Guineensine, an Acyl-CoA: cholesterol acyltransferase inhibitor, from the fruits of Piper longum.


:Bioactivity-guided fractionations for ACAT inhibitor led to the isolation of guineensine from the CHCl (3) extract of Piper longum. Its structure was identified by spectroscopic means (IR, UV, MS and NMR). Guineensine inhibited ACAT activity in a dose-dependent manner with an IC (50) value of 3.12 micro M.


Planta Med


Planta medica


Lee SW,Rho MC,Nam JY,Lim EH,Kwon OE,Kim YH,Lee HS,Kim YK




Has Abstract


2004-07-01 00:00:00












  • Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells.

    abstract::Cnidicin (1) and five related coumarins were isolated from the root extract of Angelica koreana (Umbelliferae) as active principles responsible for the inhibitory effect on the degranulation process of cultured mast cells. Cnidicin (1) demonstrated a significant inhibition upon the release of beta-hexosaminidase from ...

    journal_title:Planta medica

    pub_type: 信件


    authors: Ryu SY,Kou NY,Choi HS,Ryu H,Kim TS,Kim KM

    更新日期:2001-03-01 00:00:00

  • [Comparative study of two medicinal Cucurbitaceae].

    abstract::Comparative study of the seeds of two Cucurbitaceae Momordica charantia L. and Herpetospermum caudigerum Wall. shows and important difference for their metabolism concerning particularly aspartic acid. Momordica can produce vicin, while for Herpetospermum, this amino acid would give asparagin. In the other hand, betwe...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Barron D,Kaouadji M,Mariotte AM

    更新日期:1982-11-01 00:00:00

  • Inhibition of platelet aggregation by shikonin derivatives isolated from Arnebia euchroma.

    abstract::Four antiplatelet components were isolated from Arnebia euchroma. They inhibited the aggregation of washed rabbit platelets caused by collagen, arachidonic acid, platelet-activating factor, ADP, or thrombin. The potency of inhibiting collagen-induced platelet aggregation is in the following order: acetylshikonin (IC50...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chang YS,Kuo SC,Weng SH,Jan SC,Ko FN,Teng CM

    更新日期:1993-10-01 00:00:00

  • Characterization of the Anticoagulative Constituents of Angelicae Sinensis Radix and Their Metabolites in Rats by HPLC-DAD-ESI-IT-TOF-MSn.

    abstract::Angelicae Sinensis Radix is commonly used in traditional Chinese medicine. Pharmacological studies show that Angelicae Sinensis Radix has clear anticoagulant activity. Therefore, in this study, the anticoagulant activity of crude Angelicae Sinensis Radix extracts was investigated by measuring the thrombin times of the...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wang L,Huang S,Chen B,Zang XY,Su D,Liang J,Xu F,Liu GX,Shang MY,Cai SQ

    更新日期:2016-03-01 00:00:00

  • Re-introduction of kava (Piper methysticum) to the EU: is there a way forward?

    abstract::Kava (Piper methysticum) is an effective anxiolytic that has been withdrawn from various consumer markets in European countries due to concerns over its hepatotoxicity. It is plausible that the reported hepatotoxicity may be due in part to plant substitution, or an incorrect cultivar, or plant parts being used (such a...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Sarris J,Teschke R,Stough C,Scholey A,Schweitzer I

    更新日期:2011-01-01 00:00:00

  • Protein tyrosine phosphatase 1B (PTP1B)-inhibiting constituents from the leaves of Syzygium polyanthum.

    abstract::A methanol extract of the leaves of Syzygium polyanthum (Wight) Walp. afforded four new acylbenzene derivatives (1-4) together with seven known compounds (5-11). The structures of 1-11 were elucidated by extensive spectroscopic methods and comparison with the literature data. The new compounds 1-3 and a known compound...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Saifudin A,Tanaka K,Kadota S,Tezuka Y

    更新日期:2012-08-01 00:00:00

  • Inhibition of intestinal chloride secretion by proanthocyanidins from Guazuma ulmifolia.

    abstract::The antisecretory activity of Guazuma ulmifolia bark was examined in rabbit distal colon mounted in an Ussing chamber. Chloride secretion was stimulated by cholera toxin and prostaglandin E2 (PGE2). Guazuma ulmifolia extract (GUE) completely inhibited cholera toxin-induced secretion if the extract was added to the muc...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Hör M,Rimpler H,Heinrich M

