Abstract：
:Axon pathfinding is essential for the establishment of proper neuronal connections during development. Advances in neuroimaging and genomic technologies, coupled with animal modeling, are leading to the identification of an increasing number of human disorders that result from aberrant axonal wiring. In this review, we summarize the recent clinical, genetic and molecular advances with regard to three human disorders of axon guidance: Horizontal gaze palsy with progressive scoliosis, Congenital mirror movements, and Congenital fibrosis of the extraocular muscles, Type III.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Nugent AA,Kolpak AL,Engle ECdoi
10.1016/j.conb.2012.02.006subject
Has Abstractpub_date
2012-10-01 00:00:00pages
837-43issue
5eissn
0959-4388issn
1873-6882pii
S0959-4388(12)00028-1journal_volume
22pub_type
杂志文章,评审abstract：:Accurate neural crest cell (NCC) migration requires tight control of cell adhesions, cytoskeletal dynamics and cell motility. Cadherins and RhoGTPases are critical molecular players that regulate adhesions and motility during initial delamination of NCCs from the neuroepithelium. Recent studies have revealed multiple ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2010.09.013
更新日期：2011-02-01 00:00:00
abstract：:Recent developments have led to a greater insight into the complex processes of perception of visual motion. A better understanding of the neuronal circuitry involved and advances in electrophysiological techniques have allowed researchers to alter the perception of an animal with a stimulating electrode. In addition,...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(92)90008-9
更新日期：1992-04-01 00:00:00
abstract：:General anesthesia is a man-made neurophysiological state comprised of unconsciousness, amnesia, analgesia, and immobility along with maintenance of physiological stability. Growing evidence suggests that anesthetic-induced neural oscillations are a primary mechanism of anesthetic action. Each anesthetic drug class pr...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2017.04.011
更新日期：2017-06-01 00:00:00
abstract：:The microcircuitry of the neocortex is bewildering in its anatomical detail, but seen through the filters of physiology, some simple circuits have been suggested. Intensive investigations of the cortical representation of orientation, however, show how difficult it is to achieve any consensus on what the circuits are,...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(02)00343-4
更新日期：2002-08-01 00:00:00
abstract：:New discoveries challenge the long-held view that aging is characterized by progressive loss and decline. Evidence for functional reorganization, compensation and effective interventions holds promise for a more optimistic view of neurocognitive status in later life. Complexities associated with assigning function to ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2005.03.016
更新日期：2005-04-01 00:00:00
abstract：:Metabotropic L-glutamate receptors are involved in various forms of synaptic plasticity in the hippocampus. The use of a new antagonist (LY341495) that blocks all known metabotropic L-glutamate receptors in the brain, together with subtype-selective antagonists, has identified multiple roles both for cloned and novel ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(99)80044-0
更新日期：1999-06-01 00:00:00
abstract：:Expression of vnd in ventral, ind in intermediate, and msh in dorsal columns of fly neurectoderm, and of homologous gene families in corresponding domains of vertebrate neurectoderm, suggests that elements of dorsoventral neural patterning have been evolutionarily conserved. However, upstream signaling pathways regula...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(99)00049-5
更新日期：2000-02-01 00:00:00
abstract：:This review covers the dynamic regulation of neuroligin isoforms, focusing on posttranslational events including phosphorylation, glycosylation and activity-dependent cleavage. There is a growing literature on how phosphorylation confers an isoform-specific level of modulation affecting a variety of protein interactio...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2017.05.017
更新日期：2017-08-01 00:00:00
abstract：:Cognitive development is determined by both genetics and environment. One point of convergence of these two influences is the neural activity-dependent regulation of programs of gene expression that specify neuronal fate and function. Human genetic studies have linked several transcriptional regulators to neurodevelop...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2005.01.002
更新日期：2005-02-01 00:00:00
abstract：:Activity in cortical networks is heterogeneous, sparse and often precisely timed. The functional significance of sparseness and precise spike timing is debated, but our understanding of the developmental and synaptic mechanisms that shape neuronal discharge patterns has improved. Evidence for highly specialized, selec...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2010.03.006
更新日期：2010-06-01 00:00:00
abstract：:Recent studies show that anatomical and functional brain networks exhibit similar small-world properties. However, the networks that are compared often differ in what the nodes represent (e.g. sensors or brain areas), what kind of connectivity is measured, and what temporal and spatial scales are probed. Here, I revie...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2007.03.008
更新日期：2007-04-01 00:00:00
abstract：:Here I review the diversity of GABAergic neurons in the rodent basolateral amygdala (BLA). In spite of the recent identification of the role played by certain neurons of BLA in learning and memory of fear, the diversity of GABAergic neurons has not been fully explored. I describe analogies and differences between GABA...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2014.01.006
更新日期：2014-06-01 00:00:00
abstract：:A long standing goal in motor control is to determine the fundamental output controlled by the CNS: does the CNS control the activation of individual motor units, individual muscles, groups of muscles, kinematic or dynamic features of movement, or does it simply care about accomplishing a task? Of course, the output c...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2009.09.002
更新日期：2009-12-01 00:00:00
abstract：:Endo-lysosomal pathways are essential in maintaining protein homeostasis in the cell. Numerous genes in the endo-lysosomal pathways have been found to associate with neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia (FTD). Mutations of these genes lea...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2017.09.005
