Abstract:
:The gut microbiome - the largest reservoir of microorganisms of the human body - is emerging as an important player in neurodevelopment and ageing as well as in brain diseases including stroke, Alzheimer's disease and Parkinson's disease. The growing knowledge on mediators and triggered pathways has advanced our understanding of the interactions along the gut-brain axis. Gut bacteria produce neuroactive compounds and can modulate neuronal function, plasticity and behavior. Furthermore, intestinal microorganisms impact the host's metabolism and immune status which in turn affect neuronal pathways in the enteric and central nervous systems. Here, we discuss the recent insights from human studies and animal models on the bi-directional communication along the microbiome-gut-brain axis in both acute and chronic brain diseases.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Benakis C,Martin-Gallausiaux C,Trezzi JP,Melton P,Liesz A,Wilmes Pdoi
10.1016/j.conb.2019.11.009subject
Has Abstractpub_date
2020-04-01 00:00:00pages
1-9eissn
0959-4388issn
1873-6882pii
S0959-4388(19)30108-4journal_volume
61pub_type
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