Abstract：
:GABAergic interneurons in the hippocampus coordinate neuronal activity that gives rise to network oscillations. In this article we present advances in our understanding of how different classes of hippocampal interneurons contribute to distinct hippocampal network oscillations. We focus on two main experimental approaches that were recently applied in awake animals. Firstly, we review experiments in which selective activation or inhibition of subgroups of GABAergic interneurons was used to asses their contribution to network oscillations. Secondly, we present work that provides a first characterization of the firing activity of anatomically identified interneurons in the hippocampus of behaving animals.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Allen K,Monyer Hdoi
10.1016/j.conb.2014.08.016subject
Has Abstractpub_date
2015-04-01 00:00:00pages
81-7eissn
0959-4388issn
1873-6882pii
S0959-4388(14)00178-0journal_volume
31pub_type
杂志文章,评审abstract：:A fundamental but unsolved problem in neuroscience is how connections between neurons might underlie information processing in central circuits. Building wiring diagrams of neural networks may accelerate our understanding of how they compute. But even if we had wiring diagrams, it is critical to know what neurons in a...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2011.07.004
更新日期：2011-10-01 00:00:00
abstract：:mRNA localization and regulated translation take central roles in axon guidance and synaptic plasticity. By spatially restricting gene expression within neurons, local protein synthesis provides growth cones and synapses with the capacity to autonomously regulate their structure and function. Studies in a variety of s...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2004.05.009
更新日期：2004-06-01 00:00:00
abstract：:A novel multigene family has been identified that is likely to encode odorant receptors on olfactory sensory neurons. Further studies on this gene family are likely to shed light on the molecular mechanisms underlying information coding in the mammalian olfactory system. This review is also published in Current Opinio...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(92)90116-3
更新日期：1992-06-01 00:00:00
abstract：:The precise causal factors for obsessive-compulsive disorder (OCD) are not known, although, decades of research have honed in on the cortico-striatal-thalamo-cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimately linked compulsive-repetitive behaviors. Recent progress in...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2011.04.010
更新日期：2011-12-01 00:00:00
abstract：:The olfactory bulb and piriform cortex are the best studied structures of the mammalian olfactory system and are heavily innervated by extrinsic neuromodulatory inputs. The state-dependent release of acetylcholine, norepinephrine, serotonin, and other neuromodulators into these olfactory structures alters a constellat...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2016.07.006
更新日期：2016-10-01 00:00:00
abstract：:Heterogeneity among progenitor cells in the vertebrate nervous system has been documented with increasing frequency over the past few years. It has become clear that differences in progenitor cells help to determine when and how they respond to environmental signals. More recent studies have begun to elucidate the mol...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(98)80006-8
更新日期：1998-02-01 00:00:00
abstract：:We discuss very recent experiments with rodents addressing the idea that long-term memories initially depending on the hippocampus, over a prolonged period, become independent of it. No unambiguous recent evidence exists to substantiate that this occurs. Most experiments find that recent and remote memories are equall...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章
doi：10.1016/j.conb.2011.04.007
更新日期：2011-06-01 00:00:00
abstract：:Drosophila melanogaster has historically been the premier model system for understanding the molecular and genetic bases of complex behaviors. In the last decade technical advances, in the form of new genetic tools and electrophysiological and optical methods, have allowed investigators to begin to dissect the neurona...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2012.01.002
更新日期：2012-08-01 00:00:00
abstract：:Chronic administration of opiates or cocaine has been shown to alter the activity or expression of diverse types of cellular proteins in specific target neurons within the central nervous system. Prominent examples include signaling proteins, such as receptors, G proteins, second-messenger synthetic enzymes, and prote...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(97)80094-3
更新日期：1997-10-01 00:00:00
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journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2014.07.014
更新日期：2014-10-01 00:00:00
abstract：:Recent experiments on the retina have examined the effectiveness of various factors (e.g. growth factors, neurotrophins and cytokines) for enhancing survival and reducing injury of retinal neurons, such as photoreceptors and ganglion cells, whose death leads to blindness in degenerative retinal diseases. It has also b...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(94)90052-3
更新日期：1994-08-01 00:00:00
abstract：:Quantal neurotransmitter release at nerve terminals is tightly regulated by the presynaptic Ca2+ concentration. Here, we summarise current advances in understanding how the interplay between presynaptic Ca2+ dynamics and different Ca2+ release sensors shapes action potential-evoked release on a timescale from hundreds...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2018.05.006
更新日期：2018-08-01 00:00:00
abstract：:Neuropeptide Y is an important regulator of energy intake and expenditure. The central portion of this regulatory system appears to reside in the arcuate nucleus/paraventricular nucleus of the hypothalamus. The effects of neuropeptide Y on energy metabolism include increased food intake, decreased thermogenesis and in...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(92)90144-a
更新日期：1992-12-01 00:00:00
abstract：:In recent years, as our understanding of the pattern-generating networks responsible for a variety of behaviors has increased, the interactions of multiple neural networks have been examined in a number of systems. These studies have shown that functionally related pattern generators can interact extensively, and that...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(95)80108-1
