Guineensine, an Acyl-CoA: cholesterol acyltransferase inhibitor, from the fruits of Piper longum.

Abstract:

:Bioactivity-guided fractionations for ACAT inhibitor led to the isolation of guineensine from the CHCl (3) extract of Piper longum. Its structure was identified by spectroscopic means (IR, UV, MS and NMR). Guineensine inhibited ACAT activity in a dose-dependent manner with an IC (50) value of 3.12 micro M.

journal_name

Planta Med

journal_title

Planta medica

authors

Lee SW,Rho MC,Nam JY,Lim EH,Kwon OE,Kim YH,Lee HS,Kim YK

doi

10.1055/s-2004-827193

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

678-9

issue

7

eissn

0032-0943

issn

1439-0221

journal_volume

70

pub_type

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