Triterpenoid saponins from Androsace umbellata and their anti-proliferative activities in human hepatoma cells.

abstract：:Seven coumarins were isolated from the aerial parts of Tordylium apulum; their structures were established by spectroscopic means. All compounds were tested in vitro for their cytotoxicity against two cell line systems. The antiproliferative effects for three of them were studied at the level of the cell cycle in asyn...

journal_title：Planta medica

authors： Kofinas C,Chinou I,Loukis A,Harvala C,Roussakis C,Maillard M,Hostettmann K

更新日期：1998-03-01 00:00:00

abstract：:A new cytotoxic roridin-type trichothecene macrolide named roritoxin E(1) was characterized from the solid culture of Myrothecium roridum IFB-E091 (residing originally inside Artemisia annua root), together with the known compounds lumichrome (2), (22 E,24 S)-cerevisterol (3), and (22 E,24 R)-6 beta-methoxy-ergosta-7,...

journal_title：Planta medica

authors： Shen L,Wang JS,Shen HJ,Song YC,Tan RX

更新日期：2010-07-01 00:00:00

abstract：:In the present study, we demonstrate that saucernetin-8 ( 1) and saucernetin-7 ( 2), isolated from the underground parts of Saururus chinensis (Saururaceae), exerted potent inhibitory effects on LPS-induced nitric oxide (NO) and prostaglandin E (2) (PGE (2)) production in RAW 264.7 cells. Both compounds 1 and 2, known...

journal_title：Planta medica

authors： Park HJ,Kim RG,Seo BR,Ha J,Ahn BT,Bok SH,Lee YS,Kim HJ,Lee KT

更新日期：2003-10-01 00:00:00

abstract：:We previously reported that total coumarins, the major active components of Urtica dentata Hand, exhibited substantial protection against the development of autoimmune diabetes. Diabetic nephropathy is one of the most serious complications of diabetes and is closely correlated with end-stage renal disease. We used the...

journal_title：Planta medica

authors： Cao H,Ji Y,Li W,Liu Y,Fu R,Xiang M

更新日期：2015-10-01 00:00:00

abstract：:A beta-hydroxychalcone 1, so far not reported as a natural compound, was separated from the diethyl ether extract of LEPTOSPERMUM SCOPARIUM (Myrtaceae). Furthermore, three known flavonoids 2-4 were isolated. The (13)C-NMR spectra of 2-4 are reported, since they have as yet not been reported in the literature. ...

journal_title：Planta medica

authors： Mayer R

更新日期：1993-06-01 00:00:00

abstract：:Jujuboside A (JuA) is a glycoside extracted from the seed of Ziziphus jujuba Mill var. spinosa (Bunge) Hu ex H F Chou, a Chinese herbal medicine, which has long been known as a sedative-hypnotic drug. The present study used the method of intracerebroventricular (i.c.v.) JuA in vivo to detect the effect of JuA on paire...

journal_title：Planta medica

authors： Shou C,Feng Z,Wang J,Zheng X

更新日期：2002-09-01 00:00:00

abstract：:Examined in vitro were the effects of some triterpenoids from Panax (Araliaceae) and Glycyrrhiza (Leguminosae) spp. on the sensitivity to daunomycin (DAU) and vinblastine (VBL) of adriamycin (ADM)-resistant P388 leukemia cells (P388/ADM), which were resistant to multiple anticancer drugs. Quasipanaxatriol, 20(S)-proto...

journal_title：Planta medica

authors： Hasegawa H,Sung JH,Matsumiya S,Uchiyama M,Inouye Y,Kasai R,Yamasaki K

更新日期：1995-10-01 00:00:00

abstract：:The isoflavonoids found in soy have attracted great interest as dietary phytoestrogens that might be effective for postmenopausal hormone replacement therapy. Special attention has been devoted to the hormonal effects of various isoflavonoids, like genistein (GEN) and daidzein's (DAID) potent metabolite, equol (EQ). H...

journal_title：Planta medica

authors： Tezval M,Sehmisch S,Seidlová-Wuttke D,Rack T,Kolios L,Wuttke W,Stuermer KM,Stuermer EK

更新日期：2010-02-01 00:00:00

abstract：:The anti-inflammatory effects of boldine and reticuline isolated from Litsea cubeba were evaluated by using xylene-induced ear edema and carrageenan-induced paw edema in mice and rats. Our results demonstrated that intragastric administration with boldine and reticuline significantly mitigated ear weight in mice and d...

journal_title：Planta medica

authors： Yang X,Gao X,Cao Y,Guo Q,Li S,Zhu Z,Zhao Y,Tu P,Chai X

更新日期：2018-01-01 00:00:00

abstract：:Herpes simplex virus infections persist throughout the lifetime of the host and affect more than 80 % of the humans worldwide. The intensive use of available therapeutic drugs has led to undesirable effects, such as drug-resistant strains, prompting the search for new antiherpetic agents. Although diverse bioactivitie...