更新日期：1995-12-01 00:00:00
abstract：:Unravelling the mechanisms of learning and memory can, and should, be tackled at many levels. Discovery of the huge family of odourant receptor genes provided olfaction with 'molecular' respectability similar to that afforded to the visual system. Consequently, molecular studies have dominated the olfactory literature...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(95)80009-3
更新日期：1995-08-01 00:00:00
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journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2014.03.017
更新日期：2014-12-01 00:00:00
abstract：:Feeding history and the presence of food dramatically alter chemosensory behaviors. Recent results indicate that internal nutritional state can gate peripheral gustatory and olfactory sensory responses to affect behavior. Focusing primarily on recent work in C. elegans and Drosophila, I describe the neuromodulatory me...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2012.08.001
更新日期：2013-02-01 00:00:00
abstract：:Recent findings suggest that cerebral laterality will not be understood in terms of simple dichotomies, such as the idea that the left hemisphere is analytic and the right holistic. Rather, hemisphere differences can be better explained in terms of relatively specific principles that extend over limited domains. For v...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(93)90208-g
更新日期：1993-04-01 00:00:00
abstract：:Connections and interactions among distributed brain areas are increasingly recognized as the basis for cognitive operations and a diverse repertoire of behaviors. Analytic advances have allowed for brain connectivity to be represented and quantified at multiple levels: from single connections to communities and netwo...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2016.05.003
更新日期：2016-10-01 00:00:00
abstract：:Inhibitory molecules in CNS myelin affect axonal regeneration after injury. In the past year, myelin-associated glycoprotein (MAG), a well-characterized myelin protein, has been identified as an inhibitor of axonal regeneration. This finding, together with its established ability to promote outgrowth, defines MAG as a...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(95)80063-8
更新日期：1995-10-01 00:00:00
abstract：:Most high-level sensory neurons have complex, nonlinear response properties; a comprehensive characterization of these properties remains a formidable challenge. Recent studies using complex sensory stimuli combined with linear and nonlinear analyses have provided new insights into the neuronal response properties in ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(00)00232-4
更新日期：2001-08-01 00:00:00
abstract：:Fine balance between loss-of water and gain-of water is essential for maintaining body fluid homeostasis. The development of neural manipulation and mapping tools has opened up new avenues to dissect the neural circuits underlying body fluid regulation. Recent studies have identified several nodes in the brain that po...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2019.01.014
更新日期：2019-08-01 00:00:00
abstract：:The crustacean stomatogastric nervous system is a long-standing test bed for studies of circuit dynamics and neuromodulation. We give a brief update on the most recent work on this system, with an emphasis on the broader implications for understanding neural circuits. In particular, we focus on new findings underlinin...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2016.07.005
更新日期：2016-12-01 00:00:00
abstract：:In order to understand how brain activity produces adaptive behavior we need large-scale, high-resolution recordings of neuronal activity. Fluorescent genetically encoded voltage indicators (GEVIs) offer the potential for these recordings to be performed chronically from targeted cells in a minimally invasive manner. ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2018.02.006
更新日期：2018-06-01 00:00:00
abstract：:The recent invention of super-resolution fluorescence microscopy brings more than an order of magnitude gain in the spatial resolution of light microscopy. New opportunities keep emerging with the multicolor, three-dimensional, and live imaging functionalities gained in the past three years. The power of this technolo...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2010.07.006
更新日期：2010-10-01 00:00:00
abstract：:How does auditory cortex represent auditory stimuli, and how do these representations contribute to behavior? Recent experimental evidence suggests that activity in auditory cortex consists of sparse and highly synchronized volleys of activity, observed both in anesthetized and awake animals. Many neurons are capable ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2009.07.009
更新日期：2009-08-01 00:00:00
abstract：:Echolocating bats exhibit accurate three-dimensional (3D) auditory localization to avoid obstacles and intercept prey. The bat achieves high spatial resolution through a biological sonar system. Key features of the bat's sonar system are (1) high frequency, directional echolocation signals; (2) high frequency hearing;...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2016.08.002
更新日期：2016-12-01 00:00:00
abstract：:Recent work has helped reconcile puzzling results from brainstem transection studies first performed over 60 years ago, which suggested the existence of a sleep-promoting system in the medullary brainstem. It was specifically shown that GABAergic neurons located in the medullary brainstem parafacial zone (PZGABA) are ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2017.04.004
更新日期：2017-06-01 00:00:00
abstract：:A recent approach in social neuroscience has been the application of formal computational models for a particular social-cognitive process to neuroimaging data. Here we review preliminary findings from this nascent subfield, focusing on observational learning and strategic interactions. We present evidence consistent ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2013.02.007
更新日期：2013-06-01 00:00:00
abstract：:The suprachiasmatic nucleus of the hypothalamus and at least two other unidentified central pacemakers regulate the temporal structure of a circadian network that involves almost every organ in the body. Phase control is central to the efficient function of this system. Individual circadian oscillators in tissues and ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2013.03.003
更新日期：2013-10-01 00:00:00
