A circadian clock nanomachine that runs without transcription or translation.

abstract：:Animal eyes have long served as a classical example of independent origin followed by convergence of structures onto a few different solutions. During the past decade this view has been challenged by the discovery of shared developmental regulatory genes. The Pax6 gene in particular is almost universally employed for ...

journal_title：Current opinion in neurobiology

authors： Nilsson DE

更新日期：2004-08-01 00:00:00

abstract：:The polarity of neurotransmission mediated by the gamma-amino butyric acid (GABA) type A receptor depends crucially on intracellular chloride concentration, which is largely determined by the expression and function of cation/chloride co-transporters. Recent evidence shows how both activity and neurotrophic factors ca...

journal_title：Current opinion in neurobiology

authors： Fiumelli H,Woodin MA

更新日期：2007-02-01 00:00:00

abstract：:In the mammalian cortex, the classic view assumes that the output information of a neuron is encoded in rather stereotyped action potentials, which provide an all-or-none or digital way of communication between cell body and axonal boutons. A role for subthreshold signal propagation within cortical axons has largely b...

journal_title：Current opinion in neurobiology

authors： Alle H,Geiger JR

更新日期：2008-06-01 00:00:00

abstract：:Visual perception is inherently statistical: brains exploit repeating features of natural scenes to disambiguate images that could, in principle, have many causes. A clear case for the relevance of statistical inference in vision is animal camouflage. Although visual scenes are each composed of unique arrangements of ...

journal_title：Current opinion in neurobiology

authors： Reiter S,Laurent G

更新日期：2020-02-01 00:00:00

abstract：:Schizophrenia is a disorder of cognitive neurodevelopment. At least some of the core cognitive deficits of the illness appear to be the product of impaired gamma frequency oscillations which depend, in part, on the inhibitory actions of a subpopulation of cortical GABA neurons that express the calcium binding protein ...

journal_title：Current opinion in neurobiology

authors： Lewis DA

更新日期：2014-06-01 00:00:00

abstract：:Orexin deficiency results in the sleep disorder narcolepsy in many mammalian species, including mice, dogs, and humans, suggesting that the orexin system is particularly important for normal regulation of sleep/wakefulness states, and especially for maintenance of wakefulness. This review discusses animal models of na...

journal_title：Current opinion in neurobiology

authors： Sakurai T

更新日期：2013-10-01 00:00:00

abstract：:In order to understand how brain activity produces adaptive behavior we need large-scale, high-resolution recordings of neuronal activity. Fluorescent genetically encoded voltage indicators (GEVIs) offer the potential for these recordings to be performed chronically from targeted cells in a minimally invasive manner. ...

journal_title：Current opinion in neurobiology

authors： Platisa J,Pieribone VA

更新日期：2018-06-01 00:00:00

abstract：:In the twelve years since the molecular elucidation of the metabotropic glutamate receptor subtype 1, a class III family of G-protein-coupled receptors has emerged; members of this family include the calcium-sensing receptor, the GABA(B) receptor, some odorant receptors and some taste receptors. Atomic structures of t...

journal_title：Current opinion in neurobiology

authors： Jingami H,Nakanishi S,Morikawa K

更新日期：2003-06-01 00:00:00

abstract：:Neuroscience research has become increasingly reliant upon quantitative and computational data analysis and modeling techniques. However, the vast majority of neuroscientists are still trained within the traditional biology curriculum, in which computational and quantitative approaches beyond elementary statistics may...

journal_title：Current opinion in neurobiology

authors： Goldman MS,Fee MS

更新日期：2017-10-01 00:00:00

abstract：:Oscillation in motor pattern generators is driven either by pacemaker neurons with inherent bursting properties or through network interactions. In a few examples in invertebrates and lower vertebrates, the mechanisms by which reciprocal inhibition combines with inherent membrane properties to produce network oscillat...

