Smooth muscle relaxing activity of gentiopicroside isolated from Gentiana spathacea.


:Bioassay directed fractionation of the (1:1) chloroform-methanol extract of Gentiana spathacea H.B.K (Gentianaceae) led to the isolation of gentiopicroside (gentiopricrin) (1), the major spasmolytic component of the plant. Gentiopicroside inhibited, in a concentration-dependent manner, the spontaneous contractions of isolated guinea pig ileum. Contractions induced by histamine, acetylcholine, BaCl2 and KCl on the ileum were also significantly blocked by this monoterpene glucoside, which suggests that this compound might be interfering with calcium influx into the smooth muscle cells.


Planta Med


Planta medica


Rojas A,Bah M,Rojas JI,Gutiérrez DM




Has Abstract


2000-12-01 00:00:00












  • Reversal caused by n-butylidenephthalide from the deficits of inhibitory avoidance performance in rats.

    abstract::The present study was designed to investigate the mechanism of action of n-butylidenephthalide on the deficits of inhibitory avoidance performance induced by drugs in rats with piracetam as a positive control. n-Butylidenephthalide attenuated the scopolamine-induced and mecamylamine-induced acquisition impairment, and...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Hsieh MT,Wu CR,Lin LW,Hsieh CC,Tsai CH

    更新日期:2001-02-01 00:00:00

  • Trypanocidal activity of a new diterpene from Casearia sylvestris var. lingua.

    abstract::Bioassay-guided fractionation of the hexanic root bark extract of Casearia sylvestris var. lingua led to the isolation of a new clerodane diterpene, whose structure was elucidated as rel-(2 S,5 R,6 R,8 S,9 S,10 R,18 S,19 R)-19-acetoxy-18,19-epoxy-6-hydroxy-18-butanoyloxy-2-(2-methylbutanoyloxy)cleroda-3,13(16), 14-tri...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Espindola LS,Vasconcelos Júnior JR,de Mesquita ML,Marquié P,de Paula JE,Mambu L,Santana JM

    更新日期:2004-11-01 00:00:00

  • Bioactive Isocedrenes from Perezia multiflora.

    abstract::Four isocedrenes (1:  - 4: ), including one new compound (2: ), were isolated from an ethanolic extract of the aerial parts of Perezia multiflora by bioactivity-guided fractionation. For compounds 1: and 3: , a revised stereochemical assignment is proposed based on molecular modeling studies using DFT-NMR calculations...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Bourgeade-Delmas S,André-Barrès C,Lucas J,Trinel M,Castillo Pareja D,Jullian V

    更新日期:2020-11-23 00:00:00

  • Quantitative determination of ophiopogonin d by liquid chromatography/electrospray ionization mass spectrometry and its pharmacokinetics in rat.

    abstract::A sensitive and rapid liquid chromatography-mass spectrometric method for the determination of ophiopogonin D in rat plasma was developed and validated. Chromatographic separation was performed on a C (18) column using a step gradient program with the mobile phase of 0.5 mmol/L ammonium chloride solution and acetonitr...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Xia CH,Sun JG,Hao HP,Wang GJ,Yan B,Gu SH,Zheng CN,Shang LL,Roberts MS

    更新日期:2008-12-01 00:00:00

  • Inhibitory activity of phenolic glycosides from the fruits of Idesia polycarpa on lipopolysaccharide-induced nitric oxide production in BV2 microglia.

    abstract::Two new phenolic glycosides characterized as idesin salicylate (1) and 2-hydroxyphenol-1-O-beta-D-glucopyranosyl-(6-->1)- alpha-L-rhamnopyranoside (2) were isolated with four known compounds, idescarpin (3), idesin (4), 1-hydroxy-6-oxocyclohex-2-enecarboxylic acid methyl ester (5) and salirepin (6), from the fruits of...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kim SH,Jang YP,Sung SH,Kim YC

    更新日期:2007-02-01 00:00:00

  • Vermistatin derivatives with α-glucosidase inhibitory activity from the mangrove endophytic fungus Penicillium sp. HN29-3B1.

    abstract::Three new vermistatin derivatives, 6-demethylpenisimplicissin (1), 5'-hydroxypenisimplicissin (2), and 2''-epihydroxydihydrovermistatin (3), along with five known vermistatin analogues, methoxyvermistatin (4), vermistatin (5), 6-demethylvermistatin (6), hydroxyvermistatin (7), and penisimplicissin (8), were isolated f...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Liu Y,Xia G,Li H,Ma L,Ding B,Lu Y,He L,Xia X,She Z

