Abstract:
:Slow wave activity (SWA) during slow wave sleep (SWS) is the best indicator of the sleep homeostasis. The intensity of the SWA observed during SWS that follows prolonged waking is directly correlated with the duration of prior waking and its intensity decays during SWS suggesting a buildup and a resolution of sleep need. This sleep-homeostasis related SWA results from a buildup and decay of extracellular adenosine that acts at neuronal adenosine A1 receptors to facilitate SWA and is metabolized by adenosine kinase found in glia. This local neuronal-glial circuit for homeostatic SWA is primarily under the requisite control of two genes, the Adora1 and Adk, encoding the responsible adenosine receptor and adenosine's highest affinity metabolizing enzyme.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Greene RW,Bjorness TE,Suzuki Adoi
10.1016/j.conb.2017.05.015subject
Has Abstractpub_date
2017-06-01 00:00:00pages
236-242eissn
0959-4388issn
1873-6882pii
S0959-4388(17)30046-6journal_volume
44pub_type
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