Abstract:
:We discuss very recent experiments with rodents addressing the idea that long-term memories initially depending on the hippocampus, over a prolonged period, become independent of it. No unambiguous recent evidence exists to substantiate that this occurs. Most experiments find that recent and remote memories are equally affected by hippocampus damage. Nearly all experiments that report spared remote memories suffer from two problems: retrieval could be based upon substantial regions of spared hippocampus and recent memory is tested at intervals that are of the same order of magnitude as cellular consolidation. Accordingly, we point the way beyond systems consolidation theories, both the Standard Model of Consolidation and the Multiple Trace Theory, and propose a simpler multiple storage site hypothesis. On this view, with event reiterations, different memory representations are independently established in multiple networks. Many detailed memories always depend on the hippocampus; the others may be established and maintained independently.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Sutherland RJ,Lehmann Hdoi
10.1016/j.conb.2011.04.007subject
Has Abstractpub_date
2011-06-01 00:00:00pages
446-51issue
3eissn
0959-4388issn
1873-6882pii
S0959-4388(11)00065-1journal_volume
21pub_type
杂志文章abstract::Studies of the function of the basal forebrain have focused on cholinergic neurons that project to cortical and limbic structures critical for various cognitive abilities. Recent experiments suggest that these neurons serve a modulatory function in cognition, by optimizing cortical information processing and influenci...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(99)80024-5
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2017.02.009
更新日期:2017-06-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(91)90017-2
更新日期:1991-06-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2019.10.010
更新日期:2020-02-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(93)90124-h
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(92)90144-a
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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更新日期:1998-04-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2018.08.012
更新日期:2019-02-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(00)00232-4
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2004.03.010
更新日期:2004-04-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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更新日期:2003-06-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2004.08.010
更新日期:2004-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1994-12-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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更新日期:1998-12-01 00:00:00
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journal_title:Current opinion in neurobiology
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doi:10.1016/j.conb.2019.01.017
更新日期:2019-08-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00