    更新日期:1995-06-01 00:00:00

  • Microbiological status of commercially available medicinal herbal drugs--a screening study.

    abstract::One hundred and thirty-eight medicinal herbal drugs obtained from different suppliers were examined for microbial contaminants and for the detectability of pathogenic microorganisms. For this purpose, several microbiological standard parameters (total aerobic mesophilic count, enterobacteria, coliforms, aerobic sporef...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Czech E,Kneifel W,Kopp B

    更新日期:2001-04-01 00:00:00

  • Radical scavengers from the entomogenous deuteromycete Beauveria amorpha.

    abstract::The culture medium of Beauveria amorpha Hohn. exhibited strong radical scavenging properties. Activity-directed fractionation assisted by a radical scavenging assay on TLC afforded two active compounds which were identified as 6-methyl-2,4-dihydroxyphenyl 4-O-methyl-beta-D-glucopyranoside (1) and (-)-terredionol (2). ...

    journal_title:Planta medica

    pub_type: 信件


    authors: Hu F,Schmidt K,Stoyanova S,Zengzhi L,Gräfe U,Hamburger M

    更新日期:2002-01-01 00:00:00

  • Die Alkaloide von Uncaria tomentosa und ihre Phagozytose-steigernde Wirkung.

    abstract::From the roots of UNCARIA TOMENTOSA six oxindol alkaloids have been isolated and identified as isopteropodin, pteropodin, mitraphyllin, isomitraphyllin, rynchophyllin and isorynchophyllin. By ion pair chromatography on HPLC a fingerprint analysis has been worked out which allowed to differentiate between various UNICA...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wagner H,Kreutzkamp B,Jurcic K

    更新日期:1985-10-01 00:00:00

  • The extract of Ziziphus jujuba fruit (jujube) induces expression of erythropoietin via hypoxia-inducible factor-1α in cultured Hep3B cells.

    abstract::The fruit of Ziziphus jujuba Mill., known as jujube or Chinese date, is commonly consumed as health supplement or herbal medicine worldwide. To study the beneficial role of jujube in enhancing hematopoietic function, we investigated its roles on the expression of erythropoietin in cultured Hep3B human hepatocellular c...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chen J,Lam CT,Kong AY,Zhang WL,Zhan JY,Bi CW,Chan GK,Lam KY,Yao P,Dong TT,Tsim KW

    更新日期:2014-11-01 00:00:00

  • Simultaneous determination of eight coumarins in Angelica gigas and in various other Angelica species by high performance liquid chromatography and comparative micro-morphology study of Angelica species.

    abstract::This article outlines the development of a simple and specific analytical method for the quantitative determination of eight coumarin constituents from the methanolic extract of the roots of Angelica gigas. The coumarin constituents present in the roots of Angelica gigas were separated using an acetonitrile (0.1 % ace...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Avula B,Joshi VC,Reddy V L N,Choi YW,Khan IA

    更新日期:2007-11-01 00:00:00

  • Antifungal activity from Alpinia galanga and the competition for incorporation of unsaturated fatty acids in cell growth.

    abstract::An antimicrobial diterpene was isolated from Alpinia galanga in the screening for potentiators of phytochemical antibiotic action. The structure was elucidated by spectral data and identified as (E)-8 beta, 17-epoxylabd-12-ene-15, 16-dial (1). Diterpene 1 synergistically enhanced the antifungal activity of quercetin a...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Haraguchi H,Kuwata Y,Inada K,Shingu K,Miyahara K,Nagao M,Yagi A

    更新日期:1996-08-01 00:00:00

  • New triterpenoids from Kadsura heteroclita and their cytotoxic activity.

    abstract::Phytochemical investigations of the stem of Kadsura heteroclita (Roxb) Craib (Schizandraceae) resulted in the isolation and structure elucidation of six new triterpenoidal compounds named heteroclitalactones A-E (1-5) as well as heteroclic acid (6) and heteroclitalactone F (7), which was isolated for the first time fr...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wang W,Liu J,Han J,Xu Z,Liu R,Liu P,Wang W,Ma X,Guan S,Guo D

    更新日期:2006-04-01 00:00:00

  • Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from ginkgo biloba leaves.

