Abstract:
:Our understanding of the gut system has been revolutionized over the past decade, in particular regarding its role in immune control and psychological regulation. The vagus nerve is a crucial link between gut and brain, transmitting diverse gut-derived signals, and has been implicated in many gastrointestinal, neurological, and immunological disorders. Using state-of-the-art technologies including single-cell genomic analysis, real-time neural activity recording, trans-synaptic tracing, and electron microscopy, novel physiological functions of vagal gut afferents have been uncovered, and new gut-to-brain pathways have been revealed. Here, we review the most recent findings on vagal sensory neurons and the gut-brain signaling, focusing on the anatomical basis and the underlying molecular and cellular mechanisms. Such new discoveries explain some of the old puzzling problems and also raise new questions in this exciting and rapidly growing field.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Yu CD,Xu QJ,Chang RBdoi
10.1016/j.conb.2020.03.006subject
Has Abstractpub_date
2020-06-01 00:00:00pages
133-140eissn
0959-4388issn
1873-6882pii
S0959-4388(20)30063-5journal_volume
62pub_type
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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