Alkaloids and saponins as cytochrome P450 inhibitors from blue cohosh (Caulophyllum thalictroides) in an in vitro assay.

abstract：:We have examined the immunosuppressive effects of representative ginsenosides (Rb1, Rb2, Re and Rg1) from Panax ginseng C. A. Meyer on CD4+ and CD8+ lymphocyte proliferation. Ginsenosides differentially modulated lymphocyte proliferation induced by concanavalin A (Con A), lipopolysaccharide (LPS), phytohemaglutinin (P...

journal_title：Planta medica

authors： Cho JY,Kim AR,Yoo ES,Baik KU,Park MH

更新日期：2002-06-01 00:00:00

abstract：:Based on the inhibition of Cu(2+)-induced LDL oxidation as marker, the major antioxidants in the fruits of Forsythia suspensa and the stems of Magnolia coco were identified. Of these bioactive tetrahydrofurofuran lignans, pinoresinol, phillygenin, and syringaresinol were more potent than probucol. Sesamin and fargesin...

journal_title：Planta medica

authors： Chen CC,Chen HY,Shiao MS,Lin YL,Kuo YH,Ou JC

更新日期：1999-12-01 00:00:00

abstract：:Acetonylgeraniin, an active principle isolated from the seeds of Euphoria longana Lam. (Sapindaceae), reversed the fall in arterial blood pressure in conscious hypertensive rats (SHRs) with orthostatic hypotension induced by injection of hexamethonium into animals subjected to 90 degrees head-up tilts for 60 seconds. ...

journal_title：Planta medica

authors： Hsu FL,Lu FH,Cheng JT

更新日期：1994-08-01 00:00:00

abstract：:Two new xanthones, caledonixanthone M 1 and caloxanthone L 2, and one new acid, caledonic acid 6 were isolated from the hexane-soluble extract of the stem bark of Calophyllum caledonicum. In the course of this phytochemical study, seven other known compounds - calothwaitesixanthone, calozeyloxanthone, allanxanthone, i...

journal_title：Planta medica

authors： Hay AE,Guilet D,Morel C,Larcher G,Macherel D,Le Ray AM,Litaudon M,Richomme P

更新日期：2003-12-01 00:00:00

abstract：:Three new compounds, 15-acetoxy-12-hydroxy-16-methyl-labda-8(17),13E-diene (1), ent-labda-8(17),13-dien-15,16-olid-19-oic acid methyl ester (2), and 12-hydroxy-labda-8(17),13-dien-15,16-olide (3), together with two known compounds, 19-acetoxy-ent-labda-8(17),13-dien-15,16-olide (4), and 16-acetoxy-12,15-epoxy-15beta-h...

journal_title：Planta medica

authors： Vardamides JC,Sielinou VT,Ndemangou B,Nkengfack AE,Fomum ZT,Poumale HM,Laatsch H

更新日期：2007-05-01 00:00:00

abstract：:Ten flavonoid glycosides were identified in flowers of HETEROTHECA INULOIDES ("Mexican Arnica"). Their structures were established by spectral data (UV, (1)H-NMR, (13)C-NMR, mass) and total acid hydrolysis as kaempferol 3-beta-glucoside, 3-beta-galactoside, 3-beta-rutinoside, 3-beta-robinobioside, quercetin 3-beta-glu...

journal_title：Planta medica

authors： Jerga C,Merfort I,Willuhn G

更新日期：1990-08-01 00:00:00

abstract：:A microdilution technique was developed for the assessment of in vitro cytotoxicity against KB cells derived from a human epidermoid carcinoma of the nasopharynx. The test was used to determine the cytotoxicity of a series of quassinoids, isolated from Brucea javanica, and which have previously been shown to demonstra...

