Determinants of primate neurogenesis and the deployment of top-down generative networks in the cortical hierarchy.

abstract：:The precise causal factors for obsessive-compulsive disorder (OCD) are not known, although, decades of research have honed in on the cortico-striatal-thalamo-cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimately linked compulsive-repetitive behaviors. Recent progress in...

journal_title：Current opinion in neurobiology

authors： Ting JT,Feng G

更新日期：2011-12-01 00:00:00

abstract：:The plasticity of the nervous system is due to the ability of neurons to change their properties by altering the function of their proteome. A major mechanism for this is through altering the amount of proteins by regulating their translation. In this review, we focus on recent advances in the elucidation of the mecha...

journal_title：Current opinion in neurobiology

authors： Sossin WS,Lacaille JC

更新日期：2010-08-01 00:00:00

abstract：:The visual cortical network consists of a number of specialized areas that are connected in a highly structured way. Understanding the function of this network is a milestone goal of visual neuroscience. This goal is pursued at different levels of description, including large-scale neuroanatomical as well as molecular...

journal_title：Current opinion in neurobiology

authors： Katzner S,Weigelt S

更新日期：2013-04-01 00:00:00

abstract：:Cyclic AMP response element binding protein (CREB)-responsive transcription plays a central role in the formation of long-term memory in Drosophila, Aplysia and mice. Agents that disrupt the activity of CREB specifically block the formation of long-term memory, whereas agents that increase the amount or activity of th...

journal_title：Current opinion in neurobiology

authors： Yin JC,Tully T

更新日期：1996-04-01 00:00:00

abstract：:The striatum is a hub in the basal ganglia circuitry controlling goal directed actions and habits. The loss of its dopaminergic (DAergic) innervation in Parkinson's disease (PD) disrupts the ability of the two principal striatal projection systems to respond appropriately to cortical and thalamic signals, resulting in...

journal_title：Current opinion in neurobiology

authors： Zhai S,Tanimura A,Graves SM,Shen W,Surmeier DJ

更新日期：2018-02-01 00:00:00

abstract：:Neurons have a multiplicity of ionic conductance mechanisms, the interactions of which determine in part the response of a neuron to chemical and electrical synaptic interactions, firing patterns, excitability, membrane potential and action-potential waveform. Several papers published in the past year have provided im...

journal_title：Current opinion in neurobiology

authors： Baxter DA,Byrne JH

更新日期：1991-06-01 00:00:00

abstract：:Visual attention operates by biasing competitive interactions between neural representations, favoring relevant over irrelevant visual inputs. Attention can enhance the processing of relevant information using location-based, feature-based or object-based selection mechanisms. Studies using event-related potential and...

journal_title：Current opinion in neurobiology

authors： Hopf JM,Schoenfeld MA,Heinze HJ

更新日期：2005-04-01 00:00:00

abstract：:Chronic administration of opiates or cocaine has been shown to alter the activity or expression of diverse types of cellular proteins in specific target neurons within the central nervous system. Prominent examples include signaling proteins, such as receptors, G proteins, second-messenger synthetic enzymes, and prote...

journal_title：Current opinion in neurobiology

authors： Nestler EJ

更新日期：1997-10-01 00:00:00

abstract：:Parenting is essential for survival and wellbeing in many species. Since it can be performed with little prior experience and entails considerable sacrifices without immediate benefits for the caregiver, this behavior is likely orchestrated by evolutionarily shaped, hard-wired neural circuits. At the same time, experi...

journal_title：Current opinion in neurobiology

authors： Kohl J

更新日期：2020-02-01 00:00:00

abstract：:The search for quantifiable biological mediators of genetic risk or 'intermediate phenotypes' is an essential strategy in psychiatric neuroscience and a useful tool for exploring the complex relationships between genes, neural circuits and behaviors. In recent years, the examination of connectivity-based intermediate ...