    更新日期:2014-07-01 00:00:00

  • Salvia plebeia Extract Inhibits Xanthine Oxidase Activity In Vitro and Reduces Serum Uric Acid in an Animal Model of Hyperuricemia.

    abstract::Hyperuricemia is a clinical condition characterized by an elevated level of serum uric acid and is a key risk factor for the development of gout and metabolic disorders. The existing urate-lowering therapies are often impractical for certain patient populations, providing a rationale to explore new agents with improve...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kim JK,Kim WJ,Hyun JM,Lee JS,Kwon JG,Seo C,Song MJ,Choi CW,Hong SS,Park K,Kim P,Sung H,Lee JK,Choi Y

    更新日期:2017-11-01 00:00:00

  • Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice.

    abstract::Compelling evidence suggests that infiltrating CD4+ type I helper T (Th1) cells in the pancreatic islets play a pivotal role in the progression of diabetes in non-obese diabetic (NOD) mice. We demonstrate in the present report that a butanol fraction of B. pilosa suppressed the development of diabetes, helped maintain...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chang SL,Chang CL,Chiang YM,Hsieh RH,Tzeng CR,Wu TK,Sytwu HK,Shyur LF,Yang WC

    更新日期:2004-11-01 00:00:00

  • Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection - an update (1998 - 2007).

    abstract::The high number of citations of the previous review on anti-HIV compounds from plants published in 1998 in Planta Medica indicates the importance of natural products research in the battle against HIV. Therefore, we have decided to write an update of our previous review paper, this time covering the time span 1998 - 2...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Cos P,Maes L,Vlietinck A,Pieters L

    更新日期:2008-09-01 00:00:00

  • Inhibition of HIV-1 reverse transcriptase and HIV-1 replication by Calophyllum coumarins and xanthones.

    abstract::As part of our continuing study on the Calophyllum species, a number of coumarins, xanthones and chromene acids from different Calophyllum species of Sri Lanka were tested for inhibitory activity against the HIV-1 and its virally-encoded reverse transcriptase (RT). These compounds were found to be inactive in both the...

    journal_title:Planta medica

    pub_type: 信件


    authors: Dharmaratne HR,Tan GT,Marasinghe GP,Pezzuto JM

    更新日期:2002-01-01 00:00:00

  • A new cytotoxic trichothecene macrolide from the endophyte Myrothecium roridum.

    abstract::A new cytotoxic roridin-type trichothecene macrolide named roritoxin E(1) was characterized from the solid culture of Myrothecium roridum IFB-E091 (residing originally inside Artemisia annua root), together with the known compounds lumichrome (2), (22 E,24 S)-cerevisterol (3), and (22 E,24 R)-6 beta-methoxy-ergosta-7,...

    journal_title:Planta medica

    pub_type: 信件


    authors: Shen L,Wang JS,Shen HJ,Song YC,Tan RX

    更新日期:2010-07-01 00:00:00

  • Antimicrobial activity of polyacetylenes from Bellis perennis and their synthetic derivatives.

    abstract::The chemical investigation of the essential oils from the aerial organs of Bellis perennis L., the common daisy, showed that polyacetylenes were one of the dominant class of compounds. The major constituents, methyl deca-4,6-diynoate and deca-4,6-diynoic acid, and their structural analogues, deca-4,6-diyne, dimethyl o...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Avato P,Vitali C,Mongelli P,Tava A

    更新日期:1997-12-01 00:00:00

  • Allele-specific primers for diagnostic PCR authentication of Dendrobium officinale.

    abstract::Based on rDNA ITS sequences of D. officinale and the other 37 species of Dendrobium, a pair of allele-specific diagnostic primers, TP-JB01S and TP-JB01X, were designed to authenticate D. officinale from the other species. Before the diagnostic PCR, the primer pair, P1 and P2, for amplifying the whole ITS region was us...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ding X,Wang Z,Zhou K,Xu L,Xu H,Wang Y

    更新日期:2003-06-01 00:00:00

  • Procyanidines from Vitis vinifera seeds protect rabbit heart from ischemia/reperfusion injury: antioxidant intervention and/or iron and copper sequestering ability.

    abstract::An isolated rabbit heart Langendorff preparation paced electrically was used to evaluate the effects of a highly purified, high molecular weight fraction of oligomeric procyanidines isolated from Vitis vinifera seeds on myocardial reperfusion injury after 40 minutes of low flow (1 ml/min) ischemia. Infusion of the hea...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Maffei Facinó R,Carini M,Aldini G,Berti F,Rossoni G,Bombardelli E,Morazzoni P

