Dysconnectivity, large-scale networks and neuronal dynamics in schizophrenia.

abstract：:Cell-cell communication directs the development of photoreceptor cells in the Drosophila retina. A recent set of studies has provided a genetic dissection of one of these interactions, the induction of the R7 photoreceptor cell by the neighboring R8 photoreceptor cell. The results from these experiments shape our unde...

journal_title：Current opinion in neurobiology

authors： Krämer H,Cagan RL

更新日期：1994-02-01 00:00:00

abstract：:Drosophila melanogaster has historically been the premier model system for understanding the molecular and genetic bases of complex behaviors. In the last decade technical advances, in the form of new genetic tools and electrophysiological and optical methods, have allowed investigators to begin to dissect the neurona...

journal_title：Current opinion in neurobiology

authors： Griffith LC

更新日期：2012-08-01 00:00:00

abstract：:Facial interactions are prominent behaviors in primates. Primate facial signaling, which includes the expression of emotions, mimicking of facial movements, and gaze interactions, is visually dominated. Correspondingly, in primate brains an elaborate network of face processing areas exists within visual cortex. But ot...

journal_title：Current opinion in neurobiology

authors： Brecht M,Freiwald WA

更新日期：2012-04-01 00:00:00

abstract：:The adult mammalian neocortex, the major region of the cerebral cortex, is divided into functionally specialized areas, defined by distinct architecture and axonal connections. Extrinsic influences, such as thalamocortical input, and genetic regulation, intrinsic to the dorsal telencephalon, control the gradual emerge...

journal_title：Current opinion in neurobiology

authors： O'Leary DD,Nakagawa Y

更新日期：2002-02-01 00:00:00

abstract：:Action potential conduction in myelinated nerve fibers depends on a polarized axonal membrane. Voltage-gated Na(+) and K(+) channels are clustered at nodes of Ranvier and mediate the transmembrane currents necessary for rapid saltatory conduction. Paranodal junctions flank nodes and function as attachment sites for my...

journal_title：Current opinion in neurobiology

authors： Schafer DP,Rasband MN

更新日期：2006-10-01 00:00:00

abstract：:Ionotropic AMPA-type glutamate receptors and G-protein-coupled metabotropic GABAB receptors are key elements of neurotransmission whose cellular functions are determined by their protein constituents. Over the past couple of years unbiased proteomic approaches identified comprehensive sets of protein building blocks o...

journal_title：Current opinion in neurobiology

authors： Bettler B,Fakler B

更新日期：2017-08-01 00:00:00

abstract：:Vestibulo-ocular reflexes (VOR) assist retinal image stabilization during vertebrate locomotion thereby ensuring accurate visual perception. The importance of this motor behavior for animal survival requires that the underlying circuitry and all individual components are fully developed and functional as soon as post-...

journal_title：Current opinion in neurobiology

authors： Straka H

更新日期：2010-12-01 00:00:00

abstract：:In the past year, several key molecular components of the RNA trafficking pathway in myelinating cells have been identified: distinct cis-acting elements for RNA transport and localization have been characterized in myelin basic protein mRNA; hnRNP A2 has been identified as a trans-acting factor in oligodendrocytes th...

journal_title：Current opinion in neurobiology

authors： Carson JH,Kwon S,Barbarese E

更新日期：1998-10-01 00:00:00

abstract：:Dendritic spines are small actin-rich protrusions on the surface of dendrites whose morphological and molecular plasticity play key roles in learning and memory. Both the form and function of spines are critically dependent on the actin cytoskeleton. However, new research, using electron microscopy and live-cell super...

journal_title：Current opinion in neurobiology

authors： Dent EW,Merriam EB,Hu X

更新日期：2011-02-01 00:00:00

abstract：:Sleep has been universally conserved across animal species. The basic functions of sleep remain unclear, but insufficient sleep impairs memory acquisition and retention in both vertebrates and invertebrates. Sleep is also a homeostatic process that is influenced not only by the amount of time awake, but also by neural...

