Antimicrobial activity of polyacetylenes from Bellis perennis and their synthetic derivatives.

Abstract:

:The chemical investigation of the essential oils from the aerial organs of Bellis perennis L., the common daisy, showed that polyacetylenes were one of the dominant class of compounds. The major constituents, methyl deca-4,6-diynoate and deca-4,6-diynoic acid, and their structural analogues, deca-4,6-diyne, dimethyl octa-3,5-diyne-1,8-dioate and deca-4,6-diyne-1,10-dioic acid, were synthesised and their antimicrobial activity evaluated. Only deca-4,6-diynoic acid and deca-4,6-diyne-1,10-dioic acid showed antimicrobial activity, being the two compounds mainly effective against Gram-positive and Gram-negative bacteria, respectively. Structure-activity relationships of the tested polyacetylenes are discussed.

journal_name

Planta Med

journal_title

Planta medica

authors

Avato P,Vitali C,Mongelli P,Tava A

doi

10.1055/s-2006-957751

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

503-7

issue

6

eissn

0032-0943

issn

1439-0221

journal_volume

63

pub_type

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