Abstract:
:Neocortex expansion in development and evolution reflects an increased and prolonged activity of neural progenitor cells. Insight into key aspects of the underlying cell biology has recently been obtained. First, the restriction of apical progenitors to undergo mitosis at the ventricular surface is overcome by generation of basal progenitors, which are free to undergo mitosis at abventricular location, typically the subventricular zone. This process involves basolateral ciliogenesis, delamination from the apical adherens junction belt, and loss of apical cell polarity. Second, proliferative capacity of basal progenitors is supported by self-produced extracellular matrix constituents, which in turn promote growth factor signalling. Humans amplify these processes by characteristic alterations in expression of key regulatory genes (PAX6), and via human-specific genes (ARHGAP11B).
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Wilsch-Bräuninger M,Florio M,Huttner WBdoi
10.1016/j.conb.2016.05.004subject
Has Abstractpub_date
2016-08-01 00:00:00pages
122-32eissn
0959-4388issn
1873-6882pii
S0959-4388(16)30055-1journal_volume
39pub_type
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