New insights into CNS development from multiomics approaches.

abstract：:Action potential conduction in myelinated nerve fibers depends on a polarized axonal membrane. Voltage-gated Na(+) and K(+) channels are clustered at nodes of Ranvier and mediate the transmembrane currents necessary for rapid saltatory conduction. Paranodal junctions flank nodes and function as attachment sites for my...

journal_title：Current opinion in neurobiology

authors： Schafer DP,Rasband MN

更新日期：2006-10-01 00:00:00

abstract：:The development of increasingly sophisticated methods for recording and manipulating neural activity is revolutionizing neuroscience. By probing how activity patterns in different types of neurons and circuits contribute to behavior, these tools can help inform mechanistic models of brain function and explain the role...

journal_title：Current opinion in neurobiology

authors： Wolff SB,Ölveczky BP

更新日期：2018-04-01 00:00:00

abstract：:The hippocampal formation has a unique and highly distributed network of intrinsic connections. What are the principles of organization that govern information flow through this system? The notion that information processing in the hippocampal formation is segregated in autonomous chips or lamellae appears to be incon...

journal_title：Current opinion in neurobiology

authors： Amaral DG

更新日期：1993-04-01 00:00:00

abstract：:Dynamics of neuronal networks can be altered in at least two ways: by changes in connectivity, that is, the physical architecture of the network, or changes in the amplitudes and kinetics of the intrinsic and synaptic currents within and between the elements making up a network. We argue that the latter changes are of...

journal_title：Current opinion in neurobiology

authors： McCarthy MM,Ching S,Whittington MA,Kopell N

更新日期：2012-08-01 00:00:00

abstract：:The gastrointestinal tract is innervated by its own enteric nervous system and by extrinsic neurons that connect it with the central nervous system. Innervation allows the gastrointestinal tract to sense and respond to diverse stimuli, adjusting motility and secretion, but also affecting our physiology, behaviour and ...

journal_title：Current opinion in neurobiology

authors： Ameku T,Beckwith H,Blackie L,Miguel-Aliaga I

更新日期：2020-06-01 00:00:00

abstract：:Neurofilaments are proteins selectively expressed in the cytoskeleton of neurons, and increased levels are a marker of damage. Elevated neurofilament levels can serve as a marker of ongoing disease activity as well as a tool to measure response to therapeutic intervention. The potential utility of neurofilaments has d...

journal_title：Current opinion in neurobiology

authors： Gordon BA

更新日期：2020-04-01 00:00:00

abstract：:The development of motor behaviour depends on the differentiation of underlying circuitry. Recent work with the zebrafish brings the simple swimming behaviour of lower vertebrates and their embryos into focus as a suitable model to study the development of motor circuitry and its genetic control. Changes in connectivi...

journal_title：Current opinion in neurobiology

authors： Bate M

更新日期：1999-12-01 00:00:00

abstract：:In recent years, interest has grown in the ability to manipulate, in a temporally precise fashion, the electrical activity of specific neurons embedded within densely wired brain circuits, in order to reveal how specific neurons subserve behaviors and neural computations, and to open up new horizons on the clinical tr...

journal_title：Current opinion in neurobiology

authors： Bernstein JG,Garrity PA,Boyden ES

更新日期：2012-02-01 00:00:00

abstract：:Upon receiving injury signals, neurons can activate various pathways to reduce harm, initiate neuroprotection, and repair damaged neurite without cell death. Here, we review recent progresses in the study of neurite repair focusing on neuronal cell-autonomous mechanisms, including new findings on ion channels that ser...

journal_title：Current opinion in neurobiology

authors： Liu HH,Jan YN

更新日期：2020-08-01 00:00:00

abstract：:Drosophila melanogaster has historically been the premier model system for understanding the molecular and genetic bases of complex behaviors. In the last decade technical advances, in the form of new genetic tools and electrophysiological and optical methods, have allowed investigators to begin to dissect the neurona...

