Abstract:
:It is now 15 years since the discovery that N-methyl-d-aspartate receptor activity is required to maintain the refined topographic organization of retinotectal projections. Recent studies have identified additional components of the signaling pathways required for activity-dependent map formation and maintenance. Nitric oxide and brain-derived neurotrophic factor, candidate retrograde messengers, and serotonin and acetylcholine, modulators of neuronal excitability, all affect mapping. These studies indicate that the mapping process intersects with other processes fundamental to visual system development and function, such as process outgrowth, synaptic turnover and neuromodulation.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Debski EA,Cline HTdoi
10.1016/s0959-4388(02)00295-7subject
Has Abstractpub_date
2002-02-01 00:00:00pages
93-9issue
1eissn
0959-4388issn
1873-6882pii
S0959438802002957journal_volume
12pub_type
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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