    abstract::Ginkgetin, a biflavone isolated from Ginkgo biloba leaves, was previously reported as an inhibitor of group II phospholipase A2. In this study, ginkgetin was evaluated for in vivo antiarthritic and analgesic activities. Ginkgetin (10-20 mg/kg/day) strongly reduced arthritic inflammation in an animal model of rat adjuv...

    journal_title:Planta medica

    pub_type: 信件


    authors: Kim HK,Son KH,Chang HW,Kang SS,Kim HP

    更新日期:1999-06-01 00:00:00

  • Steroidal saponins from Anemarrhena asphodeloides and their effects on superoxide generation.

    abstract::A new steroidal saponin, timosaponin F, along with six known compounds was isolated from the rhizomes of Anemarrhena asphodeloides Bge. On the basis of chemical and spectroscopic evidence, the structure of timosaponin F was elucidated as (5beta, 25 S):-spirostan-3beta,15alpha,23alpha-triol-3-O-beta- glucopyranosyl-(1-...

    journal_title:Planta medica

    pub_type: 信件


    authors: Meng ZY,Zhang JY,Xu SX,Sugahara K

    更新日期:1999-10-01 00:00:00

  • Bioactive β-indoloquinazoline alkaloids from Oricia renieri.

    abstract::Three new β-indoloquinazoline alkaloids, orirenierine A (1), B (2) and C (4), together with eleven known compounds were isolated from the methanol extract of the stems of Oricia renieri. The structures of all compounds were determined by comprehensive analyses of their spectroscopic data and comparison with literature...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wansi JD,Happi EN,Bavoua JL,Devkota KP,Sewald N

    更新日期:2012-01-01 00:00:00

  • Berberine inhibits cell growth and mediates caspase-independent cell death in human pancreatic cancer cells.

    abstract::Pancreatic cancer is one of the most aggressive human malignancies with an increasing incidence worldwide. In addition to the poor survival rates, combinations using gemcitabine as a backbone have failed to show any benefit beyond monotherapy. These facts underscore an urgent need for novel therapeutic options and mot...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Pinto-Garcia L,Efferth T,Torres A,Hoheisel JD,Youns M

    更新日期:2010-08-01 00:00:00

  • Inhibition of butyrylcholinesterase activity by some isoquinoline alkaloids.

    abstract::The inhibition of butyrylcholinesterase activity in human serum by protoberberine, benzophenanthridine and aporphine alkaloids as well as four model compounds has been studied. The mechanism of the inhibition is discussed on the basis of the different types of interaction of these compounds with butyrylcholinesterase ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ulrichová J,Walterová D,Preininger V,Simánek V

    更新日期:1983-07-01 00:00:00

  • Arctigenin Attenuates Learning and Memory Deficits through PI3k/Akt/GSK-3β Pathway Reducing Tau Hyperphosphorylation in Aβ-Induced AD Mice.

    abstract::Arctigenin is a phenylpropanoid dibenzylbutyrolactone lignan compound possessing antitumor, anti-inflammatory, anti-influenza, antioxidant, antibacterial, and hypoglycaemic activities. Our previous study demonstrated that arctigenin exerts neuroprotective effects both in vitro and in vivo in a Parkinson's disease mode...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Qi Y,Dou DQ,Jiang H,Zhang BB,Qin WY,Kang K,Zhang N,Jia D

    更新日期:2017-01-01 00:00:00

  • Protective Effects of α-Boswellic Acids in a Pulmonary Arterial Hypertensive Rat Model.

    abstract::The purpose of this study was to observe the protective effects of α-boswellic acids on hypoxia-induced pulmonary vascular structural remodeling in pulmonary arterial smooth muscle cells in a hypertensive rat model. Pulmonary arterial smooth muscle cells were cultured and then randomly divided into four groups: normox...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Xiao B,Zhang G,Ali Sheikh MS,Shi R

    更新日期:2017-01-01 00:00:00

  • Activity of quinones from teak (Tectona grandis) on fungal cell wall stress.

    abstract::Teak ( Tectona grandis L.f., Verbenaceae) sawdust extract inhibited the growth of Aspergillus niger. Centrifugal partition chromatography was used to isolate the active compounds. By (1)H-NMR the active compounds were identified as deoxylapachol and tectoquinone. Two A. niger transgenic strains which show induction of...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Sumthong P,Damveld RA,Choi YH,Arentshorst M,Ram AF,van den Hondel CA,Verpoorte R

    更新日期:2006-08-01 00:00:00

  • MicroRNAs as New Bioactive Components in Medicinal Plants.

