Synergistic control of neurotransmitter release by different members of the synaptotagmin family.

abstract：:A recent flurry of genetic studies in mice have provided key insights into how the somatosensory system is organized at a cellular level to encode itch, pain, temperature, and touch. These studies are largely predicated on the idea that functional cell types can be identified by their unique developmental provenance a...

journal_title：Current opinion in neurobiology

authors： Gatto G,Smith KM,Ross SE,Goulding M

更新日期：2019-06-01 00:00:00

abstract：:Pruning, a process by which neurons selectively remove exuberant or unnecessary processes without causing cell death, is crucial for the establishment of mature neural circuits during animal development. Yet relatively little is known about molecular and cellular mechanisms that govern neuronal pruning. Holometabolous...

journal_title：Current opinion in neurobiology

authors： Yu F,Schuldiner O

更新日期：2014-08-01 00:00:00

abstract：:Vestibulo-ocular reflexes (VOR) assist retinal image stabilization during vertebrate locomotion thereby ensuring accurate visual perception. The importance of this motor behavior for animal survival requires that the underlying circuitry and all individual components are fully developed and functional as soon as post-...

journal_title：Current opinion in neurobiology

authors： Straka H

更新日期：2010-12-01 00:00:00

abstract：:Sensory gating mechanisms are deployed during vertebrate locomotion to ensure that adaptive and appropriate motor responses to afferent input occur during all phases of the movement cycle. Recent animal studies on the integration of cutaneous information have investigated the roles of interneurones in sensory gating. ...

journal_title：Current opinion in neurobiology

authors： Sillar KT

更新日期：1991-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a recently discovered, extensive class of small noncoding RNAs that act as post-transcriptional regulators of gene expression. miRNAs have been implicated in most aspects of animal development and in pathological processes such as cancer. In neurons, miRNAs are expressed at all stages of develop...

journal_title：Current opinion in neurobiology

authors： Schratt G

更新日期：2009-04-01 00:00:00

abstract：:Over the past decade, developmental neuroscience has been transformed by the widespread application of confocal and two-photon fluorescence microscopy. Even greater progress is imminent, as recent innovations in microscopy now enable imaging with increased depth, speed, and spatial resolution; reduced phototoxicity; a...

journal_title：Current opinion in neurobiology

authors： Wu Y,Christensen R,Colón-Ramos D,Shroff H

更新日期：2013-12-01 00:00:00

abstract：:Previously, eye positions were characterized by the direction of sight, which has two degrees of freedom for conjugate movements and three degrees of freedom for vergent movements. Several groups have recently presented reliable data and unconventional models on binocular coordination, where all three degrees of freed...

journal_title：Current opinion in neurobiology

authors： Hepp K

更新日期：1994-12-01 00:00:00

abstract：:The development of increasingly sophisticated methods for recording and manipulating neural activity is revolutionizing neuroscience. By probing how activity patterns in different types of neurons and circuits contribute to behavior, these tools can help inform mechanistic models of brain function and explain the role...

journal_title：Current opinion in neurobiology

authors： Wolff SB,Ölveczky BP

更新日期：2018-04-01 00:00:00

abstract：:Not only is the sense of smell of pivotal importance to most animals but also serves as a significant model system in biological research. In recent years, great strides in our understanding of how the olfactory system is organized and operates have been made. Instrumental in these efforts has been work performed in D...

journal_title：Current opinion in neurobiology

authors： Mansourian S,Stensmyr MC

更新日期：2015-10-01 00:00:00

abstract：:Echolocating bats exhibit accurate three-dimensional (3D) auditory localization to avoid obstacles and intercept prey. The bat achieves high spatial resolution through a biological sonar system. Key features of the bat's sonar system are (1) high frequency, directional echolocation signals; (2) high frequency hearing;...

journal_title：Current opinion in neurobiology

authors： Wohlgemuth MJ,Luo J,Moss CF

更新日期：2016-12-01 00:00:00

abstract：:Connections and interactions among distributed brain areas are increasingly recognized as the basis for cognitive operations and a diverse repertoire of behaviors. Analytic advances have allowed for brain connectivity to be represented and quantified at multiple levels: from single connections to communities and netwo...

