Abstract:
:This study was carried out to examine the potential beneficial effect of cordycepin on the decline of testicular function induced with age. A total of 30 male Sprague-Dawley rats (twenty-four 12-month-olds and six 2-month-olds) were divided into five groups. The young control (YC) and middle-aged control (MC) groups received vehicle only. Cordycepin-treated groups were administered daily doses of oral cordycepin at 5, 10, and 20 mg/kg body weight for 4 months. As a result, the MC group exhibited epididymal weight loss, decreased sperm motility, and reduced spermatogenesis compared to the young control group. Interestingly, the epididymal weights of middle-aged rats were dose-dependently increased by treatment with cordycepin. Cordycepin also improved calcium levels and decreased urea and nitrogen, uric acid, and creatinine in the blood of middle-aged rats. In addition, cordycepin significantly increased sperm motility and the progressiveness of sperm movement. All cordycepin-treated groups showed well-arranged spermatogonia, densely packed cellular material, and increased numbers of mature spermatozoa in the seminiferous lumen compared to the middle-aged control group. These results indicate that long-term administration of cordycepin can counteract the decline of testicular function in middle-aged rats.
journal_name
Planta Medjournal_title
Planta medicaauthors
Sohn SH,Lee SC,Hwang SY,Kim SW,Kim IW,Ye MB,Kim SKdoi
10.1055/s-0032-1315212subject
Has Abstractpub_date
2012-10-01 00:00:00pages
1620-5issue
15eissn
0032-0943issn
1439-0221journal_volume
78pub_type
杂志文章相关文献
PLANTA MEDICA文献大全abstract::Crocin is a pharmacologically active component of Crocus sativus. It is an unusual water-soluble carotenoid responsible for the red color of saffron. In various studies, the anticancer effect of saffron and its constituents has been established. Polyethylene glycolated nanoliposomes with a size range up to 200 nm are ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328363
更新日期:2013-04-01 00:00:00
abstract::From the fresh, undried, and uncrushed leaves of NERIUM OLEANDER a new triterpenoid, kanerocin, has been isolated along with known ursolic and oleanolic acids and its structure established through chemical and spectroscopic methods as 3alpha-hydroxy-urs-18,20-dien-28-oic acid. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-962009
更新日期:1989-06-01 00:00:00
abstract::Eight iridoid glucosides have been isolated from Euphrasia rostkoviana by the combination of open column- and high performance liquid chromatography. The structure of a new compound, named eurostoside, and the identity of the others have been established by chemical transformations and spectral evidence of the compoun...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969960
更新日期:1983-02-01 00:00:00
abstract::The ethanolic extract of Ilex aquifolium L. (Aquifoliaceae) concentration-dependently inhibited leukotriene B4 biosynthesis in isolated bovine PMNL with an IC50 value of about 60 micrograms/ml, whereas the effect on epidermal 12(S)-HETE biosynthesis was much less pronounced. The extract also inhibited the non-enzymati...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957509
更新日期:1998-08-01 00:00:00
abstract::To provide a better understanding of the anti-complement activity of triterpenoids, seven unusual pentacyclic triterpenoids bearing a carboxyl group at C-27 were evaluated for their anticomplement activities against the classical pathway of the complement system. The triterpenoids were isolated from the whole plant of...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2008-1074534
更新日期:2008-06-01 00:00:00
abstract::Geniposide, a main iridoid glucoside component of gardenia fruit, has been shown to possess anti-inflammatory activity. However, its potential use for acute lung injury (ALI) has not yet been studied. The aim of this study was to evaluate the anti-inflammatory properties of geniposide using a mouse ALI model. ALI was ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1298212
更新日期:2012-04-01 00:00:00
abstract::Recently, we showed that intravenous (i.v.) treatment with the essential oil of Mentha x villosa (EOMV) in pentobarbitone-anaesthetised rats decreased blood pressure; the effect occurred independently of the presence of an operational central autonomic drive to the cardiovascular system. This finding suggested that th...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2002-33797
更新日期:2002-08-01 00:00:00
