Motor axon pathfinding.

abstract：:The gut microbiome - the largest reservoir of microorganisms of the human body - is emerging as an important player in neurodevelopment and ageing as well as in brain diseases including stroke, Alzheimer's disease and Parkinson's disease. The growing knowledge on mediators and triggered pathways has advanced our under...

journal_title：Current opinion in neurobiology

authors： Benakis C,Martin-Gallausiaux C,Trezzi JP,Melton P,Liesz A,Wilmes P

更新日期：2020-04-01 00:00:00

abstract：:The use of gene transfer techniques to express novel proteins within different cellular populations has provided insights into the function and plasticity of the brain. Recently, this technique has been successfully used to explore physiological processes within the CNS and to intervene in neurodegenerative disease an...

journal_title：Current opinion in neurobiology

authors： Fisher LJ,Ray J

更新日期：1994-10-01 00:00:00

abstract：:Plasma membrane Cl- channels perform a variety of functions, including control of excitability in neurons and muscle, cell volume regulation and transepithelial transport. Structurally, three classes of Cl- channels have been identified: ligand-gated, postsynaptic Cl- channels (e.g. GABA and glycine receptors); the cy...

journal_title：Current opinion in neurobiology

authors： Jentsch TJ

更新日期：1996-06-01 00:00:00

abstract：:The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN i...

journal_title：Current opinion in neurobiology

authors： Backman S,Stambolic V,Mak T

更新日期：2002-10-01 00:00:00

abstract：:The biochemical basis of circadian timekeeping is best characterized in cyanobacteria. The structures of its key molecular players, KaiA, KaiB, and KaiC are known and these proteins can reconstitute a remarkable circadian oscillation in a test tube. KaiC is rhythmically phosphorylated and its phospho-status is a marke...

journal_title：Current opinion in neurobiology

authors： Egli M,Johnson CH

更新日期：2013-10-01 00:00:00

abstract：:The astonishing cellular diversity in the central nervous system (CNS) arises from neural progenitors which can undergo different modes of symmetric and asymmetric divisions to self-renew as well as produce differentiated neuronal and glial progeny. Drosophila CNS neural progenitor cells, neuroblasts, have been utilis...

journal_title：Current opinion in neurobiology

authors： Zhong W,Chia W

更新日期：2008-02-01 00:00:00

abstract：:The rhythmic mandible-generated close-open alternations of the mouth, responsible for the series of consonant-vowel alternations characteristic of babbling and of languages, is receiving increased attention as a possible manifestation of an ontogenetic and phylogenetic 'frame' underlying the serial organization of spe...

journal_title：Current opinion in neurobiology

authors： MacNeilage PF,Davis BL

更新日期：2001-12-01 00:00:00

abstract：:In bilaterally symmetric organisms, the midline is a critical organizing center for the developing central nervous system. There is a striking conservation of the molecules and mechanisms that control axon path finding at the midline in vertebrate and invertebrate nervous systems. The majority of axons in the CNS cros...

journal_title：Current opinion in neurobiology

authors： Evans TA,Bashaw GJ

更新日期：2010-02-01 00:00:00

abstract：:Biochemical and physiological evidence has suggested that myosins, both conventional and unconventional, are critical for neurosensory activities. In the past few years, this premise has been supported by genetic evidence that has shown that unconventional myosins are essential for the proper functioning of neurons, r...

journal_title：Current opinion in neurobiology

authors： Hasson T,Mooseker MS

更新日期：1997-10-01 00:00:00

abstract：:Fine balance between loss-of water and gain-of water is essential for maintaining body fluid homeostasis. The development of neural manipulation and mapping tools has opened up new avenues to dissect the neural circuits underlying body fluid regulation. Recent studies have identified several nodes in the brain that po...