journal_title：Current opinion in neurobiology

authors： Mišić B,Sporns O

更新日期：2016-10-01 00:00:00

abstract：:Sustained activity has been recorded in the prefrontal cortex during working memory tasks. First, we compare the anatomical distribution of this activity in humans and monkeys. Then, we show that it reflects many factors, maintenance of the items presented, preparation for the response, transformation of the items dur...

journal_title：Current opinion in neurobiology

authors： Passingham D,Sakai K

更新日期：2004-04-01 00:00:00

abstract：:The astonishing cellular diversity in the central nervous system (CNS) arises from neural progenitors which can undergo different modes of symmetric and asymmetric divisions to self-renew as well as produce differentiated neuronal and glial progeny. Drosophila CNS neural progenitor cells, neuroblasts, have been utilis...

journal_title：Current opinion in neurobiology

authors： Zhong W,Chia W

更新日期：2008-02-01 00:00:00

abstract：:The crucial role of dopamine (DA) in movement control is illustrated by the spectrum of motor disorders caused by either a deficiency or a hyperactivity of dopaminergic transmission in the basal ganglia. The degeneration of nigrostriatal DA neurons in Parkinson's disease causes poverty and slowness of movement. These ...

journal_title：Current opinion in neurobiology

authors： Cenci MA,Lindgren HS

更新日期：2007-12-01 00:00:00

abstract：:Visual attention operates by biasing competitive interactions between neural representations, favoring relevant over irrelevant visual inputs. Attention can enhance the processing of relevant information using location-based, feature-based or object-based selection mechanisms. Studies using event-related potential and...

journal_title：Current opinion in neurobiology

authors： Hopf JM,Schoenfeld MA,Heinze HJ

更新日期：2005-04-01 00:00:00

abstract：:The polarity of neurotransmission mediated by the gamma-amino butyric acid (GABA) type A receptor depends crucially on intracellular chloride concentration, which is largely determined by the expression and function of cation/chloride co-transporters. Recent evidence shows how both activity and neurotrophic factors ca...

journal_title：Current opinion in neurobiology

authors： Fiumelli H,Woodin MA

更新日期：2007-02-01 00:00:00

abstract：:The striatum is a hub in the basal ganglia circuitry controlling goal directed actions and habits. The loss of its dopaminergic (DAergic) innervation in Parkinson's disease (PD) disrupts the ability of the two principal striatal projection systems to respond appropriately to cortical and thalamic signals, resulting in...

journal_title：Current opinion in neurobiology

authors： Zhai S,Tanimura A,Graves SM,Shen W,Surmeier DJ

更新日期：2018-02-01 00:00:00

abstract：:Identification of genetic mutations linked to familial neurodegenerative diseases have made it possible to generate useful transgenic animal models. Studies using these transgenic animals indicate that many familial neurodegenerative diseases, such as motor neuron disease, Alzheimer's disease, prion diseases and trinu...

journal_title：Current opinion in neurobiology

authors： Lee MK,Borchelt DR,Wong PC,Sisodia SS,Price DL

更新日期：1996-10-01 00:00:00

abstract：:Perception, action, cognition, and emotion can now be mapped in the brain by a growing family of techniques. Positron emission tomography, functional magnetic resonance imaging, event-related electrical potentials, event-related magnetic fields, and other non-invasive imaging techniques are rapidly evolving and provid...

journal_title：Current opinion in neurobiology

authors： Fox PT,Woldorff MG

更新日期：1994-04-01 00:00:00

abstract：:Neurons utilize mRNA transport and local translation as a means to influence development and plasticity. The molecular mechanisms for this mRNA sorting involve the recognition of cis-acting sequences by distinct mRNA binding proteins that have a dual role, acting in both mRNA transport and translational regulation. Ot...

