Anti-allergic properties of the natural PAF antagonist yangambin.

abstract：:Flavonolignan compounds have been isolated from the fruits of SILYBUM MARIANUM subsp. ANATOLICUM and kaempferol 3-sulphate and other flavonoid compounds have been isolated from the aerial parts and were identified. The flavonoid sulphate derivatives are shown to be present in SILYBUM genus for the first time. ...

journal_title：Planta medica

authors： Meriçli AH

更新日期：1988-02-01 00:00:00

abstract：:Scopoletin exhibited an immediate and dose-dependent hypouricemic effect after intraperitoneal administration (50, 100, 200 mg/kg) in hyperuricemic mice induced by potassium oxonate; however, it did not affect the serum uric acid level in normal mice at the tested doses. For exploring the involved mechanisms of action...

journal_title：Planta medica

authors： Ding Z,Dai Y,Wang Z

更新日期：2005-02-01 00:00:00

abstract：:The effect of a lignan-enriched extract of the fruits of Schisandra chinensis (FS) on hepatic glutathione (GSH) status was examined in both control and carbon tetrachloride (CCl4)-treated rats. FS treatment caused a dose-dependent enhancement in hepatic GSH status, as evidenced by significant increases in hepatic GSH ...

journal_title：Planta medica

authors： Ko KM,Ip SP,Poon MK,Wu SS,Che CT,Ng KH,Kong YC

更新日期：1995-04-01 00:00:00

abstract：:PAPAVER SOMNIFERUM L. tissue cultures, issued from various explants (cotyledons, hypocotyls, roots) derived from plantlets belonging to two genotypes, were established on LS solid medium containing growth regulators (NAA, Kin) in various combinations. Hypocotyls and roots were found to be interesting explants to obtai...

journal_title：Planta medica

authors： Laurain-Mattar D,Gillet-Manceau F,Buchon L,Nabha S,Fliniaux MA,Jacquin-Bubreuil A

更新日期：1999-03-01 00:00:00

abstract：:Flavonoids are metabolized in vivo to monocyclic phenolic acids. We investigated whether 18 phenolic acids of the benzoic, phenylacetic, phenylpropanoic or cinnamic series-known or potential metabolites of flavonoids-inhibit reactive oxygen species (ROS) released by human polymorphonuclear neutrophils (PMNs). Chemilum...

journal_title：Planta medica

authors： Limasset B,Ojasoo T,le Doucen C,Doré JC

更新日期：1999-02-01 00:00:00

abstract：:The distribution and level of yew constituents vary with species and tissues. In this study, a rapid and valid method incorporating ultra-fast liquid chromatography (UFLC) with MS and UV detection was developed for simultaneous determination of paclitaxel and its six semisynthesis precursors in needles and hair roots ...

journal_title：Planta medica

authors： Ge GB,Liang SC,Hu Y,Liu XB,Mao YX,Zhang YY,Luan HW,Qiu MH,Yang L

更新日期：2010-10-01 00:00:00

abstract：:Ganoderan B increased the plasma insulin level in normal and glucose-loaded mice but elicited no effect on insulin binding to isolated adipocytes. Administration of ganoderan B elicited significant increases of the activities of hepatic glucokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase, decreased ...

journal_title：Planta medica

authors： Hikino H,Ishiyama M,Suzuki Y,Konno C

更新日期：1989-10-01 00:00:00

abstract：:Because Rhodiola plants are known to have a protective effect on diabetic nephropathy, this study aimed to investigate the inhibitory effect of salidroside, the main active component of Rhodiola plants, on high glucose-induced mesangial cell proliferation and its possible mechanism. Salidroside (1 approximately 100 mi...

journal_title：Planta medica

authors： Yin D,Yao W,Chen S,Hu R,Gao X

更新日期：2009-09-01 00:00:00

abstract：:The gamma-amino butyric acid (GABA) type A (GABA(A)) receptor represents a crucial target for clinical agents in the treatment of anxiety and insomnia. Using the two-microelectrode voltage clamp technique on recombinant α₁β₂γ(2S) GABA (A) receptors, effusol (1) and dehydroeffusol (2) were isolated in a bioactivity-gui...

journal_title：Planta medica

authors： Singhuber J,Baburin I,Khom S,Zehl M,Urban E,Hering S,Kopp B

更新日期：2012-03-01 00:00:00

abstract：:Arctigenin is a phenylpropanoid dibenzylbutyrolactone lignan compound possessing antitumor, anti-inflammatory, anti-influenza, antioxidant, antibacterial, and hypoglycaemic activities. Our previous study demonstrated that arctigenin exerts neuroprotective effects both in vitro and in vivo in a Parkinson's disease mode...

journal_title：Planta medica

authors： Qi Y,Dou DQ,Jiang H,Zhang BB,Qin WY,Kang K,Zhang N,Jia D

更新日期：2017-01-01 00:00:00

abstract：:Ten flavonoid glycosides were identified in flowers of HETEROTHECA INULOIDES ("Mexican Arnica"). Their structures were established by spectral data (UV, (1)H-NMR, (13)C-NMR, mass) and total acid hydrolysis as kaempferol 3-beta-glucoside, 3-beta-galactoside, 3-beta-rutinoside, 3-beta-robinobioside, quercetin 3-beta-glu...

