The neural circuits of thermal perception.


:Thermal information about skin surface temperature is a key sense for the perception of object identity and valence. The identification of ion channels involved in the transduction of thermal changes has provided a genetic access point to the thermal system. However, from sensory specific 'labeled-lines' to multimodal interactive pathways, the functional organization and identity of the neural circuits mediating innocuous thermal perception have been debated for over 100 years. Here we highlight points in the system that require further attention and review recent advances using in vivo electrophysiology, cellular resolution calcium imaging, optogenetics and thermal perceptual tasks in behaving mice that have begun to uncover the anatomical principles and neural processing mechanisms underlying innocuous thermal perception.


Curr Opin Neurobiol


Bokiniec P,Zampieri N,Lewin GR,Poulet JF




Has Abstract


2018-10-01 00:00:00












  • Cellular mechanisms of long-term depression in the cerebellum.

    abstract::Cerebellar long-term depression is a persistent, input-specific attenuation of the parallel fiber-Purkinje neuron synapse induced by co-activation of parallel fibers and climbing fibers. This phenomenon endows the Purkinje neuron with a powerful associative computational ability. Recent investigations have provided st...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Linden DJ,Connor JA

    更新日期:1993-06-01 00:00:00

  • Glial regulation of the axonal membrane at nodes of Ranvier.

    abstract::Action potential conduction in myelinated nerve fibers depends on a polarized axonal membrane. Voltage-gated Na(+) and K(+) channels are clustered at nodes of Ranvier and mediate the transmembrane currents necessary for rapid saltatory conduction. Paranodal junctions flank nodes and function as attachment sites for my...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Schafer DP,Rasband MN

    更新日期:2006-10-01 00:00:00

  • Mechanisms of neurite repair.

    abstract::Upon receiving injury signals, neurons can activate various pathways to reduce harm, initiate neuroprotection, and repair damaged neurite without cell death. Here, we review recent progresses in the study of neurite repair focusing on neuronal cell-autonomous mechanisms, including new findings on ion channels that ser...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Liu HH,Jan YN

    更新日期:2020-08-01 00:00:00

  • Ankyrins and neurological disease.

    abstract::Ankyrins are scaffolding proteins widely expressed throughout the nervous system. Ankyrins recruit diverse membrane proteins, including ion channels and cell adhesion molecules, into specialized subcellular membrane domains. These domains are stabilized by ankyrins interacting with the spectrin cytoskeleton. Ankyrin g...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Stevens SR,Rasband MN

    更新日期:2021-01-20 00:00:00

  • The evolution of neuronal circuits underlying species-specific behavior.

    abstract::The nervous system is evolutionarily conservative compared to the peripheral appendages that it controls. However, species-specific behaviors may have arisen from very small changes in neuronal circuits. In particular, changes in neuromodulatory systems may allow multifunctional circuits to produce different sets of b...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Katz PS,Harris-Warrick RM

    更新日期:1999-10-01 00:00:00

  • Local aspects of sleep and wakefulness.

    abstract::Slow waves, the hallmark of NREM (Non Rapid Eye Movement) sleep, are not uniformly distributed across the cortical surface, but can occur locally and asynchronously across brain regions. Their regional distribution and amplitude is affected by brain maturation and by time spent awake, mediated in part by experience-de...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Siclari F,Tononi G

    更新日期:2017-06-01 00:00:00

  • The dynamic cytoskeleton: backbone of dendritic spine plasticity.

    abstract::Dendritic spines are small actin-rich protrusions on the surface of dendrites whose morphological and molecular plasticity play key roles in learning and memory. Both the form and function of spines are critically dependent on the actin cytoskeleton. However, new research, using electron microscopy and live-cell super...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Dent EW,Merriam EB,Hu X

    更新日期:2011-02-01 00:00:00

  • Rhythms of behavior: are the times changin'?