journal_title：Current opinion in neurobiology

authors： Ichiki T,Augustine V,Oka Y

更新日期：2019-08-01 00:00:00

abstract：:Recent work suggests that radial glial cells represent many, if not most, of the neuronal progenitors in the developing cortex. Asymmetric cell division of radial glia results in the self-renewal of the radial glial cell and the birth of a neuron. Among the proteins that direct cell fate in Drosophila melanogaster tha...

journal_title：Current opinion in neurobiology

authors： Fishell G,Kriegstein AR

更新日期：2003-02-01 00:00:00

abstract：:Social experiences throughout life influence gene expression and behavior, however, early in development these influences have a particularly profound effect. In mammals, mother-infant interactions are the primary source of social stimulation and result in long-term changes in offspring phenotype. This has previously ...

journal_title：Current opinion in neurobiology

authors： Champagne FA,Curley JP

更新日期：2005-12-01 00:00:00

abstract：:Our understanding of the gut system has been revolutionized over the past decade, in particular regarding its role in immune control and psychological regulation. The vagus nerve is a crucial link between gut and brain, transmitting diverse gut-derived signals, and has been implicated in many gastrointestinal, neurolo...

journal_title：Current opinion in neurobiology

authors： Yu CD,Xu QJ,Chang RB

更新日期：2020-06-01 00:00:00

abstract：:This article reviews recent evidence suggesting that endogenous ciliary neurotrophic factor may be involved in neural responses to injury, and discusses the possibility that ciliary neurotrophic factor could have therapeutic applications in a clinical setting. The functional relevance of ciliary neurotrophic factor in...

journal_title：Current opinion in neurobiology

authors： Adler R

更新日期：1993-10-01 00:00:00

abstract：:Synapses are functional units of the nervous system, through which information is transferred between neurons. The development and activity-dependent modification of synapses require temporally and spatially controlled modulation of gene expression. microRNAs (miRNAs) have emerged as essential regulators of gene expre...

journal_title：Current opinion in neurobiology

authors： Hu Z,Li Z

更新日期：2017-08-01 00:00:00

abstract：:Trans-synaptic interactions organize the multiple steps of synaptic development and are critical to generate fully functional neuronal circuits. While trans-synaptic interactions are primarily mediated by cell adhesion molecules (CAMs), some directly involve ionotropic glutamate receptors (iGluRs). Here, we review the...

journal_title：Current opinion in neurobiology

authors： Fossati M,Charrier C

更新日期：2020-10-29 00:00:00

abstract：:Converging evidence indicates that primates have a distinct cortical image of homeostatic afferent activity that reflects all aspects of the physiological condition of all tissues of the body. This interoceptive system, associated with autonomic motor control, is distinct from the exteroceptive system (cutaneous mecha...

journal_title：Current opinion in neurobiology

authors： Craig AD

更新日期：2003-08-01 00:00:00

abstract：:The emergence of neuronal diversity during development of the nervous system relies on dynamic changes in the epigenetic landscape of neural stem cells and their progeny. Targeted DamID (TaDa) is proving invaluable in identifying the genome-wide binding sites of chromatin-associated proteins in vivo, without fixation,...

journal_title：Current opinion in neurobiology

authors： van den Ameele J,Krautz R,Brand AH

更新日期：2019-06-01 00:00:00

abstract：:Recent advances in the identification of factors that inhibit axon extension lead us to suggest that there exist at least two functionally distinct categories of inhibitory factors: those that inhibit the motile apparatus of the growth cone, and those that destabilize interactions of the growth cone with the substratu...

journal_title：Current opinion in neurobiology

authors： Luo Y,Raper JA

更新日期：1994-10-01 00:00:00

abstract：:The ionotropic GABA receptor (GABAAR) mediates fast inhibition in the brain. The GABAAR pore-forming (α, β, and non-α/β) subunits were isolated approximately 30 years ago and have since been the focus of extensive studies. As a result, many properties of GABAARs, including subunit assembly and channel and pharmacologi...