journal_title：Current opinion in neurobiology

authors： Griffith LC

更新日期：2012-08-01 00:00:00

abstract：:How does auditory cortex represent auditory stimuli, and how do these representations contribute to behavior? Recent experimental evidence suggests that activity in auditory cortex consists of sparse and highly synchronized volleys of activity, observed both in anesthetized and awake animals. Many neurons are capable ...

journal_title：Current opinion in neurobiology

authors： Hromádka T,Zador AM

更新日期：2009-08-01 00:00:00

abstract：:Almost 30 years ago, actin was identified as the major cytoskeletal component of dendritic spines. Since then, its role in the remarkable dynamics of spine morphology have been detailed with live-cell views establishing that spine shape dynamics are an important requirement for synaptogenesis and synaptic plasticity. ...

journal_title：Current opinion in neurobiology

authors： Frost NA,Kerr JM,Lu HE,Blanpied TA

更新日期：2010-10-01 00:00:00

abstract：:The anterior cingulate cortex (ACC) and adjacent areas of the medial frontal cortex (MFC) have been implicated in monitoring behaviour and in detecting errors. Recent evidence, however, suggests that the ACC not only registers the occurrence of errors but also represents other aspects of the reinforcement history that...

journal_title：Current opinion in neurobiology

authors： Rushworth MF,Buckley MJ,Behrens TE,Walton ME,Bannerman DM

更新日期：2007-04-01 00:00:00

abstract：:Visual system development utilizes global and local cues to assemble a topographic map of the visual world, arranging synaptic connections into columns and layers. Recent genetic studies have provided new insights into the mechanisms that underlie these processes. In flies, a precise temporal sequence of neural differ...

journal_title：Current opinion in neurobiology

authors： Clandinin TR,Feldheim DA

更新日期：2009-04-01 00:00:00

abstract：:Synapses are functional units of the nervous system, through which information is transferred between neurons. The development and activity-dependent modification of synapses require temporally and spatially controlled modulation of gene expression. microRNAs (miRNAs) have emerged as essential regulators of gene expre...

journal_title：Current opinion in neurobiology

authors： Hu Z,Li Z

更新日期：2017-08-01 00:00:00

abstract：:Mammals have ∼1000 different olfactory receptor subtypes, each responding to a number of different odorants, and each odorant activating a number of different receptor subtypes. These molecular and anatomical underpinnings of olfaction imply a perceptual structure of very high dimensionality that relies on combinatori...

journal_title：Current opinion in neurobiology

authors： Secundo L,Snitz K,Sobel N

更新日期：2014-04-01 00:00:00

abstract：:Cognitive development is determined by both genetics and environment. One point of convergence of these two influences is the neural activity-dependent regulation of programs of gene expression that specify neuronal fate and function. Human genetic studies have linked several transcriptional regulators to neurodevelop...

journal_title：Current opinion in neurobiology

authors： Hong EJ,West AE,Greenberg ME

更新日期：2005-02-01 00:00:00

abstract：:AMPA receptor (AMPAR) complexes comprise four of the AMPAR subunits GluA1-4 and several additional interacting proteins. Subunit composition determines AMPAR function. However, AMPAR function depends to a large extent also on interacting proteins, which influence trafficking to the cell surface, activity-dependent sub...

journal_title：Current opinion in neurobiology

authors： Jacobi E,von Engelhardt J

更新日期：2017-08-01 00:00:00

abstract：:The pinnipeds provide a variety of clues to those interested in the vocal learning capabilities of non-human animals. Observational and experimental studies of seals, sea lions, and walruses reveal elements of vocal development, contextual control, plasticity in expression and learning, and even imitation of complex s...

journal_title：Current opinion in neurobiology

authors： Reichmuth C,Casey C

更新日期：2014-10-01 00:00:00

abstract：:Inhibitory molecules in CNS myelin affect axonal regeneration after injury. In the past year, myelin-associated glycoprotein (MAG), a well-characterized myelin protein, has been identified as an inhibitor of axonal regeneration. This finding, together with its established ability to promote outgrowth, defines MAG as a...