journal_title：Planta medica

authors： Jerga C,Merfort I,Willuhn G

更新日期：1990-08-01 00:00:00

abstract：:We investigated the apoptotic effects of the protopanaxadiol ginsenosides, Rb (1) and Rb (2), and their intestinal bacterial metabolite, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol (M1), and of the protopanaxatriol ginsenoside, Rg (1), and its intestinal bacterial metabolite, 20(S)-protopanaxatriol, in activated ...

journal_title：Planta medica

authors： Park EJ,Zhao YZ,Kim J,Sohn DH

更新日期：2006-10-01 00:00:00

abstract：:The aerial parts of Guarea guidonia afforded three new tirucallane-type triterpenoids: 3,4-seco-tirucalla-4(28),8(9),24(25)-trien-7α,11α-dihydroxy-21,23-epoxy-3,11-olide, named guareolide (1: ), 3,4-seco-tirucalla-4(28),7(8),24(25)-trien-21-hydroxy-21,23-epoxy-3-oic acid, named guareoic acid A (2: ), and 3,4-seco-tiru...

journal_title：Planta medica

authors： Hernandez V,De Leo M,Cotugno R,Braca A,De Tommasi N,Severino L

更新日期：2018-07-01 00:00:00

abstract：:Seven coumarins were isolated from the aerial parts of Tordylium apulum; their structures were established by spectroscopic means. All compounds were tested in vitro for their cytotoxicity against two cell line systems. The antiproliferative effects for three of them were studied at the level of the cell cycle in asyn...

journal_title：Planta medica

authors： Kofinas C,Chinou I,Loukis A,Harvala C,Roussakis C,Maillard M,Hostettmann K

更新日期：1998-03-01 00:00:00

abstract：:Several procyanidin dimers and an epicatechin trimer purified from Douglas fir bark tannins were compared with their monomer components (+)-catechin and (-)-epicatechin for their abilities to inhibit the biochemical effects of the potent tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in mouse epidermis in v...

journal_title：Planta medica

authors： Gali HU,Perchellet EM,Gao XM,Karchesy JJ,Perchellet JP

更新日期：1994-06-01 00:00:00

abstract：:Bioassay-guided fractionation of the roots of Ardisia cornudentata Mez (Myrsinaceae) led to the isolation of three new compounds, 3-methoxy-2-methyl-5-pentylphenol (1), 3-methoxy-2-methyl-5-(1'-ketopentyl)phenol (2), and cornudoside (3), together with twenty-six known compounds. Their structures were elucidated by ana...

journal_title：Planta medica

authors： Chang CP,Chang HS,Peng CF,Lee SJ,Chen IS

更新日期：2011-01-01 00:00:00

abstract：:Seven phenolic derivatives, 2,4-bis(4-hydroxybenzyl)phenol ( 1), bis[4(beta- D-glucopyranosyloxy)-benzyl] ( S)-(-)-2-isopropylmalate ( 2), bis[4-(beta- D-gluco-pyranosyloxy)benzyl] ( S)-(-)-2-sec-butylmalate ( 3), 4-hydroxybenzyaldehyde ( 4), 4,4'-dihydroxydiphenyl-methane ( 5), 4-hydroxybenzyl alcohol ( 6), and 4-(be...

journal_title：Planta medica

authors： Yi-Ming L,Zhuo-Lun Z,Yong-Fu H

更新日期：1993-08-01 00:00:00

abstract：:Five new compounds (1-5), including two limonoids, one triterpenoid, one steroid, and one sesquiterpenoid, along with nine known limonoids (6-14), were isolated from the bark of Melia azedarach. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry. The isolated compounds as ...

journal_title：Planta medica

authors： Yuan CM,Zhang Y,Tang GH,Li Y,He HP,Li SF,Hou L,Li XY,Di YT,Li SL,Hua HM,Hao XJ

更新日期：2013-01-01 00:00:00

abstract：:Evidence is presented for the structure of a new limonoid, amoorinin, from the stem bark of AMOORA ROHITUKA on the basis of spectral and chemical evidences. ...

journal_title：Planta medica

authors： Agnihotri VK,Srivastava SD,Srivastava SK

更新日期：1987-06-01 00:00:00

abstract：:Qianhu, the dried roots of Peucedanum praeruptorum, is a well-known traditional Chinese medicinal herb which was officially listed in the Chinese Pharmacopoeia. Praeruptorin A is the major active constituent of Qianhu. Our previous studies show that praeruptorin effectively transactivated the protein expression and ca...