journal_title：Planta medica

authors： Anderson MM,O'Neill MJ,Phillipson JD,Warhurst DC

更新日期：1991-02-01 00:00:00

abstract：:A simultaneous separation of the enantiomers of kawain, dihydrokawain, methysticin, and dihydromethysticin as well as the achiral dienolides yangonin and demethoxyyangonin was carried out on a ChiraSpher NT column. This HPLC method can be used for the investigation of the enantiomeric purity of plant material and herb...

journal_title：Planta medica

authors： Häberlein H,Boonen G,Beck MA

更新日期：1997-02-01 00:00:00

abstract：:The random amplified polymorphic DNA analysis (RAPD) is a method to study genetic variability within and between populations and species on the basis of the amplification of anonymous fragments from genomic DNA templates by means of polymerase chain reaction (PCR). We applied RAPD analysis in order to distinguish medi...

journal_title：Planta medica

authors： Wolf HT,van den Berg T,Czygan FC,Mosandl A,Winckler T,Zündorf I,Dingermann T

更新日期：1999-02-01 00:00:00

abstract：:ECa 233, a standardized extract of Centella asiatica, has been found to exhibit various positive neurological effects and to have a good safety profile. The present study aimed to explore the disposition kinetics of ECa 233, containing madecassoside (53.1 %) and asiaticoside (32.3 %), in rats. The extract was intraven...

journal_title：Planta medica

authors： Anukunwithaya T,Tantisira MH,Tantisira B,Khemawoot P

更新日期：2017-05-01 00:00:00

abstract：:Three new guaiane-type sesquiterpene lactones (1-3), together with nine related sesquiterpenes (4-12), were isolated from the whole extract of Ixeris dentata (Asteraceae). The chemical structures of isolates 1-12 were established by spectroscopic analyses as 3 β,8 β-dihydroxy-guaia-10(14)-en-1 α,4 α,5 α,6 β,7 α,11 βH-...

journal_title：Planta medica

authors： Cha MR,Choi YH,Choi CW,Yoo DS,Kim YS,Choi SU,Kim YH,Ryu SY

更新日期：2011-03-01 00:00:00

abstract：:A new compound kaempferol 3-O-alpha-L-(2"-E-p-coumaroyl)-rhamnopyranoside, as well as the known flavonoids, kaempferol 3-O-beta-D-(6"-E-p-coumaroyl)-glucopyranoside, kaempferol 3-O-alpha-L-(2",3"-di-E-p-coumaroyl)-rhamnopyranoside, and caffeic acid were obtained from the methanolic extract of Platanus orientalis L. bu...

journal_title：Planta medica

authors： Mitrokotsa D,Mitaku S,Demetzos C,Harvala C,Mentis A,Perez S,Kokkinopoulos D

更新日期：1993-12-01 00:00:00

abstract：:Natural products from fungi, especially Ascomycota, play a major role in therapy and drug discovery. Fungal strains originating from marine habitats offer a new avenue for finding unusual molecular skeletons. Here, the marine-derived fungus Epicoccum nigrum (strain 749) was found to produce the azaphilonoid compounds ...

journal_title：Planta medica

authors： Hufendiek P,Stölben SSM,Kehraus S,Merten N,Harms H,Crüsemann M,Arslan I,Gütschow M,Schneider T,König GM

更新日期：2017-08-01 00:00:00

abstract：:Soybean saponin is one of several soybean glycosides. Recently, new soybean saponins which possess the DDMP (2,5-dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one) moiety have been detected. Soyasaponin beta g of these new soybean saponins was shown to inhibit hydrogen peroxide damage to mouse fibroblast cells. Not only t...

journal_title：Planta medica

authors： Yoshikoshi M,Yoshiki Y,Okubo K,Seto J,Sasaki Y

更新日期：1996-06-01 00:00:00

abstract：:Juniperus excelsa fruit essential oil as well as J. oxycedrus, Cedrus libani, and Pinus pinea wood essential oils have been obtained with yields between 2.2 ± 0.3 % to 3.4 ± 0.5 % and analyzed by gas chromatography. Sesquiterpenes mainly characterized C. libani and J. oxycedrus essential oils, while in P. pinea and J....

