Endophytic fungal metabolite fumigaclavine C causes relaxation of isolated rat aortic rings.

abstract：:Kava (Piper methysticum) is an effective anxiolytic that has been withdrawn from various consumer markets in European countries due to concerns over its hepatotoxicity. It is plausible that the reported hepatotoxicity may be due in part to plant substitution, or an incorrect cultivar, or plant parts being used (such a...

journal_title：Planta medica

authors： Sarris J,Teschke R,Stough C,Scholey A,Schweitzer I

更新日期：2011-01-01 00:00:00

abstract：:The effects of phytoestrogens on the female breast are discussed controversially. On the one hand, epidemiological and experimental data provide evidence that dietary phytoestrogens may prevent the development of breast cancer. On the other hand, in breast cancer cell lines and tumour models isoflavone phytoestrogens ...

journal_title：Planta medica

authors： Hertrampf T,Schmidt S,Seibel J,Laudenbach-Leschowsky U,Degen GH,Diel P

更新日期：2006-03-01 00:00:00

abstract：:In a medium throughput screen of 880 plant and fungal extracts for antiprotozoal activity, a dichloromethane extract of Salvia miltiorrhiza roots was active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum. With HPLC-based activity profiling in combination with on- and off-line spectroscopic metho...

journal_title：Planta medica

authors： Slusarczyk S,Zimmermann S,Kaiser M,Matkowski A,Hamburger M,Adams M

更新日期：2011-09-01 00:00:00

abstract：:Barbaloin levels in the exudates from the leaves of 68 species of ALOE in the Kew collection have been determined by light absorption at 375 nm following separation by HPLC. The exudates from most species contained between 10-20% although a few concentrations of around 30% were found. The level in the leaf was usually...

journal_title：Planta medica

authors： Groom QJ,Reynolds T

更新日期：1987-08-01 00:00:00

abstract：:In this work we studied the effect of alpha-asarone, a hypolipidemic active principle of Guatteria gaumeri Greenman, on hepatic lipid metabolism using adult rat hepatocytes cultured on a feeder layer of 3T3 cells. These cultures synthesize and secrete for at least two weeks various lipids from [14C]-acetic and [14C]-o...

journal_title：Planta medica

authors： Hernández A,López ML,Chamorro G,Mendoza-Figueroa T

更新日期：1993-04-01 00:00:00

abstract：:The therapeutic goal in liver fibrosis is the reversal of fibrosis and the selective clearance of activated hepatic stellate cells (HSCs) by inducing apoptosis. Over the past several years, we have screened for natural products that mediate apoptosis in activated HSCs. Among the candidate compounds, honokiol, isolated...

journal_title：Planta medica

authors： Park EJ,Zhao YZ,Kim YH,Lee BH,Sohn DH

更新日期：2005-01-01 00:00:00

abstract：:Cell Suspension cultures of THAMNOSMA MONTANA were grown in Gamborg B5 medium which was best suited for acridone alkaloid formation. From the lyophilized cell material nine acridones and three acridone-monoglucosides have been isolated which were found for the first time in the genus THAMNOSMA. Moreover, N-methylacrid...

journal_title：Planta medica

authors： Baumert A,Maier W,Matern U,Schmidt J,Schumann B,Gröger D

更新日期：1994-04-01 00:00:00

abstract：:The antiinflammatory activity of borjatriol (a diterpenoid isolated from SIDERITIS MUGRONENSIS Borja) was tested using the cotton pellet-granuloma assay. The compound inhibited the granuloma weight and the serum lysozyme activity in a dose-dependently way. The determination of this enzyme has allowed us to distinguish...

journal_title：Planta medica

authors： Villar A,Salom R,Alcaraz MJ

更新日期：1984-02-01 00:00:00

abstract：:The anti-inflammatory effects of boldine and reticuline isolated from Litsea cubeba were evaluated by using xylene-induced ear edema and carrageenan-induced paw edema in mice and rats. Our results demonstrated that intragastric administration with boldine and reticuline significantly mitigated ear weight in mice and d...

journal_title：Planta medica

authors： Yang X,Gao X,Cao Y,Guo Q,Li S,Zhu Z,Zhao Y,Tu P,Chai X

更新日期：2018-01-01 00:00:00

abstract：:Human vascular endothelial cells (HUVECs) were exposed to CoCl2 as an in vitro model of hypoxia. Expression of VCAM-1 (vascular cell adhesion molecule), reduction of PECAM-1 (platelet endothelial cell adhesion molecule) and cytoskeletal changes without alterations in cell viability were observed. HUVECs were also expo...

journal_title：Planta medica

authors： Montopoli M,Froldi G,Comelli MC,Prosdocimi M,Caparrotta L

更新日期：2007-03-01 00:00:00

abstract：:Cannabis (Cannabis sativa L.) is an annual herbaceous plant that belongs to the family Cannabaceae. Trans-Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two major phytocannabinoids accounting for over 40% of the cannabis plant extracts, depending on the variety. At the University of Mississippi, differ...