journal_title：Current opinion in neurobiology

authors： Cao H,Dixson L,Meyer-Lindenberg A,Tost H

更新日期：2016-02-01 00:00:00

abstract：:Homeostatic synaptic plasticity remains an enigmatic form of synaptic plasticity. Increasing interest on the topic has fuelled a surge of recent studies that have identified key molecular players and the signaling pathways involved. However, the new findings also highlight our lack of knowledge concerning some of the ...

journal_title：Current opinion in neurobiology

authors： Vitureira N,Letellier M,Goda Y

更新日期：2012-06-01 00:00:00

abstract：:Recent findings suggest that cerebral laterality will not be understood in terms of simple dichotomies, such as the idea that the left hemisphere is analytic and the right holistic. Rather, hemisphere differences can be better explained in terms of relatively specific principles that extend over limited domains. For v...

journal_title：Current opinion in neurobiology

authors： Brown HD,Kosslyn SM

更新日期：1993-04-01 00:00:00

abstract：:Smooth-pursuit eye movements are used to stabilize the image of a moving object of interest on the fovea, thus guaranteeing its high-acuity scrutiny. Such movements are based on a phylogenetically recent cerebro-ponto-cerebellar pathway that has evolved in parallel with foveal vision. Recent work has shown that a netw...

journal_title：Current opinion in neurobiology

authors： Thier P,Ilg UJ

更新日期：2005-12-01 00:00:00

abstract：:Animal eyes have long served as a classical example of independent origin followed by convergence of structures onto a few different solutions. During the past decade this view has been challenged by the discovery of shared developmental regulatory genes. The Pax6 gene in particular is almost universally employed for ...

journal_title：Current opinion in neurobiology

authors： Nilsson DE

更新日期：2004-08-01 00:00:00

abstract：:'Auditory scenes' often contain contributions from multiple acoustic sources. These are usually heard as separate auditory 'streams', which can be selectively followed over time. How and where these auditory streams are formed in the auditory system is one of the most fascinating questions facing auditory scientists t...

journal_title：Current opinion in neurobiology

authors： Shamma SA,Micheyl C

更新日期：2010-06-01 00:00:00

abstract：:Dynamics of neuronal networks can be altered in at least two ways: by changes in connectivity, that is, the physical architecture of the network, or changes in the amplitudes and kinetics of the intrinsic and synaptic currents within and between the elements making up a network. We argue that the latter changes are of...

journal_title：Current opinion in neurobiology

authors： McCarthy MM,Ching S,Whittington MA,Kopell N

更新日期：2012-08-01 00:00:00

abstract：:One of the seminal discoveries in developmental neuroscience is that altering visual experience through monocular deprivation can alter both the physiological and the anatomical representation of the two eyes, called ocular dominance columns, in primary visual cortex. This rearrangement is restricted to a critical per...

journal_title：Current opinion in neurobiology

authors： Feller MB,Scanziani M

更新日期：2005-02-01 00:00:00

abstract：:For many years, it has been postulated that interactions between motor commands and somatic perception in the sensorimotor cortices exist, but they have been difficult to demonstrate. Recent studies have made demonstration of this interaction easier and suggest that cortical activity related to somatic sensation and p...

journal_title：Current opinion in neurobiology

authors： Nelson RJ

更新日期：1996-12-01 00:00:00

abstract：:This review focuses on the neurobiological processes involved in achieving successful abstinence from drugs of abuse. While there is clinical and public health value in knowing if the deficits associated with drug use correct with abstinence, studying the neurobiology that underlies successful abstinence can also illu...

journal_title：Current opinion in neurobiology

authors： Garavan H,Brennan KL,Hester R,Whelan R

更新日期：2013-08-01 00:00:00

abstract：:Müller Glia (MG), the radial glia cells of the retina, have spectacular morphologies subserving their enormous functional complexity. As early as 1892, the great neuroanatomist Santiago Ramon y Cajal studied the morphological development of MG, defining several steps in their morphogenesis [1,2]. However, the molecula...

