Smooth muscle relaxing activity of gentiopicroside isolated from Gentiana spathacea.

Abstract:

:Bioassay directed fractionation of the (1:1) chloroform-methanol extract of Gentiana spathacea H.B.K (Gentianaceae) led to the isolation of gentiopicroside (gentiopricrin) (1), the major spasmolytic component of the plant. Gentiopicroside inhibited, in a concentration-dependent manner, the spontaneous contractions of isolated guinea pig ileum. Contractions induced by histamine, acetylcholine, BaCl2 and KCl on the ileum were also significantly blocked by this monoterpene glucoside, which suggests that this compound might be interfering with calcium influx into the smooth muscle cells.

journal_name

Planta Med

journal_title

Planta medica

authors

Rojas A,Bah M,Rojas JI,Gutiérrez DM

doi

10.1055/s-2000-9774

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

765-7

issue

8

eissn

0032-0943

issn

1439-0221

journal_volume

66

pub_type

信件
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