journal_title：Planta medica

authors： Saab AM,Guerrini A,Sacchetti G,Maietti S,Zeino M,Arend J,Gambari R,Bernardi F,Efferth T

更新日期：2012-12-01 00:00:00

abstract：:Thirty-five flavonoids of seven different types, namely isoflavonoids, chalcones, dihydroflavonols, flavanols, flavanones, flavones, and flavonols were investigated for their ability to inhibit ascorbate-induced microsomal lipid peroxidation and their cytotoxicity. For each activity a structure-activity relationship w...

journal_title：Planta medica

authors： Cos P,Calomme M,Sindambiwe JB,De Bruyne T,Cimanga K,Pieters L,Vlietinck AJ,Vanden Berghe D

更新日期：2001-08-01 00:00:00

abstract：:Activator protein 1 (AP-1) is a transcription factor which plays a critical role in inflammation and carcinogenesis. The present study was conducted to investigate the effect of berberine, an isoquinoline alkaloid present in plants of the genera Berberis and Coptis, on the activity of AP-1 using a reporter gene assay ...

journal_title：Planta medica

authors： Fukuda K,Hibiya Y,Mutoh M,Koshiji M,Akao S,Fujiwara H

更新日期：1999-05-01 00:00:00

abstract：:Gas chromatography-flame ionization detection (GC-FID) was used to assess the chemical profile and quantification of cannabinoids to identify the differences, if existing, in the chemical constituents of in vitro propagated plants (IVP), conventionally grown plants (VP) and indoor grown mother plants (MP-Indoor) of a ...

journal_title：Planta medica

authors： Chandra S,Lata H,Mehmedic Z,Khan IA,ElSohly MA

更新日期：2010-05-01 00:00:00

abstract：:A phytochemical investigation of the whole plants of Cassia occidentalis led to the isolation of two new cycloartane triterpenoids, cycloccidentalic acids A and B (1 and 2), and five new related saponins, cycloccidentalisides I-V (3-7), together with sixteen known compounds. The structures of the isolated compounds we...

journal_title：Planta medica

authors： Li SF,Di YT,Luo RH,Zheng YT,Wang YH,Fang X,Zhang Y,Li L,He HP,Li SL,Hao XJ

更新日期：2012-05-01 00:00:00

abstract：:Ulcerative colitis is a chronic inflammatory condition whose treatment includes aminosalicylates, corticosteroids, and immunomodulators. Medicinal plants seem to be an important alternative treatment for this condition. They have been the subject of a great number of studies in recent years. This study was conducted t...

journal_title：Planta medica

authors： Santana MT,Cercato LM,Oliveira JP,Camargo EA

更新日期：2017-05-01 00:00:00

abstract：:Hyperuricemia is a clinical condition characterized by an elevated level of serum uric acid and is a key risk factor for the development of gout and metabolic disorders. The existing urate-lowering therapies are often impractical for certain patient populations, providing a rationale to explore new agents with improve...

journal_title：Planta medica

authors： Kim JK,Kim WJ,Hyun JM,Lee JS,Kwon JG,Seo C,Song MJ,Choi CW,Hong SS,Park K,Kim P,Sung H,Lee JK,Choi Y

更新日期：2017-11-01 00:00:00

abstract：:Protopanaxatriol and protopanaxadiol exhibit limited oral bioavailability due to the poor solubility and intestinal cytochromes P450-mediated metabolism. This study set out to develop a novel cytochromes P450 inhibitory excipient(s)-based self-microemulsion to encapsulate protopanaxatriol and protopanaxadiol so as to ...