journal_title：Current opinion in neurobiology

authors： Bassell GJ,Kelic S

更新日期：2004-10-01 00:00:00

abstract：:Fine balance between loss-of water and gain-of water is essential for maintaining body fluid homeostasis. The development of neural manipulation and mapping tools has opened up new avenues to dissect the neural circuits underlying body fluid regulation. Recent studies have identified several nodes in the brain that po...

journal_title：Current opinion in neurobiology

authors： Ichiki T,Augustine V,Oka Y

更新日期：2019-08-01 00:00:00

abstract：:Recent psychophysical studies on normal subjects, as well as brain imaging studies, have revised the concepts concerning the mechanisms underlying spatial orientation during navigation tasks. The emphasis has been put on internal models that allow the prediction of a planned trajectory and are essential in the steerin...

journal_title：Current opinion in neurobiology

authors： Berthoz A,Viaud-Delmon I

更新日期：1999-12-01 00:00:00

abstract：:The recent application of molecular biological techniques to taste cells has led to the identification and cloning of a number of proteins that are involved in signal transduction. Some of these are expressed only in taste cells, whereas others are expressed at higher levels in taste cells than in other, non-sensory l...

journal_title：Current opinion in neurobiology

authors： Margolskee RF

更新日期：1993-08-01 00:00:00

abstract：:Cloning of the Huntington's disease gene uncovered huntingtin, which is remarkable for its lack of similarity with known proteins despite its large size, approximately 350 kDa. Subsequent experiments established that huntingtin has an as yet unknown function, crucial for embryonic development and neurogenesis. Recent ...

journal_title：Current opinion in neurobiology

authors： Gusella JF,MacDonald ME

更新日期：1998-06-01 00:00:00

abstract：:In the twelve years since the molecular elucidation of the metabotropic glutamate receptor subtype 1, a class III family of G-protein-coupled receptors has emerged; members of this family include the calcium-sensing receptor, the GABA(B) receptor, some odorant receptors and some taste receptors. Atomic structures of t...

journal_title：Current opinion in neurobiology

authors： Jingami H,Nakanishi S,Morikawa K

更新日期：2003-06-01 00:00:00

abstract：:The anterior cingulate cortex (ACC) and adjacent areas of the medial frontal cortex (MFC) have been implicated in monitoring behaviour and in detecting errors. Recent evidence, however, suggests that the ACC not only registers the occurrence of errors but also represents other aspects of the reinforcement history that...

journal_title：Current opinion in neurobiology

authors： Rushworth MF,Buckley MJ,Behrens TE,Walton ME,Bannerman DM

更新日期：2007-04-01 00:00:00

abstract：:Trans-synaptic interactions organize the multiple steps of synaptic development and are critical to generate fully functional neuronal circuits. While trans-synaptic interactions are primarily mediated by cell adhesion molecules (CAMs), some directly involve ionotropic glutamate receptors (iGluRs). Here, we review the...

journal_title：Current opinion in neurobiology

authors： Fossati M,Charrier C

更新日期：2020-10-29 00:00:00

abstract：:Both mammals and birds can flexibly organize their behavior over time. In mammals, the mental operations generating this ability are called executive functions and are associated with the prefrontal cortex. The corresponding structure in birds is the nidopallium caudolaterale. Anatomical, neurochemical, electrophysiol...

journal_title：Current opinion in neurobiology

authors： Güntürkün O

更新日期：2005-12-01 00:00:00

abstract：:Human children benefit from a possibly unique set of adaptations facilitating the acquisition of knowledge about material culture. They represent artifacts (human-made objects) as tools with specific functions and seek for functional information about novel objects. Even young infants pay attention to functionally rel...

journal_title：Current opinion in neurobiology

authors： Hernik M,Csibra G

更新日期：2009-02-01 00:00:00

abstract：:Depression, conceptualized as major depressive disorder (MDD), is a complex psychiatric disorder with multiple behavioral changes and alterations in various brain regions. Biochemically, serotonin and others substances like GABA, glutamate, norepinephrin, adrenaline/noradrenaline play an essential role in the pathogen...

journal_title：Current opinion in neurobiology

authors： Northoff G

更新日期：2013-02-01 00:00:00