    abstract::Herbal medicine has been used to treat diseases for centuries; however, the biological active components and the mechanistic understanding of actions of plant-derived drugs are permanently discussed. MicroRNAs are a class of small, non-coding RNAs that play crucial roles as regulators of gene expression. In recent yea...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Xie W,Weng A,Melzig MF

    更新日期:2016-08-01 00:00:00

  • Activity on the central nervous system of Himanthalia elongata.

    abstract::We report the effects of a fraction (F1) obtained from Himanthalia elongata on spontaneous locomotor activity, hypermotility, motor coordination, rectal temperature, pentobarbitone-induced hypnosis, pentylenetetrazole-induced convulsions and analgesic activity in the writhing and hot-plate tests. This fraction caused ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Anca JM,Lamela M,Calleja JM

    更新日期:1993-06-01 00:00:00

  • New antihepatotoxic naphtho-pyrone glycosides from the seeds of Cassia tora.

    abstract::Two new naphtho-pyrone glycosides, 9-[(beta-D-glucopyranosyl-(1----6)-O-beta-D-glucopyranosyl)oxy]-10- hydroxy-7-methoxy-3-methyl-1H-naphtho[2,3-c]pyran-1 -one (5) and 6-[(alpha-apiofuranosyl-(1----6)-O-beta-D-glucopyranosyl)oxy]- rubrofusarin (6), together with cassiaside (3) and rubrofusarin-6-beta-gentiobioside (4)...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wong SM,Wong MM,Seligmann O,Wagner H

    更新日期:1989-06-01 00:00:00

  • Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata.

    abstract::The immunomodulatory activity of HN-02, an extract containing a mixture of andrographolides (i.e., andrographolide [88 +/- 5 %] plus 14-deoxyandrographolide and 14-deoxy-11,12-didehydroandrographolide together [12 +/- 3 %]) in a pure powder form was evaluated at 1.0, 1.5, and 2.5 mg/kg on different in vivo and in vitr...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Naik SR,Hule A

    更新日期:2009-06-01 00:00:00

  • Cytotoxicity and immunosuppressive activity of withanolides from Discopodium penninervium.

    abstract::The cytotoxicity and immunosuppressive activities of jaborosalactone-L and three 16 alpha-oxygenated withanolides from the leaves of Discopodium penninervium were studied. Jaborosalactone-L showed cytotoxicity only to the murine macrophage cell line, RAW 264.7, but the 16 alpha-oxygenated withanolides exhibited cytoto...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Habtemariam S

    更新日期:1997-02-01 00:00:00

  • Inhibition of HIV-1 reverse transcriptase and HIV-1 replication by Calophyllum coumarins and xanthones.

    abstract::As part of our continuing study on the Calophyllum species, a number of coumarins, xanthones and chromene acids from different Calophyllum species of Sri Lanka were tested for inhibitory activity against the HIV-1 and its virally-encoded reverse transcriptase (RT). These compounds were found to be inactive in both the...

    journal_title:Planta medica

    pub_type: 信件


    authors: Dharmaratne HR,Tan GT,Marasinghe GP,Pezzuto JM

    更新日期:2002-01-01 00:00:00

  • New lignans and cytotoxic constituents from Wikstroemia lanceolata.

    abstract::Two new lignans, (-)-aptosimon ( 1) and (-)-diasesamin-di-gamma-lactone ( 2), together with twenty-two known compounds, have been isolated from the stems and roots of Wikstroemia lanceolata. The structures of the new compounds were determined through spectral analyses. The proton and carbon assignments of the known se...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lin RW,Tsai IL,Duh CY,Lee KH,Chen IS

    更新日期:2004-03-01 00:00:00

  • Saucernetin-7 and saucernetin-8 isolated from Saururus chinensis inhibit the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells.

    abstract::In the present study, we demonstrate that saucernetin-8 ( 1) and saucernetin-7 ( 2), isolated from the underground parts of Saururus chinensis (Saururaceae), exerted potent inhibitory effects on LPS-induced nitric oxide (NO) and prostaglandin E (2) (PGE (2)) production in RAW 264.7 cells. Both compounds 1 and 2, known...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Park HJ,Kim RG,Seo BR,Ha J,Ahn BT,Bok SH,Lee YS,Kim HJ,Lee KT

    更新日期:2003-10-01 00:00:00