journal_title：Current opinion in neurobiology

authors： Tomita S

更新日期：2019-08-01 00:00:00

abstract：:Adult somatic stem cells are generally defined as cells with the ability to differentiate into multiple different lineages and to self-renew during long periods of time. These features were long presumed to be represented in one single tissue-specific stem cell. Recent development of single-cell technologies reveals t...

journal_title：Current opinion in neurobiology

authors： Llorens-Bobadilla E,Martin-Villalba A

更新日期：2017-02-01 00:00:00

abstract：:The term imprinting is used to refer to biologically relevant learning during a sensitive period defined by a particular developmental stage or physiological state. Although olfactory imprinting may occur at any age, and some of the best-studied paradigms involve adult animals, recent reports of long-term memory for o...

journal_title：Current opinion in neurobiology

authors： Hudson R

更新日期：1993-08-01 00:00:00

abstract：:Priming is a nonconscious form of memory in which an encounter with a stimulus influences the subsequent identification, production or classification of the same or a related stimulus. Neuroimaging studies have revealed that behavioral priming is typically accompanied by reduced activity in several cortical regions. W...

journal_title：Current opinion in neurobiology

authors： Schacter DL,Wig GS,Stevens WD

更新日期：2007-04-01 00:00:00

abstract：:Recent progress in our understanding of the trafficking of potassium channels can be seen in particular when considering the Kv-type channels. To date, we have discovered that folding of the Kv1.3 T1 domain begins in the ribosomal exit tunnel, and that the cell surface expression of Kv4 channels is enhanced by the pre...

journal_title：Current opinion in neurobiology

authors： Heusser K,Schwappach B

更新日期：2005-06-01 00:00:00

abstract：:The unfolded protein response (UPR) comprises kinase signaling and transcription factor activation cascades delineated over the past 20 years. Most studies conclude that this stress response is adaptive but, nevertheless, includes maladaptive programs involving CHOP expression that drives cell-autonomous apoptosis. He...

journal_title：Current opinion in neurobiology

authors： Gow A,Wrabetz L

更新日期：2009-10-01 00:00:00

abstract：:Voltage-gated ion channels are composed of pore-forming subunits, as well as auxiliary subunits that modify the functions of these channels. In addition, the channels interact with other modulatory proteins in a more transient manner, although with significant effects on channel activity. Even though many second-messe...

journal_title：Current opinion in neurobiology

authors： Adelman JP

更新日期：1995-06-01 00:00:00

abstract：:Human children benefit from a possibly unique set of adaptations facilitating the acquisition of knowledge about material culture. They represent artifacts (human-made objects) as tools with specific functions and seek for functional information about novel objects. Even young infants pay attention to functionally rel...

journal_title：Current opinion in neurobiology

authors： Hernik M,Csibra G

更新日期：2009-02-01 00:00:00

abstract：:The idea that visual signals relayed by the parvocellular and magnocellular subdivisions of the lateral geniculate nucleus remain segregated in the cerebral cortex has attracted considerable attention. It has been proposed that parvocellular contributions dominate in the temporal visual cortex, and that magnocellular ...

journal_title：Current opinion in neurobiology

authors： Maunsell JH

更新日期：1992-08-01 00:00:00

abstract：:Endogenous nitric oxide (NO) mediates certain aspects of synaptic plasticity and neurotoxicity associated with NMDA-type glutamate receptors. Neuronal NO synthase contains a modular protein-protein interaction motif, termed the PDZ domain, that links the synthase to a synaptic protein complex containing postsynaptic d...

journal_title：Current opinion in neurobiology

authors： Brenman JE,Bredt DS

更新日期：1997-06-01 00:00:00

abstract：:The investigation of mechanosensory feedback to locomotion has been hindered by the challenge of recording neurons in motion. Genetic accessibility and optical transparency of zebrafish larvae provide means to revisit this question. Glutamatergic Rohon-Beard (RB) and GABAergic CSF-contacting neurons (CSF-cNs) are spin...

journal_title：Current opinion in neurobiology

authors： Knafo S,Wyart C

更新日期：2018-10-01 00:00:00