 00:00:00
abstract::Nine isoflavonoids including a new pterocarpene, puemiricarpene, were isolated from the tuberous root of Pueraria mirifica (Leguminosae). The structure of puemiricarpene was determined by spectroscopic means. Estrogenic activity of the isolated isoflavonoids was tested using MCF-7 human breast cancer cells. Moderate a...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2000-8603
更新日期:2000-08-01 00:00:00
abstract::Shoot primordia, which were able to propagate vegetatively with a very high rate and to redifferentiate easily to new plants, were induced from shoot tips of Stevia rebaudiana Bertoni on Gamborg B5 medium containing 6-benzylaminopurine (BAP) and alpha-naphthaleneacetic acid (NAA) under light. The propagation of the sh...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969165
更新日期:1986-08-01 00:00:00
abstract::A novel trinorsesquiterpene (1), three new (2-4), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibit...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1280294
更新日期:2012-01-01 00:00:00
abstract::The fruits of OSTEOPHLOEUM PLATYSPERMUM (Myristicaceae) contain sitosterol, eperu-8(20),13-dien-3alpha,15-diol, glyceryl laurodimyristate, glyceryl 1,3-lauromyristate and five neolignans: dihydroguaiaretic acid, hydroxyotobain, hydroxyoxootobain, guaiacin and otobaphenol. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969620
更新日期:1984-02-01 00:00:00
abstract::The cardiovascular effects of intravenous (i.v.) treatment with the essential oil of Ocimum gratissimum (EOOG) and its main constituent, eugenol (Eug) were investigated in the experimental model of deoxycorticosterone acetate (DOCA-salt)-hypertensive rats. In both conscious DOCA-salt hypertensive rats and their uninep...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-864109
更新日期:2005-04-01 00:00:00
abstract::Immune complex binding to macrophages was enhanced by treatment with an E. kansui extract. Systematic fractionation of the extract led to the characterization of 3-O-(2'E,4'Z-decadienoyl)- and 3-O-(2,3-dimethylbutyryl)-13- O-n-dodecanoyl-13-hydroxyingenol as the active principles. Immune complex binding to macrophages...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-961447
更新日期:1992-06-01 00:00:00
abstract::The inhibitory action of the major constituent of Sebastiania schottiana (Euphorbiaceae), 2-hydroxy-4,6-dimethoxyacetophenone (xanthoxyline) on contractions induced by agonists and electrical stimulation of smooth and cardiac muscle preparations was analysed. Xanthoxyline (30 to 300 microM) inhibited contractions of t...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960878
更新日期:1990-02-01 00:00:00
abstract::An in vitro propagation protocol for rapidly producing Hydrastis canadensis L., Goldenseal, plantlets from disk tissue of young leaves was developed. Leaf explants were inoculated on MS medium supplemented with various concentrations of NAA and TDZ for production of callus. Two-month-old calli were sub-cultured on MS ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2003-37039
更新日期:2003-01-01 00:00:00
abstract::Investigation of Podachaenium eminens afforded nine sesquiterpene lactones (Sls) from which costunolide, 7-hydroxycostunolide, santamarin as well as 3-chlorodehydroleucodin are new for this plant and 3,4-dehydro-4-dehydroxypodachaenin (= 3-costoyloxydehydroleucodin) is found for the first time in nature. All isolated ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2000-8649
更新日期:2000-10-01 00:00:00
abstract::Reduced estrogen levels occurring during menopause in woman are accompanied by a variety of disorders, e. g., hot flushes, depressions, osteoporosis, increase of body weight, and reduced movement drive. In this study we investigated the combined effects of physical activity, estradiol substitution, and a phytoestrogen...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-931579
更新日期:2006-05-01 00:00:00
abstract::Owing to their high content of flavonoids and saponins, plantlets of Avena sativa L. (Poaceae) are likely to possess anti-inflammatory and immunoregulatory properties of value in the treatment of atopic dermatitis (AD). With a view to its potential use in atopic subjects at risk of developing sensitisation to dietary ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1250649
更新日期:2011-06-01 00:00:00
abstract::Blue cohosh, Caulophyllum thalictroides (L.) Michx. is a popular herb, roots and rhizomes of which have been extensively used for women's health. Alkaloids and saponins are considered to be responsible for its pharmacological effects. In this investigation the methanolic extract of the roots of blue cohosh, the alkalo...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0028-1112207
更新日期:2009-03-01 00:00:00
abstract::Treatment of 28-hydroxyolean-12-enes with N-bromosuccinimide (NBS) in acetonitrile at room temperature afforded 12 alpha-bromooleanan-13beta, 28-epoxides in high yield. This reaction resulted in the formation of olean-9 (11), 12-diene-18alpha, 29-epoxides from 29-hydroxy isomers but recovered only starting materials f...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969575
更新日期:1985-12-01 00:00:00
abstract::The roots of HAPLOPAPPUS FREEMONTII afforded in addition to the known 8-oxo-beta-cyperone two further derivatives. The structures were elucidated by highfield (1)H-NMR spectroscopy. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969205
更新日期:1986-10-01 00:00:00
abstract::In natural product research, the isolation of biomarkers or bioactive compounds from complex natural extracts represents an essential step for de novo identification and bioactivity assessment. When pure natural products have to be obtained in milligram quantities, the chromatographic steps are generally labourious an...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1545912
更新日期:2015-11-01 00:00:00
abstract::Cuttings of a clone of A. annua L. (Asteraceae), grown under 16 h photoperiod for 55 days were transferred to six photoperiod treatments in the greenhouse. Under short photoperiods (8, 10, or 12 h), plants flowered after two weeks; plants under long photoperiods (16, 20, or 24 h) remained vegetative until termination ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-958040
更新日期:1995-04-01 00:00:00
abstract::Capillary GC, GC-MS, IR, GC-IR, (1)H- and (13)C-NMR studies of the essential oil from the leaves and cones of ELSHOLTZIA POLYSTACHYA collected from two different locations in India revealed that one oil contained 1,8-cineol (37.3%), the other one perillene (61.2%) as the main constituent. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-961490
更新日期:1992-08-01 00:00:00
abstract::Three new hydroquinone terpenoids with benzogeijerene skeletons, euchroquinols A-C (1- 3), and a new monoterpenylbenzenoid, 9,17-epoxyarnebinol (4), along with five known compounds were isolated from the stem bark of ARNEBIA EUCHROMA. Shikonin (6) exhibited potent anti-HCV activity with a selective index of 43.56, and...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1280266
更新日期:2012-01-01 00:00:00
abstract::This article outlines the development of a simple and specific analytical method for the quantitative determination of eight coumarin constituents from the methanolic extract of the roots of Angelica gigas. The coumarin constituents present in the roots of Angelica gigas were separated using an acetonitrile (0.1 % ace...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-990260
更新日期:2007-11-01 00:00:00
abstract::The inhibitory activity of stilbenes isolated from medicinal plants on cell adhesion molecules on the surface of THP-1 human monocytic cell lines was investigated. Among ten stilbenes tested, four stilbenes displayed a significant inhibitory activity on the expression of both intercellular adhesion molecule-1 (ICAM-1)...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2000-8634
更新日期:2000-10-01 00:00:00