abstract::Six new pyrrolizidine alkaloids, a new carboxylic acid, a new phenolic and a new oleanane glycoside, together with the known compounds 7,7'-bis-(4-hydroxy-3,5-dimethoxyphenyl)-8,8'-dihydroxymethyltetrahydrofuran 4'-O-beta-D-glucopyranoside, rosmarinic acid, caffeic acid, tormentic acid 28-O-beta- D-glucopyranoside, eu...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2003-43202
更新日期:2003-09-01 00:00:00
abstract::Seven phenolic derivatives, 2,4-bis(4-hydroxybenzyl)phenol ( 1), bis[4(beta- D-glucopyranosyloxy)-benzyl] ( S)-(-)-2-isopropylmalate ( 2), bis[4-(beta- D-gluco-pyranosyloxy)benzyl] ( S)-(-)-2-sec-butylmalate ( 3), 4-hydroxybenzyaldehyde ( 4), 4,4'-dihydroxydiphenyl-methane ( 5), 4-hydroxybenzyl alcohol ( 6), and 4-(be...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-959702
更新日期:1993-08-01 00:00:00
abstract::An isolated rabbit heart Langendorff preparation paced electrically was used to evaluate the effects of a highly purified, high molecular weight fraction of oligomeric procyanidines isolated from Vitis vinifera seeds on myocardial reperfusion injury after 40 minutes of low flow (1 ml/min) ischemia. Infusion of the hea...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957956
更新日期:1996-12-01 00:00:00
abstract::A phytochemical investigation of the whole plants of Cassia occidentalis led to the isolation of two new cycloartane triterpenoids, cycloccidentalic acids A and B (1 and 2), and five new related saponins, cycloccidentalisides I-V (3-7), together with sixteen known compounds. The structures of the isolated compounds we...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1298376
更新日期:2012-05-01 00:00:00
abstract::In this study, the significant hepatoprotective effect of dioscin against CCl₄-induced acute liver damage in mice was first discovered, and the effect produced by dioscin at the dose of 100 mg/kg was equal to the action produced by silymarin at the dose of 200 mg/kg. Then, 1-dimension gel electrophoresis was used to s...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1250461
更新日期:2011-03-01 00:00:00
abstract::A novel experimental model of free radical-induced emesis for screening anti-emetic compounds from natural sources was established. 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) dissolved in liposome induced emesis in young chickens, and the emesis was prevented by antioxidants including N-(2-mercaptopropionyl)...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960829
更新日期:1999-08-01 00:00:00
abstract::The flower buds of Lonicera japonica are widely used in Chinese medicine for their anti-inflammatory properties. The reason why L. japonica has potent and significant effects is that it contains various active components, especially chlorogenic acid (CGA). In the present study, we isolated a hydroxycinnamoyl-CoA quina...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1250020
更新日期:2010-11-01 00:00:00
abstract::Menopause is characterized by deep metabolic disturbances, including decreased insulin sensitivity, adiposity, and changes in lipid profiles. Estrogen replacement therapy can partially reverse these changes, and while it is safe in most healthy postmenopausal women, there are still existing concerns regarding an incre...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-0835-6622
更新日期:2019-04-01 00:00:00
abstract::The solid dispersion of a poorly water-soluble Silybum marianum extract (SME) was prepared by a one-step fluid-bed coating technique depositing onto non-pareil pellets. In vitro evaluation indicated that this technique was highly efficient and reproducible producing pellets with acceptable appearance, flowability, fri...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2008-1034294
更新日期:2008-02-01 00:00:00
abstract::In a medium throughput screen of 880 plant and fungal extracts for antiprotozoal activity, a dichloromethane extract of Salvia miltiorrhiza roots was active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum. With HPLC-based activity profiling in combination with on- and off-line spectroscopic metho...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1270933
更新日期:2011-09-01 00:00:00
abstract::Seven flavonol 3- O-glycosides were isolated from the flowers of CALENDULA OFFICINALIS L. Their structures were elucidated as isorhamnetin 3- O-glucoside, rutinoside, neohesperidoside, 2 (G)-rhamnosylrutinoside, quercetin glucoside, neohesperidoside, and 2 (G)-rhamnosylrutinoside by paper and thin layer chromatography...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-961831
更新日期:1989-02-01 00:00:00
abstract::A MeOH extract prepared from culture of an actinomycete Streptomyces sp. HZP-2216E isolated from marine green algae Ulva pertusa was found to significantly inhibit proliferation of human glioma cells. Two different media were applied to culture this marine actinomycete, which produced two new compounds of 23-O-butyryl...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0043-111897
