Abstract:
:Recent studies suggest that endocannabinoids act as retrograde messengers at many synapses in the central nervous system. Activation of phospholipases, either through calcium-mediated or receptor-mediated signaling, leads to the formation and release of endocannabinoids. These lipophilic signaling molecules diffuse to nearby presynaptic terminals where they bind to specific G-protein-coupled receptors and inhibit neurotransmitter release for tens of seconds. Thus, an important physiological role of endocannabinoids may be to provide a mechanism by which neurons can rapidly regulate the strength of their synaptic inputs.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Kreitzer AC,Regehr WGdoi
10.1016/s0959-4388(02)00328-8subject
Has Abstractpub_date
2002-06-01 00:00:00pages
324-30issue
3eissn
0959-4388issn
1873-6882pii
S0959438802003288journal_volume
12pub_type
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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