journal_title：Current opinion in neurobiology

authors： Donlea JM

更新日期：2019-02-01 00:00:00

abstract：:The idea that visual signals relayed by the parvocellular and magnocellular subdivisions of the lateral geniculate nucleus remain segregated in the cerebral cortex has attracted considerable attention. It has been proposed that parvocellular contributions dominate in the temporal visual cortex, and that magnocellular ...

journal_title：Current opinion in neurobiology

authors： Maunsell JH

更新日期：1992-08-01 00:00:00

abstract：:Work in cortically controlled neuroprosthetic systems has concentrated on decoding natural behaviors from neural activity, with the idea that if the behavior could be fully decoded it could be duplicated using an artificial system. Initial estimates from this approach suggested that a high-fidelity signal comprised of...

journal_title：Current opinion in neurobiology

authors： Tillery SI,Taylor DM

更新日期：2004-12-01 00:00:00

abstract：:The established function of oligodendrocytes and their progenitors is to drive the cellular events of myelination, a highly diversified process necessary to match the needs of various neuronal subtypes and networks. The morphological and molecular heterogeneity of oligodendrocytes and their progenitors point to functi...

journal_title：Current opinion in neurobiology

authors： Dimou L,Simons M

更新日期：2017-12-01 00:00:00

abstract：:Powerful advances in neuroimaging techniques have added to and refined classical descriptions of the neurobiology of language in adults. Recent studies have employed these methodologies to study the nature and extent of plasticity of language-relevant aspects of cerebral organization in adults, in early and late bilin...

journal_title：Current opinion in neurobiology

authors： Neville HJ,Bavelier D

更新日期：1998-04-01 00:00:00

abstract：:The anterior cingulate cortex (ACC) and adjacent areas of the medial frontal cortex (MFC) have been implicated in monitoring behaviour and in detecting errors. Recent evidence, however, suggests that the ACC not only registers the occurrence of errors but also represents other aspects of the reinforcement history that...

journal_title：Current opinion in neurobiology

authors： Rushworth MF,Buckley MJ,Behrens TE,Walton ME,Bannerman DM

更新日期：2007-04-01 00:00:00

abstract：:Rett syndrome (RTT) is one of the most common causes of intellectual and developmental disabilities in girls, and is caused by mutations in the gene encoding methyl-CpG binding protein 2 (MECP2). Here we will review our current understanding of RTT, the landscape of pathogenic mutations and function of MeCP2, and culm...

journal_title：Current opinion in neurobiology

authors： Lavery LA,Zoghbi HY

更新日期：2019-12-01 00:00:00

abstract：:Fine balance between loss-of water and gain-of water is essential for maintaining body fluid homeostasis. The development of neural manipulation and mapping tools has opened up new avenues to dissect the neural circuits underlying body fluid regulation. Recent studies have identified several nodes in the brain that po...

journal_title：Current opinion in neurobiology

authors： Ichiki T,Augustine V,Oka Y

更新日期：2019-08-01 00:00:00

abstract：:Adult somatic stem cells are generally defined as cells with the ability to differentiate into multiple different lineages and to self-renew during long periods of time. These features were long presumed to be represented in one single tissue-specific stem cell. Recent development of single-cell technologies reveals t...

journal_title：Current opinion in neurobiology

authors： Llorens-Bobadilla E,Martin-Villalba A

更新日期：2017-02-01 00:00:00

abstract：:The gastrointestinal tract is innervated by its own enteric nervous system and by extrinsic neurons that connect it with the central nervous system. Innervation allows the gastrointestinal tract to sense and respond to diverse stimuli, adjusting motility and secretion, but also affecting our physiology, behaviour and ...

journal_title：Current opinion in neurobiology

authors： Ameku T,Beckwith H,Blackie L,Miguel-Aliaga I

更新日期：2020-06-01 00:00:00

abstract：:mRNA localization and regulated translation take central roles in axon guidance and synaptic plasticity. By spatially restricting gene expression within neurons, local protein synthesis provides growth cones and synapses with the capacity to autonomously regulate their structure and function. Studies in a variety of s...