    更新日期:1996-12-01 00:00:00

  • [Barbatoside, a new Iridoid glucoside from Penstemon barbatus].

    abstract::From leaves of Penstemon barbatus Nutt. a new iridoid glucoside has been isolated. The structure was established mainly by spectroscopic methods ( (1)H-NMR, (13)C-NMR, IR, MS). ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Junior P

    更新日期:1982-06-01 00:00:00

  • Three new alkaloids from Galanthus nivalis and Galanthus elwesii.

    abstract::Phytochemical studies on Galanthus species resulted in the isolation of three new compounds: 3,3'-O-(3',3''-dihydroxybutanoyl)hamayne and 11,3'-O-(3',3''-dihydroxybutanoyl)hamayne from G. nivalis and 2-O-(3'-hydroxybutanoyl)lycorine from G. elwesii. Additionally, 3,11-O-(3',3''-dihydroxybutanoyl)hamayne, 3,11,3'-O-(3'...

    journal_title:Planta medica

    pub_type: 信件


    authors: Berkov S,Cuadrado M,Osorio E,Viladomat F,Codina C,Bastida J

    更新日期:2009-10-01 00:00:00

  • The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions.

    abstract::A plant mixture containing extracts of Nigella sativa possesses blood glucose lowering effects, but the direct antidiabetic effect of Nigella sativa is not yet established. Therefore, the effect of Nigella sativa oil (NSO) on blood glucose concentrations was studied in streptozotocin diabetic rats. In addition, the ef...

    journal_title:Planta medica

    pub_type: 信件


    authors: El-Dakhakhny M,Mady N,Lembert N,Ammon HP

    更新日期:2002-05-01 00:00:00

  • Immunoassays for the quantitative determination of colchicine.

    abstract::A radioimmunoassay as well as an enzyme immunoassay for the quantitation of fmol amounts of the alkaloid colchicine have been developed. The antiserum used for both assays was raised against a conjugate of colchicoside-bovine serum albumin. The crude serum was satisfactory for the performance of the radioimmunoassay. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Poulev A,Deus-Neumann B,Bombardelli E,Zenk MH

    更新日期:1994-02-01 00:00:00

  • Molecular Identification Based on Chloroplast Sequences and Anti-complementary Activity Comparison of Juniperus Samples from the Qinghai-Tibet Plateau.

    abstract::Juniperus (Cupressaceae, Pinales) plants are widely distributed in the Qinghai-Tibet Plateau of China. The leaves and twigs of at least 8 Juniperus species (J. pingii, J. pingii var. wilsonii, J. squamata, J. recurva var. coxii, J. saltuaria, J. indica, J. tibetica and J. convallium var. microsperma) have been used as...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yang YT,De J,Fu ZL,Wang XL,Chen DF,Xie H,Lu Y

    更新日期:2020-11-01 00:00:00

  • HPTLC method for the estimation of alkaloids of Cinchona officinalis stem bark and its marketed formulations.

    abstract::We report a sensitive method for the estimation of quinine (Qn), cinchonine (Cn), and cinchonidine (Cnd) and a new method based on fluorescence enhancement and detection and quantification of quinidine (Qnd) from Cinchona stem bark and its formulations, using HPTLC. Standard solutions of Qn, Qnd, Cn, and Cnd were appl...

    journal_title:Planta medica

    pub_type: 信件


    authors: Ravishankara MN,Shrivastava N,Padh H,Rajani M

    更新日期:2001-04-01 00:00:00

  • Potent Schistosomicidal Constituents from Garcinia brasiliensis.

    abstract::Praziquantel is the drug of choice for the treatment of schistosomiasis. However, several strains of Schistosoma mansoni are resistant to praziquantel, making it necessary to discover new drugs that might be used for its treatment. With this in mind, the properties of a schistosomicidal ethanolic extract of Garcinia b...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Castro AP,de Mattos AC,Pereira NA,Anchieta NF,Silva MS,Dias DF,Silva CA,Barros GV,Souza RL,Dos Santos MH,Marques MJ

    更新日期:2015-06-01 00:00:00

  • GABA(A) receptor modulators from the Chinese herbal drug Junci Medulla--the pith of Juncus effusus.

    abstract::The gamma-amino butyric acid (GABA) type A (GABA(A)) receptor represents a crucial target for clinical agents in the treatment of anxiety and insomnia. Using the two-microelectrode voltage clamp technique on recombinant α₁β₂γ(2S) GABA (A) receptors, effusol (1) and dehydroeffusol (2) were isolated in a bioactivity-gui...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Singhuber J,Baburin I,Khom S,Zehl M,Urban E,Hering S,Kopp B

