Effect of long-term administration of cordycepin from Cordyceps militaris on testicular function in middle-aged rats.

Abstract:

:This study was carried out to examine the potential beneficial effect of cordycepin on the decline of testicular function induced with age. A total of 30 male Sprague-Dawley rats (twenty-four 12-month-olds and six 2-month-olds) were divided into five groups. The young control (YC) and middle-aged control (MC) groups received vehicle only. Cordycepin-treated groups were administered daily doses of oral cordycepin at 5, 10, and 20 mg/kg body weight for 4 months. As a result, the MC group exhibited epididymal weight loss, decreased sperm motility, and reduced spermatogenesis compared to the young control group. Interestingly, the epididymal weights of middle-aged rats were dose-dependently increased by treatment with cordycepin. Cordycepin also improved calcium levels and decreased urea and nitrogen, uric acid, and creatinine in the blood of middle-aged rats. In addition, cordycepin significantly increased sperm motility and the progressiveness of sperm movement. All cordycepin-treated groups showed well-arranged spermatogonia, densely packed cellular material, and increased numbers of mature spermatozoa in the seminiferous lumen compared to the middle-aged control group. These results indicate that long-term administration of cordycepin can counteract the decline of testicular function in middle-aged rats.

journal_name

Planta Med

journal_title

Planta medica

authors

Sohn SH,Lee SC,Hwang SY,Kim SW,Kim IW,Ye MB,Kim SK

doi

10.1055/s-0032-1315212

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

1620-5

issue

15

eissn

0032-0943

issn

1439-0221

journal_volume

78

pub_type

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