Abstract:
:Ionotropic AMPA-type glutamate receptors and G-protein-coupled metabotropic GABAB receptors are key elements of neurotransmission whose cellular functions are determined by their protein constituents. Over the past couple of years unbiased proteomic approaches identified comprehensive sets of protein building blocks of these two types of neurotransmitter receptors in the brain (termed receptor proteomes). This provided the opportunity to match receptor proteomes with receptor physiology and to study the structural organization, regulation and function of native receptor complexes in an unprecedented manner. In this review we discuss the principles of receptor architecture and regulation emerging from the functional characterization of the proteomes of AMPA and GABAB receptors. We also highlight progress in unraveling the role of unexpected protein components for receptor physiology.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Bettler B,Fakler Bdoi
10.1016/j.conb.2017.02.011subject
Has Abstractpub_date
2017-08-01 00:00:00pages
16-23eissn
0959-4388issn
1873-6882pii
S0959-4388(16)30230-6journal_volume
45pub_type
杂志文章,评审abstract::The behavioral repertoire of an organism can be highly diverse, spanning from social to defensive. How an animal efficiently switches between distinct behaviors is a fundamental question whose inquiry will provide insights into the mechanisms that are necessary for an organism's survival. Previous work aimed at identi...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2018.04.017
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abstract::In bilaterally symmetric organisms, the midline is a critical organizing center for the developing central nervous system. There is a striking conservation of the molecules and mechanisms that control axon path finding at the midline in vertebrate and invertebrate nervous systems. The majority of axons in the CNS cros...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2009.12.006
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2017.03.001
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journal_title:Current opinion in neurobiology
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doi:10.1016/j.conb.2019.01.014
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abstract::Social experiences throughout life influence gene expression and behavior, however, early in development these influences have a particularly profound effect. In mammals, mother-infant interactions are the primary source of social stimulation and result in long-term changes in offspring phenotype. This has previously ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2005.10.001
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abstract::Neurofilaments are proteins selectively expressed in the cytoskeleton of neurons, and increased levels are a marker of damage. Elevated neurofilament levels can serve as a marker of ongoing disease activity as well as a tool to measure response to therapeutic intervention. The potential utility of neurofilaments has d...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2020.02.001
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(00)00078-7
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(98)80071-8
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(02)00323-9
更新日期:2002-06-01 00:00:00
abstract::Neural oscillations are ubiquitous in olfactory systems of mammals, insects and molluscs. Neurophysiological and computational investigations point to common mechanisms for gamma or odor associated oscillations across phyla (40-100Hz in mammals, 20-30Hz in insects, 0.5-1.5Hz in molluscs), engaging the reciprocal dendr...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2014.10.004
更新日期:2015-04-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(02)00308-2
更新日期:2002-04-01 00:00:00
abstract::What I cannot create I do not understand - Richard Feynman 1978 Because primate cortical development exhibits numerous specific features, the mouse is an imperfect model for human cortical development. Expansion of supragranular neurons is an evolutionary feature characterizing the primate cortex. Increased production...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2020.09.012
更新日期:2020-10-21 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2011.10.011
更新日期:2012-04-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2010.09.013
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(00)00100-8
更新日期:2000-06-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2013.03.003
更新日期:2013-10-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2013.12.010
更新日期:2014-04-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2008.08.006
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2012.06.005
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2011.12.003
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abstract::MicroRNAs (miRNAs) are a recently discovered, extensive class of small noncoding RNAs that act as post-transcriptional regulators of gene expression. miRNAs have been implicated in most aspects of animal development and in pathological processes such as cancer. In neurons, miRNAs are expressed at all stages of develop...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2009.05.015
更新日期:2009-04-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2006.08.003
更新日期:2006-10-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2017.06.008
更新日期:2017-12-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2018.04.009
更新日期:2018-10-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2013.11.003
更新日期:2014-06-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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