How does calcium trigger neurotransmitter release?

Abstract:

:Recent work has established that different geometric arrangements of calcium channels are found at different presynaptic terminals, leading to a wide spectrum of calcium signals for triggering neurotransmitter release. These calcium signals are apparently transduced by synaptotagmins - calcium-binding proteins found in synaptic vesicles. New biochemical results indicate that all synaptotagmins undergo calcium-dependent interactions with membrane lipids and a number of other presynaptic proteins, but which of these interactions is responsible for calcium-triggered transmitter release remains unclear.

journal_name

Curr Opin Neurobiol

authors

Augustine GJ

doi

10.1016/s0959-4388(00)00214-2

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

320-6

issue

3

eissn

0959-4388

issn

1873-6882

pii

S0959-4388(00)00214-2

journal_volume

11

pub_type

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