journal_title：Planta medica

authors： Huang L,Bi HC,Li YH,Zhang JQ,Kuang SY,Zhang L,Wang YT,Huang M

更新日期：2013-11-01 00:00:00

abstract：:Natural compounds have been the first historical source of antithrombotic compounds (heparin, vitamin K antagonists, streptokinase, urokinase); molecules extracted from plants or animals still provide some of the most original and promising approaches for the discovery of new drugs in this class. In this review, we wi...

journal_title：Planta medica

authors： Beretz A,Cazenave JP

更新日期：1991-10-01 00:00:00

abstract：:Bioassay-guided fractionation of the H(2)O extract of the seeds of Psoralea corylifolia furnished one hepatoprotective compound, bakuchiol (1), together with two moderately active compounds, bakuchicin (2) and psoralen (3), on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC(50) values of compo...

journal_title：Planta medica

authors： Cho H,Jun JY,Song EK,Kang KH,Baek HY,Ko YS,Kim YC

更新日期：2001-11-01 00:00:00

abstract：:Treatment of 28-hydroxyolean-12-enes with N-bromosuccinimide (NBS) in acetonitrile at room temperature afforded 12 alpha-bromooleanan-13beta, 28-epoxides in high yield. This reaction resulted in the formation of olean-9 (11), 12-diene-18alpha, 29-epoxides from 29-hydroxy isomers but recovered only starting materials f...

journal_title：Planta medica

authors： Woo WS,Kang SS,Jew SS

更新日期：1985-12-01 00:00:00

abstract：:The aim of this study was to evaluate the effects of 7-epiclusianone (7-epi) on specific virulence attributes of Streptococcus mutans in vitro and on development of dental caries in vivo. 7-Epi was obtained and purified from fruits of Rheedia brasiliensis. We investigated its influence on surface-adsorbed glucosyltran...

journal_title：Planta medica

authors： Branco-de-Almeida LS,Murata RM,Franco EM,dos Santos MH,de Alencar SM,Koo H,Rosalen PL

更新日期：2011-01-01 00:00:00

abstract：:Isoliquiritigenin (4,2',4'-trihydroxychalcone, ISL) is a natural pigment with a simple chalcone structure. In this study, we report the ISL-induced inhibition on the growth of human hepatoma cells (Hep G2) for the first time. The cell growth inhibition achieved by ISL treatment resulted in programmed cell death in a c...

journal_title：Planta medica

authors： Hsu YL,Kuo PL,Lin LT,Lin CC

更新日期：2005-02-01 00:00:00

abstract：:Medicinal herbs are increasingly used in the search for safe and efficient drug candidates for hepatitis C virus infection. In this study, we have investigated the anti-HCV effect of compounds from Mori Cortex Radicis. During a screening for extracts with anti-HCV affinity from medicinal plants (173 species), the meth...

journal_title：Planta medica

authors： Lee HY,Yum JH,Rho YK,Oh SJ,Choi HS,Chang HB,Choi DH,Leem MJ,Choi EJ,Ryu JM,Hwang SB

更新日期：2007-11-01 00:00:00

abstract：:Verbascoside is a phenylethanoid glycoside widely distributed in nature, especially among the order Lamiales, occurring in numerous plants that are constituents of folk medicine preparations. This natural compound, previously isolated by our group from the ethyl acetate extract of Lantana trifolia using the gradient a...

journal_title：Planta medica

authors： Leitão GG,Pinto SC,de Oliveira DR,Timoteo P,Guimarães MG,Cordova WH,Leitão SG

更新日期：2015-11-01 00:00:00

abstract：:In addition to 7-methoxy-2-methyl-3,4,5-trihydroxyanthraquinone (1), physcion (2), macrosporin (3), deoxybostrycin (4), altersolanol B (5) and dactylariol (6), a new hexahydroanthraquinone named pleospdione (7) was isolated from the culture of Pleospora sp . IFB-E006, an endophytic fungus residing in the normal stem o...

journal_title：Planta medica

authors： Ge HM,Song YC,Shan CY,Ye YH,Tan RX

更新日期：2005-11-01 00:00:00

abstract：:Six new pyrrolizidine alkaloids, a new carboxylic acid, a new phenolic and a new oleanane glycoside, together with the known compounds 7,7'-bis-(4-hydroxy-3,5-dimethoxyphenyl)-8,8'-dihydroxymethyltetrahydrofuran 4'-O-beta-D-glucopyranoside, rosmarinic acid, caffeic acid, tormentic acid 28-O-beta- D-glucopyranoside, eu...

journal_title：Planta medica

authors： Braca A,Bader A,Siciliano T,Morelli I,De Tommasi N

更新日期：2003-09-01 00:00:00

abstract：:A systematic structure-activity relationship of 3beta-hydroxy-27- P- E-coumaroyloxyurs-12-en-28-oic acid ( 7), a triterpene ester isolated from UNCARIA RHYNCHOPHYLLA as a phospholipase Cgamma1 inhibitor, was undertaken with a view toward elucidating its chemical mode of action on PLCgamma1. Related derivatives and ana...

journal_title：Planta medica

authors： Lee JS,Yoo H,Suh YG,Jung JK,Kim J

更新日期：2008-10-01 00:00:00