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    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Häfker NS,Tessmar-Raible K

    更新日期:2020-02-01 00:00:00

  • The temporal flexibility of attentional selection in the visual cortex.

    abstract::Visual attention operates by biasing competitive interactions between neural representations, favoring relevant over irrelevant visual inputs. Attention can enhance the processing of relevant information using location-based, feature-based or object-based selection mechanisms. Studies using event-related potential and...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Hopf JM,Schoenfeld MA,Heinze HJ

    更新日期:2005-04-01 00:00:00

  • Identifying behavioral circuits in Drosophila melanogaster: moving targets in a flying insect.

    abstract::Drosophila melanogaster has historically been the premier model system for understanding the molecular and genetic bases of complex behaviors. In the last decade technical advances, in the form of new genetic tools and electrophysiological and optical methods, have allowed investigators to begin to dissect the neurona...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Griffith LC

    更新日期:2012-08-01 00:00:00

  • Alternative conceptions of memory consolidation and the role of the hippocampus at the systems level in rodents.

    abstract::We discuss very recent experiments with rodents addressing the idea that long-term memories initially depending on the hippocampus, over a prolonged period, become independent of it. No unambiguous recent evidence exists to substantiate that this occurs. Most experiments find that recent and remote memories are equall...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章


    authors: Sutherland RJ,Lehmann H

    更新日期:2011-06-01 00:00:00

  • Bayesian statistics: relevant for the brain?

    abstract::Analyzing data from experiments involves variables that we neuroscientists are uncertain about. Efficiently calculating with such variables usually requires Bayesian statistics. As it is crucial when analyzing complex data, it seems natural that the brain would "use" such statistics to analyze data from the world. And...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Kording KP

    更新日期:2014-04-01 00:00:00

  • Vascular regulation of glioma stem-like cells: a balancing act.

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    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Brooks LJ,Parrinello S

    更新日期:2017-12-01 00:00:00

  • Modeling human neuronal migration deficits in 3D.

    abstract::During the past few decades, we have witnessed an impressive gain in the knowledge regarding the basic mechanisms underlying human neuronal migration disorders by the usage of mouse models. Nevertheless, despite the remarkable conservation both in the genetic encoded information and the developmental processes, there ...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Reiner O,Parichha A,Sapir T

    更新日期:2020-10-15 00:00:00

  • Local protein synthesis during axon guidance and synaptic plasticity.

    abstract::mRNA localization and regulated translation take central roles in axon guidance and synaptic plasticity. By spatially restricting gene expression within neurons, local protein synthesis provides growth cones and synapses with the capacity to autonomously regulate their structure and function. Studies in a variety of s...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Martin KC

    更新日期:2004-06-01 00:00:00

  • Advanced optical imaging techniques for neurodevelopment.

    abstract::Over the past decade, developmental neuroscience has been transformed by the widespread application of confocal and two-photon fluorescence microscopy. Even greater progress is imminent, as recent innovations in microscopy now enable imaging with increased depth, speed, and spatial resolution; reduced phototoxicity; a...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Wu Y,Christensen R,Colón-Ramos D,Shroff H

    更新日期:2013-12-01 00:00:00

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    abstract::Auditory cortical maps have been a long-standing focus of studies that assess the expression, mechanisms, and consequences of sensory plasticity. Here we discuss recent progress in understanding how auditory experience transforms spatially organized sound representations at higher levels of the central auditory pathwa...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Schreiner CE,Polley DB

    更新日期:2014-02-01 00:00:00

  • A matter of focus: monoaminergic modulation of stimulus coding in mammalian sensory networks.

    abstract::Although the presence of neuromodulators in mammalian sensory systems has been noted for some time, a groundswell of evidence has now begun to document the scope of these regulatory mechanisms in several sensory systems, highlighting the importance of neuromodulation in shaping feature extraction at all levels of neur...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Hurley LM,Devilbiss DM,Waterhouse BD

    更新日期:2004-08-01 00:00:00

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    abstract::The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN i...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Backman S,Stambolic V,Mak T

    更新日期:2002-10-01 00:00:00

  • Autophagy in the presynaptic compartment.

    abstract::Regulated release of neurotransmitter depends on the orchestrated function of a large number of proteins in the presynaptic compartment. When synaptic vesicles fuse with the plasma membrane, these membranes and the attached proteins are endocytosed and either recycled or degraded. This turnover needs to be tightly reg...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Lüningschrör P,Sendtner M

    更新日期:2018-08-01 00:00:00

  • Socially relative reward valuation in the primate brain.