journal_title：Current opinion in neurobiology

authors： Calabrese RL

更新日期：1995-12-01 00:00:00

abstract：:This past year has seen significant advances in our understanding of the physiology of emotion. Attention continues to focus on the amygdala and its interconnections with prefrontal cortical regions. New evidence underscores the importance of lateralization for emotion. There are also new findings on the physiological...

journal_title：Current opinion in neurobiology

authors： Davidson RJ,Sutton SK

更新日期：1995-04-01 00:00:00

abstract：:Here I review the diversity of GABAergic neurons in the rodent basolateral amygdala (BLA). In spite of the recent identification of the role played by certain neurons of BLA in learning and memory of fear, the diversity of GABAergic neurons has not been fully explored. I describe analogies and differences between GABA...

journal_title：Current opinion in neurobiology

authors： Capogna M

更新日期：2014-06-01 00:00:00

abstract：:The adult mammalian neocortex, the major region of the cerebral cortex, is divided into functionally specialized areas, defined by distinct architecture and axonal connections. Extrinsic influences, such as thalamocortical input, and genetic regulation, intrinsic to the dorsal telencephalon, control the gradual emerge...

journal_title：Current opinion in neurobiology

authors： O'Leary DD,Nakagawa Y

更新日期：2002-02-01 00:00:00

abstract：:The aging peripheral nervous system (PNS) is prone to a number of disorders, including the development of neuropathies and increased regenerative failure. Although the basic mechanisms of the aging PNS are still rather murky, recent work has revealed that 'old' Schwann cells acquire a number of dysfunctions in mammals...

journal_title：Current opinion in neurobiology

authors： Painter MW

更新日期：2017-12-01 00:00:00

abstract：:Coordinated excitatory and inhibitory activity is required for proper brain functioning. Recent computational and experimental studies have demonstrated that activity patterns in recurrent cortical networks are dominated by inhibition. Whereas previous studies have suggested that inhibitory plasticity is important for...

journal_title：Current opinion in neurobiology

authors： Herstel LJ,Wierenga CJ

更新日期：2020-08-24 00:00:00

abstract：:Cellular processes that mediate learning and memory show a remarkable level of conservation between vertebrates and invertebrates. Recent studies have shown that learning and memory formation in invertebrates, so-called 'simple systems', involves a highly complex arrangement of cellular pathways. Some pathways contrib...

journal_title：Current opinion in neurobiology

authors： Burrell BD,Sahley CL

更新日期：2001-12-01 00:00:00

abstract：:Regulated release of neurotransmitter depends on the orchestrated function of a large number of proteins in the presynaptic compartment. When synaptic vesicles fuse with the plasma membrane, these membranes and the attached proteins are endocytosed and either recycled or degraded. This turnover needs to be tightly reg...

journal_title：Current opinion in neurobiology

authors： Lüningschrör P,Sendtner M

更新日期：2018-08-01 00:00:00

abstract：:Despite considerable skepticism, researchers have found that the patterns of muscle activation that control feeding behaviors of lower vertebrates have been surprisingly conserved during evolution. This tendency for conservation among taxa appears in the face of marked flexibility of motor patterns within individuals....

journal_title：Current opinion in neurobiology

authors： Wainwright PC

更新日期：2002-12-01 00:00:00

abstract：:Helping involves other-oriented actions that have the potential to benefit another. The last ten years has seen the introduction of several experimental paradigms to study helping in rats. In the best characterized of these, a free rat opens a door to release a rat trapped in an acrylic tube or pool of water. Helping ...

journal_title：Current opinion in neurobiology

authors： Mason P

更新日期：2021-01-23 00:00:00

abstract：:It is now 15 years since the discovery that N-methyl-d-aspartate receptor activity is required to maintain the refined topographic organization of retinotectal projections. Recent studies have identified additional components of the signaling pathways required for activity-dependent map formation and maintenance. Nitr...