    更新日期:2012-03-01 00:00:00

  • Targeted and untargeted phytochemistry of Ligusticum canbyi: indoleamines, phthalides, antioxidant potential, and use of metabolomics as a hypothesis-generating technique for compound discovery.

    abstract::Ligusticum canbyi (J.M. Coult & Rose) is a medicinal understory forest species used in traditional rituals and ceremonies for spiritual enlightenment and improved mental health. Very little is known about the phytochemical complexity or diversity of L. canbyi tissues or extracts. The current study was undertaken to de...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Turi CE,Murch SJ

    更新日期:2013-09-01 00:00:00

  • An in vitro Study on the Effect of Momordica charantia on Glucose Uptake and Glucose Metabolism in Rats.

    abstract::The effect of extracts of MOMORDICA CHARANTIA L. fruits on glucose metabolism and glucose uptake was investigated. The fruit of momordica, at all ripening stages, was found to contain two inhibitory compounds: one against hexokinase activity and the other against glucose uptake by rat intestinal fragments. Both inhibi...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Meir P,Yaniv Z

    更新日期:1985-02-01 00:00:00

  • Protein tyrosine phosphatase 1B (PTP1B)-inhibiting constituents from the leaves of Syzygium polyanthum.

    abstract::A methanol extract of the leaves of Syzygium polyanthum (Wight) Walp. afforded four new acylbenzene derivatives (1-4) together with seven known compounds (5-11). The structures of 1-11 were elucidated by extensive spectroscopic methods and comparison with the literature data. The new compounds 1-3 and a known compound...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Saifudin A,Tanaka K,Kadota S,Tezuka Y

    更新日期:2012-08-01 00:00:00

  • Cryptic and free skin irritants of the daphnane and tigliane types in latex of Excoecaria agallocha.

    abstract::In the extremely skin irritant and caustic latex of Excoecaria agallocha the major part of the polyfunctional diterpene esters (DTE) (group I) are aliphatic polyunsaturated 9,13,14-orthoesters of the daphnane-type parent alcohol 5 beta-hydroxyresiniferonol-6 alpha, 7 alpha-epoxide, esterified simultaneously in their 2...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Karalai C,Wiriyachitra P,Opferkuch HJ,Hecker E

    更新日期:1994-08-01 00:00:00

  • A new strain of Claviceps purpurea accumulating tetracyclic clavine alkaloids.

    abstract::A new strain of Claviceps was isolated from a blokked mutant of Claviceps purpurea. This strain accumulates substantial amounts of clavine alkaloids (2 g/l). The alkaloid fraction is composed of chanoclavine-I ( approximately 10%) and a mixture of agroclavine/elymoclavine (90%). Most suitable for alkaloid production i...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Schumann B,Erge D,Maier W,Gröger D

    更新日期:1982-05-01 00:00:00

  • Phenolic Compounds as Arginase Inhibitors: New Insights Regarding Endothelial Dysfunction Treatment.

    abstract::Endothelial dysfunction is characterised by the low bioavailability of nitric oxide with a relevant negative impact on the nitric oxide/cGMP pathway. The loss of nitric oxide/cGMP signaling may be caused by an increased arginase activity. Plant-derived substances, especially polyphenols, are compounds that have the po...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Minozzo BR,Fernandes D,Beltrame FL

    更新日期:2018-03-01 00:00:00

  • Natural compounds with aromatase inhibitory activity: an update.

    abstract::Several synthetic aromatase inhibitors are currently in clinical use for the treatment of postmenopausal women with hormone-receptor positive breast cancer. However, these treatments may lead to untoward side effects and so the search for new aromatase inhibitors continues, especially those for which the activity is p...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Balunas MJ,Kinghorn AD

    更新日期:2010-08-01 00:00:00

  • Eremophilane sesquiterpene lactones from Ligularia virgaurea ssp. oligocephala.

    abstract::From an extract of the whole plant of Ligularia virgaurea ssp. oligocephala, three new eremophilane sesquiterpene lactones, 10alpha-hydroxy-1-oxoeremophila-7(11),8(9)-dien-12,8-olide (1), 6alpha,10alpha-dihydroxy-1-oxoeremophila-7(11),8(9)-dien-12,8-olide (2), 6beta,10beta-dihydroxyeremophila-7(11),8(9)-dien-12,8-olid...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wu QX,Shi YP,Yang L

    更新日期:2004-05-01 00:00:00