journal_title：Current opinion in neurobiology

authors： MacDonald RB,Charlton-Perkins M,Harris WA

更新日期：2017-12-01 00:00:00

abstract：:Sex steroid hormones exert a profound influence on the sexual differentiation and function of the neural circuits that mediate dimorphic behaviors. Both estrogen and testosterone are essential for male typical behaviors in many species. Recent studies with genetically modified mice provide important new insights into ...

journal_title：Current opinion in neurobiology

authors： Wu MV,Shah NM

更新日期：2011-02-01 00:00:00

abstract：:The ability to make accurate predictions of future stimuli and consequences of one's actions are crucial for the survival and appropriate decision-making. These predictions are constantly being made at different levels of the nervous system. This is evidenced by adaptation to stimulus parameters in sensory coding, and...

journal_title：Current opinion in neurobiology

authors： Sharpee TO,Calhoun AJ,Chalasani SH

更新日期：2014-04-01 00:00:00

abstract：:Vestibulo-ocular reflexes (VOR) assist retinal image stabilization during vertebrate locomotion thereby ensuring accurate visual perception. The importance of this motor behavior for animal survival requires that the underlying circuitry and all individual components are fully developed and functional as soon as post-...

journal_title：Current opinion in neurobiology

authors： Straka H

更新日期：2010-12-01 00:00:00

abstract：:It is becoming evident that neurons express an unusual number of molecules that were originally thought to be specific to immune functions. One such molecule, class I major histocompatibility complex, is required in the activity-dependent refinement and plasticity of connections in the developing and adult central ner...

journal_title：Current opinion in neurobiology

authors： Boulanger LM,Huh GS,Shatz CJ

更新日期：2001-10-01 00:00:00

abstract：:Reward valuation in social contexts is by nature relative rather than absolute; it is made in reference to others. This socially relative reward valuation is based on our propensity to conduct comparisons and competitions between self and other. Exploring its neural substrate has been an active area of research in hum...

journal_title：Current opinion in neurobiology

authors： Isoda M

更新日期：2020-12-08 00:00:00

abstract：:This review covers the dynamic regulation of neuroligin isoforms, focusing on posttranslational events including phosphorylation, glycosylation and activity-dependent cleavage. There is a growing literature on how phosphorylation confers an isoform-specific level of modulation affecting a variety of protein interactio...

journal_title：Current opinion in neurobiology

authors： Jeong J,Paskus JD,Roche KW

更新日期：2017-08-01 00:00:00

abstract：:The gene product responsible for autosomal recessive juvenile Parkinsonism, Parkin, has been observed to have ubiquitin ligase activity. This finding has changed the direction of studies on Parkinson's disease by suggesting that abnormal protein turnover might be involved in its pathogenesis. A number of potentially n...

journal_title：Current opinion in neurobiology

authors： Imai Y,Takahashi R

更新日期：2004-06-01 00:00:00

abstract：:In the past year, our knowledge of neurotransmitter transporters has increased significantly. Recently, new members of two families of plasma membrane uptake carriers have been cloned, and the stoichiometries, physiological function and mechanisms of modulation of some of these transporters are now better understood. ...

journal_title：Current opinion in neurobiology

authors： Attwell D,Mobbs P

更新日期：1994-06-01 00:00:00

abstract：:Auditory cortical maps have been a long-standing focus of studies that assess the expression, mechanisms, and consequences of sensory plasticity. Here we discuss recent progress in understanding how auditory experience transforms spatially organized sound representations at higher levels of the central auditory pathwa...

journal_title：Current opinion in neurobiology

authors： Schreiner CE,Polley DB

更新日期：2014-02-01 00:00:00

abstract：:It is now 15 years since the discovery that N-methyl-d-aspartate receptor activity is required to maintain the refined topographic organization of retinotectal projections. Recent studies have identified additional components of the signaling pathways required for activity-dependent map formation and maintenance. Nitr...

journal_title：Current opinion in neurobiology

authors： Debski EA,Cline HT

更新日期：2002-02-01 00:00:00