Abstract:
:We aimed to find antiallergic agents from natural sources using mast cells activated during allergic reaction. We screened over 2000 plants for blockade of histamine release and identified two of them, S. baicalenesis and P. edulis. Bioassay-guided fractionation led to two main constituent flavonoids, baicalin from S. baicalenesis roots and isoorientin from P. edulis leaves. Based on these two compounds, two standardized extracts (SSBE and SPEE) and a combined standardized herb composition (SHC) were developed. SSBE, SPEE, and SHC remarkably inhibited histamine and leukotriene release from mast cells activated by anti-OVA/OVA binding, and SHC showed a stronger inhibition than either extract alone. SHC also showed greater inhibition potency than either aspirin or cromolyn, which are known antiallergic agents. Our results suggest that SHC reduce degranulation during mast cell activation and could be a promising candidate for the treatment of immune/allergic diseases related to mast cells.
journal_name
Planta Medjournal_title
Planta medicaauthors
Kim DS,Son EJ,Kim M,Heo YM,Nam JB,Ro JY,Woo SSdoi
10.1055/s-0029-1240649subject
Has Abstractpub_date
2010-05-01 00:00:00pages
678-82issue
7eissn
0032-0943issn
1439-0221journal_volume
76pub_type
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