journal_title：Planta medica

authors： Ibrahim EA,Gul W,Gul SW,Stamper BJ,Hadad GM,Abdel Salam RA,Ibrahim AK,Ahmed SA,Chandra S,Lata H,Radwan MM,ElSohly MA

更新日期：2018-03-01 00:00:00

abstract：:The effects of four fractions, a hexane fraction, an ethyl acetate fraction, an N-butanol fraction and a water fraction, from a water extract of Herba Visci were investigated to find the fraction, in IN VITRO experiments, with the greatest ability to inhibit the formation of osteoclast-like multinucleated cells from m...

journal_title：Planta medica

authors： Yin J,Han N,Xu X,Liu Z,Zhang B,Kadota S

更新日期：2008-02-01 00:00:00

abstract：:Immune complex binding to macrophages was enhanced by treatment with an E. kansui extract. Systematic fractionation of the extract led to the characterization of 3-O-(2'E,4'Z-decadienoyl)- and 3-O-(2,3-dimethylbutyryl)-13- O-n-dodecanoyl-13-hydroxyingenol as the active principles. Immune complex binding to macrophages...

journal_title：Planta medica

authors： Matsumoto T,Cyong JC,Yamada H

更新日期：1992-06-01 00:00:00

abstract：:We report the effects of a fraction (F1) obtained from Himanthalia elongata on spontaneous locomotor activity, hypermotility, motor coordination, rectal temperature, pentobarbitone-induced hypnosis, pentylenetetrazole-induced convulsions and analgesic activity in the writhing and hot-plate tests. This fraction caused ...

journal_title：Planta medica

authors： Anca JM,Lamela M,Calleja JM

更新日期：1993-06-01 00:00:00

abstract：:From the rhizome of Zingiber officinale L. (Zingiberaceae), four shogaols that protect IMR32 human neuroblastoma and normal human umbilical vein endothelial cells from beta-amyloid(25 - 35) insult at EC50 = 4.5 - 81 microM were isolated. The efficacy of cell protection from beta-amyloid(25 - 35) insult by these shogao...

journal_title：Planta medica

authors： Kim DS,Kim DS,Oppel MN

更新日期：2002-04-01 00:00:00

abstract：:Three new compounds, 15-acetoxy-12-hydroxy-16-methyl-labda-8(17),13E-diene (1), ent-labda-8(17),13-dien-15,16-olid-19-oic acid methyl ester (2), and 12-hydroxy-labda-8(17),13-dien-15,16-olide (3), together with two known compounds, 19-acetoxy-ent-labda-8(17),13-dien-15,16-olide (4), and 16-acetoxy-12,15-epoxy-15beta-h...

journal_title：Planta medica

authors： Vardamides JC,Sielinou VT,Ndemangou B,Nkengfack AE,Fomum ZT,Poumale HM,Laatsch H

更新日期：2007-05-01 00:00:00

abstract：:(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethylperhydro-1,4-oxazine-2,5-dione (1) was isolated from the fruiting bodies of Isaria japonica as an apoptosis-inducing agent. The complete structural assignment of the compound was accomplished on the basis of spectroscopic methods and chemical transformations. Compound 1...

journal_title：Planta medica

authors： Oh H,Kim T,Oh GS,Pae HO,Hong KH,Chai KY,Kwon TO,Chung HT,Lee HS

更新日期：2002-04-01 00:00:00

abstract：:In addition to 7-methoxy-2-methyl-3,4,5-trihydroxyanthraquinone (1), physcion (2), macrosporin (3), deoxybostrycin (4), altersolanol B (5) and dactylariol (6), a new hexahydroanthraquinone named pleospdione (7) was isolated from the culture of Pleospora sp . IFB-E006, an endophytic fungus residing in the normal stem o...

journal_title：Planta medica

authors： Ge HM,Song YC,Shan CY,Ye YH,Tan RX

更新日期：2005-11-01 00:00:00

abstract：:Hot water extract (ALR-0) of rhizomes of Atractylodes lanceo DC. was fractionated into MeOH-soluble fraction (ALR-1), supernatant fraction of EtOH precipitation (ALR-3 + 4), and crude polysaccharide fraction (ALR-5). Among these fractions, only ALR-5 showed potent stimulating activity for proliferation of bone marrow ...

journal_title：Planta medica

authors： Yu KW,Kiyohara H,Matsumoto T,Yang HC,Yamada H

更新日期：1998-12-01 00:00:00

abstract：:Three new steroidal saponins were isolated from the fruits of Tribulus terrestris, and their structures were elucidated as (25R,S)-5 alpha-spirostane-12-one-3 beta-ol-3-O-beta-xylopyranosyl(1-->2)- [beta-xylopyranosyl(1-->3)]-beta-glucopyranosyl(1-->4)-[alpha-rhamno- pyranosyl(1-->2)]-beta-galactopyranoside; 26-O-beta...

