Abstract:
:Precise formation of neuronal circuits requires the coordinated development of the different components of the circuit. Here, we review examples of coordination at multiples scales of development in one of the best-studied systems for neural patterning and circuit assembly, the Drosophila visual system, from coordination of gene expression in photoreceptors to the coordinated patterning of the different neuropiles of the optic lobe.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Courgeon M,Desplan Cdoi
10.1016/j.conb.2019.01.024subject
Has Abstractpub_date
2019-06-01 00:00:00pages
153-159eissn
0959-4388issn
1873-6882pii
S0959-4388(18)30164-8journal_volume
56pub_type
杂志文章,评审abstract::Synapses are specialized sites of cell contact that mediate information flow between neurons and their targets. Genetic screens in the nematode C. elegans have led to the discovery of a number of molecules required for synapse patterning and assembly. Recent studies have demonstrated the importance of guidepost cells ...
journal_title:Current opinion in neurobiology
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abstract::In the past year significant advances have been made in our understanding of the role of protein dephosphorylation in the control of neuronal function. Molecular cloning has identified a large number of serine/threonine and tyrosine protein phosphatases in the nervous system. Many of these enzymes are selectively enri...
journal_title:Current opinion in neurobiology
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abstract::Identification of genetic mutations linked to familial neurodegenerative diseases have made it possible to generate useful transgenic animal models. Studies using these transgenic animals indicate that many familial neurodegenerative diseases, such as motor neuron disease, Alzheimer's disease, prion diseases and trinu...
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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abstract::Fear and anxiety are debilitating conditions that affect a significant number of individuals in their lifetimes. Understanding underlying mechanisms of these disorders affords us the possibility of therapeutic intervention. Such clarity in terms of mechanism and intervention can only come from an amalgamation of resea...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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abstract::A recent approach in social neuroscience has been the application of formal computational models for a particular social-cognitive process to neuroimaging data. Here we review preliminary findings from this nascent subfield, focusing on observational learning and strategic interactions. We present evidence consistent ...
journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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abstract::Proteoglycans are ubiquitous cell-surface and secreted glycoproteins that are involved in diverse cellular behaviors. The identities of several nervous system proteoglycans, including many of the major species in the mammalian brain, have recently come to light. In addition, recent studies have given new insights into...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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abstract::The hippocampal formation has a unique and highly distributed network of intrinsic connections. What are the principles of organization that govern information flow through this system? The notion that information processing in the hippocampal formation is segregated in autonomous chips or lamellae appears to be incon...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(93)90214-j
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abstract::Cyclic AMP response element binding protein (CREB)-responsive transcription plays a central role in the formation of long-term memory in Drosophila, Aplysia and mice. Agents that disrupt the activity of CREB specifically block the formation of long-term memory, whereas agents that increase the amount or activity of th...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章
doi:10.1016/j.conb.2017.06.007
更新日期:2017-10-01 00:00:00
abstract::Quantal neurotransmitter release at nerve terminals is tightly regulated by the presynaptic Ca2+ concentration. Here, we summarise current advances in understanding how the interplay between presynaptic Ca2+ dynamics and different Ca2+ release sensors shapes action potential-evoked release on a timescale from hundreds...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2018.05.006
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章
doi:10.1016/j.conb.2011.04.007
更新日期:2011-06-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
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doi:10.1016/s0959-4388(97)80028-1
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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abstract::The unfolded protein response (UPR) comprises kinase signaling and transcription factor activation cascades delineated over the past 20 years. Most studies conclude that this stress response is adaptive but, nevertheless, includes maladaptive programs involving CHOP expression that drives cell-autonomous apoptosis. He...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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abstract::Recent work suggests that radial glial cells represent many, if not most, of the neuronal progenitors in the developing cortex. Asymmetric cell division of radial glia results in the self-renewal of the radial glial cell and the birth of a neuron. Among the proteins that direct cell fate in Drosophila melanogaster tha...
journal_title:Current opinion in neurobiology
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abstract::Connections and interactions among distributed brain areas are increasingly recognized as the basis for cognitive operations and a diverse repertoire of behaviors. Analytic advances have allowed for brain connectivity to be represented and quantified at multiple levels: from single connections to communities and netwo...
journal_title:Current opinion in neurobiology
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abstract::Slow waves, the hallmark of NREM (Non Rapid Eye Movement) sleep, are not uniformly distributed across the cortical surface, but can occur locally and asynchronously across brain regions. Their regional distribution and amplitude is affected by brain maturation and by time spent awake, mediated in part by experience-de...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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abstract::Over the past year, evidence has accrued that adult CNS stem cells are a widespread progenitor cell type. These cells may normally replace neurons and/or glia in the adult brain and spinal cord. Advances have been made in understanding the signals that regulate stem cell proliferation and differentiation. A deeper und...
journal_title:Current opinion in neurobiology
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abstract::Feeding history and the presence of food dramatically alter chemosensory behaviors. Recent results indicate that internal nutritional state can gate peripheral gustatory and olfactory sensory responses to affect behavior. Focusing primarily on recent work in C. elegans and Drosophila, I describe the neuromodulatory me...
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abstract::The ability to make accurate predictions of future stimuli and consequences of one's actions are crucial for the survival and appropriate decision-making. These predictions are constantly being made at different levels of the nervous system. This is evidenced by adaptation to stimulus parameters in sensory coding, and...
journal_title:Current opinion in neurobiology
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abstract::Oscillation in motor pattern generators is driven either by pacemaker neurons with inherent bursting properties or through network interactions. In a few examples in invertebrates and lower vertebrates, the mechanisms by which reciprocal inhibition combines with inherent membrane properties to produce network oscillat...
journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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abstract::Recent work has established that different geometric arrangements of calcium channels are found at different presynaptic terminals, leading to a wide spectrum of calcium signals for triggering neurotransmitter release. These calcium signals are apparently transduced by synaptotagmins - calcium-binding proteins found i...
journal_title:Current opinion in neurobiology
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