更新日期：2018-02-01 00:00:00
abstract：:Though many neuronal cell fate decisions result in reproducible outcomes, stochastic choices often lead to spatial randomization of cell subtypes. This is often the case in sensory systems where expression of a specific sensory receptor gene is selected randomly from a set of possible outcomes. Here, we describe recen...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2008.04.004
更新日期：2008-02-01 00:00:00
abstract：:The control of movement relies on the precision with which motor circuits are assembled during development. Spinal motor neurons (MNs) provide the trigger to signal the appropriate sequence of muscle contractions and initiate movement. This task is accommodated by the diversification of MNs into discrete subpopulation...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2008.04.002
更新日期：2008-02-01 00:00:00
abstract：:The hippocampal formation has a unique and highly distributed network of intrinsic connections. What are the principles of organization that govern information flow through this system? The notion that information processing in the hippocampal formation is segregated in autonomous chips or lamellae appears to be incon...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(93)90214-j
更新日期：1993-04-01 00:00:00
abstract：:The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN i...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(02)00354-9
更新日期：2002-10-01 00:00:00
abstract：:Major technical advances in the imaging of live cells have led to a recent flurry of studies demonstrating how dendrites remodel dynamically during development. Taken together with our current understanding of axonal development, these studies help provide a more unified picture of how neural circuits might be formed ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(99)00059-8
更新日期：2000-02-01 00:00:00
abstract：:Functional magnetic resonance imaging (fMRI) is used widely to determine the spatial layout of brain activation associated with specific cognitive tasks at a spatial scale of millimeters. Recent methodological improvements have made it possible to determine the latency and temporal structure of the activation at a tem...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(03)00044-8
更新日期：2003-04-01 00:00:00
abstract：:During the past years, major advances have been made in understanding the sequential events involved in neural plate patterning. Positional information is already conferred to cells of the neural plate at the time of its induction in the ectoderm. The interplay between the BMP- and the Fgf- signaling pathways leads to...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2006.01.005
更新日期：2006-02-01 00:00:00
abstract：:In recent years, interest has grown in the ability to manipulate, in a temporally precise fashion, the electrical activity of specific neurons embedded within densely wired brain circuits, in order to reveal how specific neurons subserve behaviors and neural computations, and to open up new horizons on the clinical tr...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2011.10.023
更新日期：2012-02-01 00:00:00
abstract：:The molecular cloning of components involved in the cAMP second messenger cascade has allowed their biochemical characterization and revealed properties that are important for their role in sensory transduction. Recent evidence suggests inositol 1,4,5-trisphosphate functions as an additional second messenger in olfact...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(91)90079-m
更新日期：1991-08-01 00:00:00
abstract：:The biochemical basis of circadian timekeeping is best characterized in cyanobacteria. The structures of its key molecular players, KaiA, KaiB, and KaiC are known and these proteins can reconstitute a remarkable circadian oscillation in a test tube. KaiC is rhythmically phosphorylated and its phospho-status is a marke...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2013.02.012
更新日期：2013-10-01 00:00:00
abstract：:The primary reactions of the chemo-electrical signal transduction pathway in olfactory receptor neurons are mediated by two alternative second messengers, cAMP and inositol 1,4,5-trisphosphate. The rapid and transient intracellular signalling is terminated by the action of negative-feedback loops which uncouple the re...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(92)90177-m
更新日期：1992-08-01 00:00:00
abstract：:For most neurons to function properly, they need to develop synaptic specificity. This requires finding specific partner neurons, building the correct types of synapses, and fine-tuning these synapses in response to neural activity. Synaptic specificity is common at both a neuron's input and output synapses, whereby u...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2017.03.006
更新日期：2017-08-01 00:00:00
abstract：:Ankyrins are scaffolding proteins widely expressed throughout the nervous system. Ankyrins recruit diverse membrane proteins, including ion channels and cell adhesion molecules, into specialized subcellular membrane domains. These domains are stabilized by ankyrins interacting with the spectrin cytoskeleton. Ankyrin g...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2021.01.002
更新日期：2021-01-20 00:00:00
abstract：:The ability to make accurate predictions of future stimuli and consequences of one's actions are crucial for the survival and appropriate decision-making. These predictions are constantly being made at different levels of the nervous system. This is evidenced by adaptation to stimulus parameters in sensory coding, and...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2013.11.007
更新日期：2014-04-01 00:00:00
abstract：:The precise causal factors for obsessive-compulsive disorder (OCD) are not known, although, decades of research have honed in on the cortico-striatal-thalamo-cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimately linked compulsive-repetitive behaviors. Recent progress in...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2011.04.010
更新日期：2011-12-01 00:00:00
abstract：:Sound is encoded by spiral ganglion neurons (SGNs) in the hearing organ, the cochlea, with great temporal, spectral and intensity resolution. When hearing fails, electric stimulation by implanted prostheses can partially restore hearing. Optical stimulation promises a fundamental advance of hearing restoration over el...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2015.01.004
更新日期：2015-10-01 00:00:00