journal_title：Planta medica

authors： Yang F,Zhou J,Liu C,Hu X,Pan R,Chang Q,Liu X,Liao Y

更新日期：2017-03-01 00:00:00

abstract：:Investigation of Podachaenium eminens afforded nine sesquiterpene lactones (Sls) from which costunolide, 7-hydroxycostunolide, santamarin as well as 3-chlorodehydroleucodin are new for this plant and 3,4-dehydro-4-dehydroxypodachaenin (= 3-costoyloxydehydroleucodin) is found for the first time in nature. All isolated ...

journal_title：Planta medica

authors： Castro V,Murillo R,Klaas CA,Meunier C,Mora G,Pahl HL,Merfort I

更新日期：2000-10-01 00:00:00

abstract：:From the fresh rhizomes of Tamus communis five phenanthrenes (1 - 5) were isolated under the guidance of cytotoxic assays in HeLa cells. The compounds were obtained from the highly active CHCl (3) fraction of the MeOH extract by using multistep chromatographic purifications, including VLC, preparative TLC, HPLC and ge...

journal_title：Planta medica

authors： Réthy B,Kovács A,Zupkó I,Forgo P,Vasas A,Falkay G,Hohmann J

更新日期：2006-06-01 00:00:00

abstract：:Natural products research is increasingly turning to marine animals, plants, and microbes as source organisms. Several marine natural products are currently in preclinical and clinical evaluation, others show promising biological activities in in vitro and in vivo assays. Investigations of biological and chemical ecol...

journal_title：Planta medica

authors： König GM,Wright AD

更新日期：1996-06-01 00:00:00

abstract：:The effects of phytoestrogens on the female breast are discussed controversially. On the one hand, epidemiological and experimental data provide evidence that dietary phytoestrogens may prevent the development of breast cancer. On the other hand, in breast cancer cell lines and tumour models isoflavone phytoestrogens ...

journal_title：Planta medica

authors： Hertrampf T,Schmidt S,Seibel J,Laudenbach-Leschowsky U,Degen GH,Diel P

更新日期：2006-03-01 00:00:00

abstract：:Many herbs, and recently their biomass from in vitro cultures, are essential for the treatment of diseases. The aim of this study was to determine the optimal growth of Bacopa monnieri (water hyssop) in an in vitro culture and to examine if extracts of the B. monnieri biomass from the in vitro culture would affect hyd...

journal_title：Planta medica

authors： Łojewski M,Pomierny B,Muszyńska B,Krzyżanowska W,Budziszewska B,Szewczyk A

更新日期：2016-02-01 00:00:00

abstract：:Six new triterpenoid saponins, psychotrianosides A-F (1-6), and two known triterpenoid saponins, psychotrianoside G (7) and ardisianoside D (8), were isolated from Psychotria sp. Their structures were determined mainly by spectroscopic methods. The cytotoxic activities of 1-8 against five human cancer cell lines (MDA-...

journal_title：Planta medica

authors： Zhang CX,Zhang DM,Chen MF,Guan SY,Yao JH,He XX,Lei LF,Zhong Y,Wang ZF,Ye WC

更新日期：2013-07-01 00:00:00

abstract：:DNA sequence analysis of the rDNA internal transcribed spacer 1 (ITS1) and TaqMan real-time polymerase chain reaction were exploited for their applications in the differentiation of the traditional chinese medicinal plants euphorbia humifusa and e. maculata from three related adulterants e. hypericifolia, E. atoto and...

journal_title：Planta medica

authors： Xue HG,Wang H,Li DZ,Xue CY,Wang QZ

更新日期：2008-02-01 00:00:00

abstract：:Infusions of Citrullus colocynthis Schrad. (Cucurbitaceae) fruits are traditionally used as antidiabetic medication in Mediterranean countries, but to our knowledge no studies have been undertaken so far to determine the possible mechanisms involved in the antidiabetic properties of the fruit. The present study was de...

journal_title：Planta medica

authors： Nmila R,Gross R,Rchid H,Roye M,Manteghetti M,Petit P,Tijane M,Ribes G,Sauvaire Y

更新日期：2000-06-01 00:00:00