更新日期:2017-12-01 00:00:00
abstract::The composition of the phthalide mixture of the essential oil from roots of Levisticum officinale Koch was investigated. The phthalide mixture was analyzed by combining separation methods - GLC, LSC and TLC - and subsequently using spectroscopic methods - IR, MS and NMR. E- and Z-butylidenephthalide, E- and Z-ligustil...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971448
更新日期:1982-04-01 00:00:00
abstract::From the essential oil of Commiphora guidotti seven sesquiterpene hydrocarbons and a furanosesquiterpenoid, furanodiene, were isolated. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969896
更新日期:1983-06-01 00:00:00
abstract::Rhapontin was purified from a methanol extract from the roots of Rheum undulatum, and rhapontigenin was produced by an enzymatic transformation of rhapontin. Rats were fed a high-cholesterol diet to induce hyperlipidemia, followed by oral treatment with rhapontin or rhapontigenin (1-5 mg/kg/day). Rhapontin and rhapont...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1382999
更新日期:2014-08-01 00:00:00
abstract::Teak ( Tectona grandis L.f., Verbenaceae) sawdust extract inhibited the growth of Aspergillus niger. Centrifugal partition chromatography was used to isolate the active compounds. By (1)H-NMR the active compounds were identified as deoxylapachol and tectoquinone. Two A. niger transgenic strains which show induction of...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-946676
更新日期:2006-08-01 00:00:00
abstract::Fractionation of the aqueous extract of Derris scandens stems extract using tests for eicosanoid inhibition resulted in the isolation of three isoflavonoids, genistein, its 7- O-alpha-rhamno(1-->6)-beta-glucosyl glycoside, a new compound, and two known isoprenyl derivatives 3'-gamma,gamma-dimethylallylweighteone and s...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2004-827147
更新日期:2004-06-01 00:00:00
abstract::Continued examination of the stem bark of Newbouldia laevis afforded three minor phenylethanoid glycosides, designated as newbouldiosides D - F. Their structures were elucidated by spectroscopic methods as β-(3,4-dihydroxyphenyl)ethyl 5-O-syringoyl-β-D-apiofuranosyloxy-(1 → 2)-O-[α-L-rhamnopyranosyl-(1 → 3)]-6-O-E-sin...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-1270-7761
更新日期:2020-11-06 00:00:00
abstract::Aloe barbadensis polysaccharide was partially digested with cellulase and further purified by dialysis, stepwise ethanol precipitation, and size exclusion chromatography. Crude modified Aloe polysaccharide (MAP) activated macrophage cells and stimulated fibroblast growth. Under the same conditions, native Aloe barbade...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2000-11125
更新日期:2000-03-01 00:00:00
abstract::Cuttings of a clone of A. annua L. (Asteraceae), grown under 16 h photoperiod for 55 days were transferred to six photoperiod treatments in the greenhouse. Under short photoperiods (8, 10, or 12 h), plants flowered after two weeks; plants under long photoperiods (16, 20, or 24 h) remained vegetative until termination ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-958040
更新日期:1995-04-01 00:00:00
abstract::A new eudesmanolide sesquiterpene, sivasinolide 6-O-angelate (1), was isolated from the aerial parts of Anthemis ruthenica together with the known compounds chrysanin (2), tanacin (3), 3 beta-hydroxycostunolide (4), centauridin (5), and centaureidin (6). The compounds were obtained by means of bioactivity-guided fract...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-0029-1185942
更新日期:2010-01-01 00:00:00
abstract::In our previous study, we reported the interesting in vitro antiplasmodial activity of some Rwandan plant extracts. This gave rise to the need for these extracts to also be evaluated in vivo and to identify the compounds responsible for their antiplasmodial activity. The aim of our study was, on the one hand, to evalu...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1368322
更新日期:2014-04-01 00:00:00
abstract::Three new tetrahydroprotoberberine N-oxide alkaloids, (-)- cis-corydalmine N-oxide, (-)- trans-corydalmine N-oxide, and (-)- trans-isocorypalmine N-oxide, along with three known benzo[ C]phenanthridine alkaloids, norsanguinarine, dihydrosanguinarine, and oxysanguinarine, six known berberine alkaloids, (-)-tetrahydropa...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-1999-14090
更新日期:1999-10-01 00:00:00