Abstract:
:The striatum is a hub in the basal ganglia circuitry controlling goal directed actions and habits. The loss of its dopaminergic (DAergic) innervation in Parkinson's disease (PD) disrupts the ability of the two principal striatal projection systems to respond appropriately to cortical and thalamic signals, resulting in the hypokinetic features of the disease. New tools to study brain circuitry have led to significant advances in our understanding of striatal circuits and how they adapt in PD models. This short review summarizes some of these recent studies and the gaps that remain to be filled.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Zhai S,Tanimura A,Graves SM,Shen W,Surmeier DJdoi
10.1016/j.conb.2017.08.004subject
Has Abstractpub_date
2018-02-01 00:00:00pages
9-16eissn
0959-4388issn
1873-6882pii
S0959-4388(17)30135-6journal_volume
48pub_type
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