journal_title：Planta medica

authors： Nocchi SR,Companhoni MV,de Mello JC,Dias Filho BP,Nakamura CV,Carollo CA,Silva DB,Ueda-Nakamura T

更新日期：2017-04-01 00:00:00

abstract：:The major alkaloids of PAPAVER TRINIIFOLIUM collected in two different parts of Anatolia have proved to be of the aporphine, morphinane and rhoeadine types. The two collections possessed different major alkaloids and the existence of chemical strains is indicated. In addition to the aporphine-(floripavidine), the morp...

journal_title：Planta medica

authors： Sariyar G

更新日期：1983-09-01 00:00:00

abstract：:A pyrolytic gaschromatographic process was developed for the routine assay of both cyclodextrin inclusion complexes, and for the differentiation of the mechanical mixture of the same oil with beta-cyclodextrin. The method is a direct assay of low material demand. ...

journal_title：Planta medica

authors： Pobozsny K,Kernóczi L,Tétényi P,Héthelyi I,Szejtli J

更新日期：1981-07-01 00:00:00

abstract：:Swertiamarin, a secoiridoid isolated from the ethyl acetate extract of Enicostemma axillare, was evaluated for antiedematogenic activity using carrageenan-, formalin-, and histamine-induced paw edema methods in rats. In the carrageenan-induced method, the percentages of edema inhibition obtained after 5 h induction we...

journal_title：Planta medica

authors： Vaijanathappa J,Badami S

更新日期：2009-01-01 00:00:00

abstract：:Six new triterpenoid saponins, psychotrianosides A-F (1-6), and two known triterpenoid saponins, psychotrianoside G (7) and ardisianoside D (8), were isolated from Psychotria sp. Their structures were determined mainly by spectroscopic methods. The cytotoxic activities of 1-8 against five human cancer cell lines (MDA-...

journal_title：Planta medica

authors： Zhang CX,Zhang DM,Chen MF,Guan SY,Yao JH,He XX,Lei LF,Zhong Y,Wang ZF,Ye WC

更新日期：2013-07-01 00:00:00

abstract：:The aim of this study was to determine the molecular mechanism underlying the inhibition of vascular restenosis by Radix Sophorae Flavescentis (RSF) extract after balloon dilatation injury. In a rat carotid model of balloon dilatation injury, the RSF extract showed a significant inhibitory effect on vascular restenosi...

journal_title：Planta medica

authors： Long G,Wang G,Ye L,Lin B,Wei D,Liu L,Yang L

更新日期：2009-10-01 00:00:00

abstract：:Transformed root cultures of ipecac (Cephaelis ipecacuanha A. Richard), one of the recalcitrant woody plant species for Agrobacterium-mediated transformation, were established by co-culturing of in vitro petiole segments with Agrobacterium rhizogenes ATCC 15 834. Southern blot analysis of the established roots reveale...

journal_title：Planta medica

authors： Yoshimatsu K,Shimomura K,Yamazaki M,Saito K,Kiuchi F

更新日期：2003-11-01 00:00:00

abstract：:Tissue callus cultures originating from CHELIDONIUM MAJUS L. seeds were established on Gamborg B5, Murashige-Skoog (MS), and Schenk-Hildebrandt (SH) media. In all experimental conditions, calli accumulated a complex pattern of isoquinoline derivatives. The highest values, both in growth and in sanguinarine production,...

journal_title：Planta medica

authors： Colombo ML,Tomé F

更新日期：1991-10-01 00:00:00

abstract：:Blue cohosh, Caulophyllum thalictroides (L.) Michx. is a popular herb, roots and rhizomes of which have been extensively used for women's health. Alkaloids and saponins are considered to be responsible for its pharmacological effects. In this investigation the methanolic extract of the roots of blue cohosh, the alkalo...

journal_title：Planta medica

authors： Madgula VL,Ali Z,Smillie T,Khan IA,Walker LA,Khan SI

更新日期：2009-03-01 00:00:00

abstract：:Annona purpurea has been traditionally used by indigenous and socioeconomically disadvantaged people to treat infectious and parasitic diseases, including amoebiasis. The goal of this study was to assess the effect of a crude methanolic extract, an alkaloid extract, and aporphine alkaloids from leaves of A. purpurea o...

journal_title：Planta medica

authors： Díaz-Godínez C,Ontiveros-Rodríguez JC,Ríos-Valencia DG,Herbert-Pucheta JE,Zepeda-Vallejo LG,Carrero JC

更新日期：2020-04-01 00:00:00

abstract：:Thyme extract is known to posses spasmolytic effects on isolated trachea and to increase ciliary activity. A small part of this effect is mediated via beta (2) receptors, but other receptors are supposed to be involved. Endothelin has a pathophysiological impact in asthma with respect to hyper-reagibility and contract...