    abstract::Reward valuation in social contexts is by nature relative rather than absolute; it is made in reference to others. This socially relative reward valuation is based on our propensity to conduct comparisons and competitions between self and other. Exploring its neural substrate has been an active area of research in hum...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Isoda M

    更新日期:2020-12-08 00:00:00

  • Neurofilaments in disease: what do we know?

    abstract::Neurofilaments are proteins selectively expressed in the cytoskeleton of neurons, and increased levels are a marker of damage. Elevated neurofilament levels can serve as a marker of ongoing disease activity as well as a tool to measure response to therapeutic intervention. The potential utility of neurofilaments has d...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Gordon BA

    更新日期:2020-04-01 00:00:00

  • Endocannabinoid system and drug addiction: new insights from mutant mice approaches.

    abstract::The involvement of the endocannabinoid system in drug addiction was initially studied by the use of compounds with different affinities for each cannabinoid receptor or for the proteins involved in endocannabinoids inactivation. The generation of genetically modified mice with selective mutations in these endocannabin...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章


    authors: Maldonado R,Robledo P,Berrendero F

    更新日期:2013-08-01 00:00:00

  • Survival factors in retinal degenerations.

    abstract::Recent experiments on the retina have examined the effectiveness of various factors (e.g. growth factors, neurotrophins and cytokines) for enhancing survival and reducing injury of retinal neurons, such as photoreceptors and ganglion cells, whose death leads to blindness in degenerative retinal diseases. It has also b...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Steinberg RH

    更新日期:1994-08-01 00:00:00

  • Myelin-associated glycoprotein: a role in myelination and in the inhibition of axonal regeneration?

    abstract::Inhibitory molecules in CNS myelin affect axonal regeneration after injury. In the past year, myelin-associated glycoprotein (MAG), a well-characterized myelin protein, has been identified as an inhibitor of axonal regeneration. This finding, together with its established ability to promote outgrowth, defines MAG as a...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Filbin MT

    更新日期:1995-10-01 00:00:00

  • The determination of projection neuron identity in the developing cerebral cortex.

    abstract::Here we review the mechanisms that determine projection neuron identity during cortical development. Pyramidal neurons in the mammalian cerebral cortex can be classified into two major classes: corticocortical projection neurons, which are concentrated in the upper layers of the cortex, and subcortical projection neur...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Leone DP,Srinivasan K,Chen B,Alcamo E,McConnell SK

    更新日期:2008-02-01 00:00:00

  • Stimulating neurons with light.

    abstract::Recent technological advances have enabled the use of different optical methods to activate neurons, including 'caged' glutamate, photoactivation of genetically engineered cascades, and direct two-photon excitation. The ability to use light as a stimulation tool provides, in principle, a non-invasive method for the te...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Callaway EM,Yuste R

    更新日期:2002-10-01 00:00:00

  • Cell death and sexual differentiation of behavior: worms, flies, and mammals.

    abstract::Sex differences in the nervous system are found throughout the animal kingdom. Here, we discuss three prominent genetic models: nematodes, fruit flies, and mice. In all three, differential cell death is central to sexual differentiation and shared molecular mechanisms have been identified. Our knowledge of the precise...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Forger NG,de Vries GJ

    更新日期:2010-12-01 00:00:00

  • Myelin plasticity and behaviour-connecting the dots.

    abstract::Myelin sheaths in the vertebrate nervous system enable faster impulse propagation, while myelinating glia provide vital support to axons. Once considered a static insulator, converging evidence now suggests that myelin in the central nervous system can be dynamically regulated by neuronal activity and continues to par...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Kaller MS,Lazari A,Blanco-Duque C,Sampaio-Baptista C,Johansen-Berg H

    更新日期:2017-12-01 00:00:00

  • Schizophrenia and cognitive function.

    abstract::Schizophrenia is often associated with cognitive deficits, particularly within the domains of memory and language. Specific cognitive deficits have recently been linked to psychotic phenomena, including verbal hallucinations and disorganized speech. Impairments of working and semantic memory are primarily due to dysfu...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Kuperberg G,Heckers S

    更新日期:2000-04-01 00:00:00