journal_title：Current opinion in neurobiology

authors： Debski EA,Cline HT

更新日期：2002-02-01 00:00:00

abstract：:Endogenous nitric oxide (NO) mediates certain aspects of synaptic plasticity and neurotoxicity associated with NMDA-type glutamate receptors. Neuronal NO synthase contains a modular protein-protein interaction motif, termed the PDZ domain, that links the synthase to a synaptic protein complex containing postsynaptic d...

journal_title：Current opinion in neurobiology

authors： Brenman JE,Bredt DS

更新日期：1997-06-01 00:00:00

abstract：:Genetic mosaic techniques provide a powerful tool for dissecting gene function in the intricate genetic networks that underlie the formation and function of nervous systems. For instance, it is possible to make individual cells or groups of cells homozygous for mutations of interest at specific points during an organi...

journal_title：Current opinion in neurobiology

authors： Zugates CT,Lee T

更新日期：2004-10-01 00:00:00

abstract：:During the past few decades, we have witnessed an impressive gain in the knowledge regarding the basic mechanisms underlying human neuronal migration disorders by the usage of mouse models. Nevertheless, despite the remarkable conservation both in the genetic encoded information and the developmental processes, there ...

journal_title：Current opinion in neurobiology

authors： Reiner O,Parichha A,Sapir T

更新日期：2020-10-15 00:00:00

abstract：:Vestibulo-ocular reflexes (VOR) assist retinal image stabilization during vertebrate locomotion thereby ensuring accurate visual perception. The importance of this motor behavior for animal survival requires that the underlying circuitry and all individual components are fully developed and functional as soon as post-...

journal_title：Current opinion in neurobiology

authors： Straka H

更新日期：2010-12-01 00:00:00

abstract：:The pinnipeds provide a variety of clues to those interested in the vocal learning capabilities of non-human animals. Observational and experimental studies of seals, sea lions, and walruses reveal elements of vocal development, contextual control, plasticity in expression and learning, and even imitation of complex s...

journal_title：Current opinion in neurobiology

authors： Reichmuth C,Casey C

更新日期：2014-10-01 00:00:00

abstract：:Precise formation of neuronal circuits requires the coordinated development of the different components of the circuit. Here, we review examples of coordination at multiples scales of development in one of the best-studied systems for neural patterning and circuit assembly, the Drosophila visual system, from coordinat...

journal_title：Current opinion in neurobiology

authors： Courgeon M,Desplan C

更新日期：2019-06-01 00:00:00

abstract：:mRNA localization and regulated translation take central roles in axon guidance and synaptic plasticity. By spatially restricting gene expression within neurons, local protein synthesis provides growth cones and synapses with the capacity to autonomously regulate their structure and function. Studies in a variety of s...

journal_title：Current opinion in neurobiology

authors： Martin KC

更新日期：2004-06-01 00:00:00

abstract：:Vocalizations transmit information to social partners, and mice use these signals to exchange information during courtship. Ultrasonic vocalizations from adult males are tightly associated with their interactions with females, and vary as a function of male quality. Work in the last decade has established that the spe...

journal_title：Current opinion in neurobiology

authors： Egnor SR,Seagraves KM

更新日期：2016-06-01 00:00:00

abstract：:In the past year, our knowledge of neurotransmitter transporters has increased significantly. Recently, new members of two families of plasma membrane uptake carriers have been cloned, and the stoichiometries, physiological function and mechanisms of modulation of some of these transporters are now better understood. ...

journal_title：Current opinion in neurobiology

authors： Attwell D,Mobbs P

更新日期：1994-06-01 00:00:00

abstract：:A critical review of the role of the cerebellum in motor learning is presented. Specifically, the hypothesis that the climbing fibers that issue from the inferior olive serve to modify the responsiveness of cerebellar Purkinje cells is evaluated. It is concluded that there is no convincing evidence, at this time, to s...

journal_title：Current opinion in neurobiology

authors： Llinás R,Welsh JP

更新日期：1993-12-01 00:00:00