journal_title：Planta medica

authors： Engelbertz J,Schwenk T,Kinzinger U,Schierstedt D,Verspohl EJ

更新日期：2008-10-01 00:00:00

abstract：:Seven phenolic derivatives, 2,4-bis(4-hydroxybenzyl)phenol ( 1), bis[4(beta- D-glucopyranosyloxy)-benzyl] ( S)-(-)-2-isopropylmalate ( 2), bis[4-(beta- D-gluco-pyranosyloxy)benzyl] ( S)-(-)-2-sec-butylmalate ( 3), 4-hydroxybenzyaldehyde ( 4), 4,4'-dihydroxydiphenyl-methane ( 5), 4-hydroxybenzyl alcohol ( 6), and 4-(be...

journal_title：Planta medica

authors： Yi-Ming L,Zhuo-Lun Z,Yong-Fu H

更新日期：1993-08-01 00:00:00

abstract：:Evodiamine, a major alkaloidal principle of Evodia fruits (Evodia rutaecarpa, Rutaceae), showed vanilloid receptor agonistic activities comparable to capsaicin. The Chinese literature refers to Evodia fruits as a "hot nature" herb. In spite of the similarities in the actions of evodiamine and capsaicin in vitro, evodi...

journal_title：Planta medica

authors： Kobayashi Y,Nakano Y,Kizaki M,Hoshikuma K,Yokoo Y,Kamiya T

更新日期：2001-10-01 00:00:00

abstract：:Cuttings of a clone of A. annua L. (Asteraceae), grown under 16 h photoperiod for 55 days were transferred to six photoperiod treatments in the greenhouse. Under short photoperiods (8, 10, or 12 h), plants flowered after two weeks; plants under long photoperiods (16, 20, or 24 h) remained vegetative until termination ...

journal_title：Planta medica

authors： Ferreira JF,Simon JE,Janick J

更新日期：1995-04-01 00:00:00

abstract：:The antihyperglycemic action of andrographolide, an active principle in the leaves of Andrographis paniculata (Burm. f.) Nees, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). Oral treatment of andrographolide decreased the plasma glucose concentrations of STZ-diabetic rats in a dose-depen...

journal_title：Planta medica

authors： Yu BC,Hung CR,Chen WC,Cheng JT

更新日期：2003-12-01 00:00:00

abstract：:A microdilution technique was developed for the assessment of in vitro cytotoxicity against KB cells derived from a human epidermoid carcinoma of the nasopharynx. The test was used to determine the cytotoxicity of a series of quassinoids, isolated from Brucea javanica, and which have previously been shown to demonstra...

journal_title：Planta medica

authors： Anderson MM,O'Neill MJ,Phillipson JD,Warhurst DC

更新日期：1991-02-01 00:00:00

abstract：:Rhapontin was purified from a methanol extract from the roots of Rheum undulatum, and rhapontigenin was produced by an enzymatic transformation of rhapontin. Rats were fed a high-cholesterol diet to induce hyperlipidemia, followed by oral treatment with rhapontin or rhapontigenin (1-5 mg/kg/day). Rhapontin and rhapont...

journal_title：Planta medica

authors： Jo SP,Kim JK,Lim YH

更新日期：2014-08-01 00:00:00

abstract：:A new tetrahydrofuranoketone lignan (1) and two new tetrahydrofuranoketone lignan glycosides (2, 3) were isolated from the ethanol extract of the aerial part of Mananthes patentiflora. The structure elucidations of these compounds were mainly established on the basis of 1D, 2D NMR and HR-mass spectroscopic analysis. A...

journal_title：Planta medica

authors： Tian J,Yang X,Di Y,Ma Y,Li L,Li L,He H,Hao X

更新日期：2009-04-01 00:00:00

abstract：:Silybum marianum Gaertn. (Milk thistle) has been used since ancient times for the relief of liver diseases characterized by intense oxidative stress such as inflammatory liver disease and cirrhosis. As oxidative stress by hyperglycemia is involved in micro- and macrovascular complications of type 2 diabetes, our aim w...

journal_title：Planta medica

authors： Palomino OM,Gouveia NM,Ramos S,Martín MA,Goya L

更新日期：2017-01-01 00:00:00

abstract：:In natural product research, the isolation of biomarkers or bioactive compounds from complex natural extracts represents an essential step for de novo identification and bioactivity assessment. When pure natural products have to be obtained in milligram quantities, the chromatographic steps are generally labourious an...

journal_title：Planta medica

authors： Challal S,Queiroz EF,Debrus B,Kloeti W,Guillarme D,Gupta MP,Wolfender JL

更新日期：2015-11-01 00:00:00

abstract：:A known sesquiterpene lactone, encelin, isolated from the Mexican species Montanoa speciosa (Compositae), was assayed for biocidal activity on fungal cells of Mucor rouxii. The results indicate that encelin has a determining action on growth and the morphogenetic process of fungal cells. ...

journal_title：Planta medica

authors： Sabanero M,Quijano L,Rios T,Trejo R

更新日期：1995-04-01 00:00:00