journal_title：Current opinion in neurobiology

authors： Filbin MT

更新日期：1995-10-01 00:00:00

abstract：:Ionotropic AMPA-type glutamate receptors and G-protein-coupled metabotropic GABAB receptors are key elements of neurotransmission whose cellular functions are determined by their protein constituents. Over the past couple of years unbiased proteomic approaches identified comprehensive sets of protein building blocks o...

journal_title：Current opinion in neurobiology

authors： Bettler B,Fakler B

更新日期：2017-08-01 00:00:00

abstract：:Mosquitoes use their sense of smell to find hosts, nectar, and oviposition sites, and to avoid repellents. A small number of mosquito species are adapted to feed on humans and have a major impact on public health by transmitting diseases such as malaria, dengue and filariasis. The application of odorants for behaviora...

journal_title：Current opinion in neurobiology

authors： Ray A

更新日期：2015-10-01 00:00:00

abstract：:Axon pathfinding is essential for the establishment of proper neuronal connections during development. Advances in neuroimaging and genomic technologies, coupled with animal modeling, are leading to the identification of an increasing number of human disorders that result from aberrant axonal wiring. In this review, w...

journal_title：Current opinion in neurobiology

authors： Nugent AA,Kolpak AL,Engle EC

更新日期：2012-10-01 00:00:00

abstract：:Social experiences throughout life influence gene expression and behavior, however, early in development these influences have a particularly profound effect. In mammals, mother-infant interactions are the primary source of social stimulation and result in long-term changes in offspring phenotype. This has previously ...

journal_title：Current opinion in neurobiology

authors： Champagne FA,Curley JP

更新日期：2005-12-01 00:00:00

abstract：:Cellular processes that mediate learning and memory show a remarkable level of conservation between vertebrates and invertebrates. Recent studies have shown that learning and memory formation in invertebrates, so-called 'simple systems', involves a highly complex arrangement of cellular pathways. Some pathways contrib...

journal_title：Current opinion in neurobiology

authors： Burrell BD,Sahley CL

更新日期：2001-12-01 00:00:00

abstract：:Sustained activity has been recorded in the prefrontal cortex during working memory tasks. First, we compare the anatomical distribution of this activity in humans and monkeys. Then, we show that it reflects many factors, maintenance of the items presented, preparation for the response, transformation of the items dur...

journal_title：Current opinion in neurobiology

authors： Passingham D,Sakai K

更新日期：2004-04-01 00:00:00

abstract：:In the last few years, work in the nascent field of neuroeconomics has advanced understanding of the brain systems involved in value-based decision making. An important modulator of valuation processes is the specific context a decision maker is facing during choice. Recently, neuroeconomics has made great progress in...

journal_title：Current opinion in neurobiology

authors： Tymula A,Plassmann H

更新日期：2016-10-01 00:00:00

abstract：:It is now 15 years since the discovery that N-methyl-d-aspartate receptor activity is required to maintain the refined topographic organization of retinotectal projections. Recent studies have identified additional components of the signaling pathways required for activity-dependent map formation and maintenance. Nitr...

journal_title：Current opinion in neurobiology

authors： Debski EA,Cline HT

更新日期：2002-02-01 00:00:00

abstract：:Recent work has helped reconcile puzzling results from brainstem transection studies first performed over 60 years ago, which suggested the existence of a sleep-promoting system in the medullary brainstem. It was specifically shown that GABAergic neurons located in the medullary brainstem parafacial zone (PZGABA) are ...

journal_title：Current opinion in neurobiology

authors： Anaclet C,Fuller PM

更新日期：2017-06-01 00:00:00

abstract：:The suprachiasmatic nucleus of the hypothalamus and at least two other unidentified central pacemakers regulate the temporal structure of a circadian network that involves almost every organ in the body. Phase control is central to the efficient function of this system. Individual circadian oscillators in tissues and ...

journal_title：Current opinion in neurobiology

authors： Menaker M,Murphy ZC,Sellix MT

更新日期：2013-10-01 00:00:00