journal_title：Planta medica

authors： Cai L,Wu Y,Zhang J,Pei F,Xu Y,Xie S,Xu D

更新日期：2001-03-01 00:00:00

abstract：:The crude extract (IPA) of the plant Ipomoea pes-caprae (L.) R. Br. showed an inhibitory effect on prostaglandin synthesis in vitro. Bioassay-guided separation of the extract led to the isolation of four active compounds: 2-hydroxy-4,4,7-trimethyl-1(4H)-naphthalenone (1), (-)-mellein (2), eugenol (3), and 4-vinyl-guai...

journal_title：Planta medica

authors： Pongprayoon U,Baeckström P,Jacobsson U,Lindström M,Bohlin L

更新日期：1991-12-01 00:00:00

abstract：:The aerial parts of JUNGIA SETERIANA afforded in addition to known compounds two pairs of isomeric C (17)-acetylenes which differ in the number of triple bonds and in the configuration of the 9,10-double bond. The structures and configurations followed from the UV and the (1)H-NMR spectra, especially from those of the...

journal_title：Planta medica

authors： Bohlmann F,Zdero C,King RM,Robinson H

更新日期：1984-04-01 00:00:00

abstract：:A new isoquinoline alkaloid (6), along with nine known ones (1-5, 7-10), was isolated from the plateau plant Corydalis hendersonii, which is used as a traditional Tibetan medicine. The structure of the new compound was elucidated as 9-methyldecumbenine C by spectroscopic evidence. ...

journal_title：Planta medica

authors： Fu Y,Zhou Y,Liao X,Bai B,Peng S,Ding L

更新日期：2009-04-01 00:00:00

abstract：:Natural products research is increasingly turning to marine animals, plants, and microbes as source organisms. Several marine natural products are currently in preclinical and clinical evaluation, others show promising biological activities in in vitro and in vivo assays. Investigations of biological and chemical ecol...

journal_title：Planta medica

authors： König GM,Wright AD

更新日期：1996-06-01 00:00:00

abstract：:Astilbin, a flavonoid compound, was isolated from the rhizome of Smilax glabra Roxb. This study was conducted to investigate the efficacy of astilbin on experimental diabetic nephropathy (DN) in vivo and in vitro and its possible mechanisms. Astilbin was added in high glucose stimulated HK-2 cells, streptozotocin-indu...

journal_title：Planta medica

authors： Li GS,Jiang WL,Yue XD,Qu GW,Tian JW,Wu J,Fu FH

更新日期：2009-11-01 00:00:00

abstract：:Rhapontin was purified from a methanol extract from the roots of Rheum undulatum, and rhapontigenin was produced by an enzymatic transformation of rhapontin. Rats were fed a high-cholesterol diet to induce hyperlipidemia, followed by oral treatment with rhapontin or rhapontigenin (1-5 mg/kg/day). Rhapontin and rhapont...

journal_title：Planta medica

authors： Jo SP,Kim JK,Lim YH

更新日期：2014-08-01 00:00:00

abstract：:ECa 233, a standardized extract of Centella asiatica, has been found to exhibit various positive neurological effects and to have a good safety profile. The present study aimed to explore the disposition kinetics of ECa 233, containing madecassoside (53.1 %) and asiaticoside (32.3 %), in rats. The extract was intraven...

journal_title：Planta medica

authors： Anukunwithaya T,Tantisira MH,Tantisira B,Khemawoot P

更新日期：2017-05-01 00:00:00

abstract：:Airway remodeling is an important characteristic of asthma, linking inflammation with airway hyperresponsiveness. Baicalin, a major active component, was isolated from Radix Scutellariae. Many studies show that baicalin has anti-inflammatory, anti-bacterial, and anti-allergic effects. Here we investigate the influence...

journal_title：Planta medica

authors： Sun J,Li L,Wu J,Liu B,Gong W,Lv Y,Luo Q,Duan X,Dong J

更新日期：2013-03-01 00:00:00

abstract：:Ulcerative colitis is a chronic inflammatory condition whose treatment includes aminosalicylates, corticosteroids, and immunomodulators. Medicinal plants seem to be an important alternative treatment for this condition. They have been the subject of a great number of studies in recent years. This study was conducted t...

journal_title：Planta medica

authors： Santana MT,Cercato LM,Oliveira JP,Camargo EA

更新日期：2017-05-01 00:00:00

abstract：:This study aimed to elucidate the mechanisms of nuciferine (a main aporphine alkaloid of lotus leaf extract), which can induce relaxation in contracted tracheal rings. Under Ca2+-free and 2 mM Ca2+ conditions, we found that nuciferine had no effect on the resting muscle tone of tracheal rings. In contrast, nuciferine ...

journal_title：Planta medica

authors： Yang X,Yu MF,Lei J,Peng YB,Zhao P,Xue L,Chen W,Ma LQ,Liu QH,Shen J

更新日期：2018-01-01 00:00:00