journal_title：Current opinion in neurobiology

authors： Martin KC

更新日期：2004-06-01 00:00:00

abstract：:Recent progress in our understanding of the trafficking of potassium channels can be seen in particular when considering the Kv-type channels. To date, we have discovered that folding of the Kv1.3 T1 domain begins in the ribosomal exit tunnel, and that the cell surface expression of Kv4 channels is enhanced by the pre...

journal_title：Current opinion in neurobiology

authors： Heusser K,Schwappach B

更新日期：2005-06-01 00:00:00

abstract：:Orexin deficiency results in the sleep disorder narcolepsy in many mammalian species, including mice, dogs, and humans, suggesting that the orexin system is particularly important for normal regulation of sleep/wakefulness states, and especially for maintenance of wakefulness. This review discusses animal models of na...

journal_title：Current opinion in neurobiology

authors： Sakurai T

更新日期：2013-10-01 00:00:00

abstract：:A number of laboratories have recently refined descriptions of temporal response properties, from the auditory periphery to the midbrain. At many levels of the auditory pathway, the role of inhibition in temporal coding of complex sounds is being explored. In addition, quantitative relationships between physiology and...

journal_title：Current opinion in neurobiology

authors： Carney LH

更新日期：1999-08-01 00:00:00

abstract：:The analysis of stimulus/response patterns using information theoretic approaches requires the full probability distribution of stimuli and response. Recent progress in using information-based tools to understand circuit function has advanced understanding of neural coding at the single cell and population level. In a...

journal_title：Current opinion in neurobiology

authors： Fairhall A,Shea-Brown E,Barreiro A

更新日期：2012-08-01 00:00:00

abstract：:Acetylcholine is the specific chemical code of spinal nerve terminal transmission at the mammalian neuromuscular junction (NMJ), whereas nicotinic acetylcholine receptors inserted into the membrane of muscle fibres mediate signalling for the muscle response. Glutamate has a primary role in neuromuscular transmission o...

journal_title：Current opinion in neurobiology

authors： Pizzi M,Brunelli G,Barlati S,Spano P

更新日期：2006-06-01 00:00:00

abstract：:The basal ganglia, with their inhibitory efferents, control motor outputs either directly by their projections to the midbrain motor regions or indirectly through the thalamic nuclei. Neural mechanisms in the basal ganglia act selectively to remove or enhance the inhibition so that different combinations of motor sign...

journal_title：Current opinion in neurobiology

authors： Hikosaka O

更新日期：1991-12-01 00:00:00

abstract：:Recent advances in neural and behavioural pharmacology, and in intracellular recording suggest that arousal during the awake state may be regulated by multiple, interdependent neurotransmitter systems that originate in the brainstem or hypothalamus, and project to subcortical and cortical sites. We discuss efforts to ...

journal_title：Current opinion in neurobiology

authors： Marrocco RT,Witte EA,Davidson MC

更新日期：1994-04-01 00:00:00

abstract：:The recent cloning of the gamma-aminobutyric acid and norepinephrine Na(+)-dependent neurotransmitter transporters has led to new approaches for understanding the structure and function of these important synaptic proteins and provides a conceptual model in which to consider recent advances in the physiology, pharmaco...

journal_title：Current opinion in neurobiology

authors： Amara SG,Pacholczyk T

更新日期：1991-06-01 00:00:00

abstract：:The striatum is a hub in the basal ganglia circuitry controlling goal directed actions and habits. The loss of its dopaminergic (DAergic) innervation in Parkinson's disease (PD) disrupts the ability of the two principal striatal projection systems to respond appropriately to cortical and thalamic signals, resulting in...

journal_title：Current opinion in neurobiology

authors： Zhai S,Tanimura A,Graves SM,Shen W,Surmeier DJ

更新日期：2018-02-01 00:00:00

abstract：:Axon pathfinding is essential for the establishment of proper neuronal connections during development. Advances in neuroimaging and genomic technologies, coupled with animal modeling, are leading to the identification of an increasing number of human disorders that result from aberrant axonal wiring. In this review, w...

journal_title：Current opinion in neurobiology

authors： Nugent AA,Kolpak AL,Engle EC

更新日期：2012-10-01 00:00:00