The neural circuits of thermal perception.

abstract：:The involvement of the endocannabinoid system in drug addiction was initially studied by the use of compounds with different affinities for each cannabinoid receptor or for the proteins involved in endocannabinoids inactivation. The generation of genetically modified mice with selective mutations in these endocannabin...

journal_title：Current opinion in neurobiology

authors： Maldonado R,Robledo P,Berrendero F

更新日期：2013-08-01 00:00:00

abstract：:Neurons utilize mRNA transport and local translation as a means to influence development and plasticity. The molecular mechanisms for this mRNA sorting involve the recognition of cis-acting sequences by distinct mRNA binding proteins that have a dual role, acting in both mRNA transport and translational regulation. Ot...

journal_title：Current opinion in neurobiology

authors： Bassell GJ,Kelic S

更新日期：2004-10-01 00:00:00

abstract：:Phototransduction in Drosophila's microvillar photoreceptors is mediated by phospholipase C (PLC) resulting in activation of two distinct Ca(2+)-permeable channels, TRP and TRPL. Here we review recent evidence on the unresolved mechanism of their activation, including the hypothesis that the channels are mechanically ...

journal_title：Current opinion in neurobiology

authors： Hardie RC,Juusola M

更新日期：2015-10-01 00:00:00

abstract：:Activity in cortical networks is heterogeneous, sparse and often precisely timed. The functional significance of sparseness and precise spike timing is debated, but our understanding of the developmental and synaptic mechanisms that shape neuronal discharge patterns has improved. Evidence for highly specialized, selec...

journal_title：Current opinion in neurobiology

authors： Wolfe J,Houweling AR,Brecht M

更新日期：2010-06-01 00:00:00

abstract：:Recent studies show that anatomical and functional brain networks exhibit similar small-world properties. However, the networks that are compared often differ in what the nodes represent (e.g. sensors or brain areas), what kind of connectivity is measured, and what temporal and spatial scales are probed. Here, I revie...

journal_title：Current opinion in neurobiology

authors： Ioannides AA

更新日期：2007-04-01 00:00:00

abstract：:Standard economic theories conceive homo economicus as a rational decision maker capable of maximizing utility. In reality, however, people tend to approximate optimal decision-making strategies through a collection of heuristic routines. Some of these routines are driven by emotional processes, and others are adjuste...

journal_title：Current opinion in neurobiology

authors： Lee D

更新日期：2006-04-01 00:00:00

abstract：:Accepting, rejecting or modifying the many different theories of the cerebellum's role in the control of movement requires an understanding of the signals encoded in the discharge of cerebellar neurons and how those signals are transformed by the cerebellar circuitry. Particularly challenging is understanding the sens...

journal_title：Current opinion in neurobiology

authors： Ebner TJ

更新日期：1998-12-01 00:00:00

abstract：:Most high-level sensory neurons have complex, nonlinear response properties; a comprehensive characterization of these properties remains a formidable challenge. Recent studies using complex sensory stimuli combined with linear and nonlinear analyses have provided new insights into the neuronal response properties in ...

journal_title：Current opinion in neurobiology

authors： Touryan J,Dan Y

更新日期：2001-08-01 00:00:00

abstract：:Developing axons appear to navigate to their targets partly in response to long-range diffusible chemoattractants secreted by target cells. The past year has seen the identification of the first target-derived attractants for developing axons, the netrins. Target-derived diffusible factors have also been implicated in...

journal_title：Current opinion in neurobiology

authors： Kennedy TE,Tessier-Lavigne M

更新日期：1995-02-01 00:00:00

abstract：:Vestibulo-ocular reflexes (VOR) assist retinal image stabilization during vertebrate locomotion thereby ensuring accurate visual perception. The importance of this motor behavior for animal survival requires that the underlying circuitry and all individual components are fully developed and functional as soon as post-...

journal_title：Current opinion in neurobiology

authors： Straka H

更新日期：2010-12-01 00:00:00

abstract：:In the past five years, the surrounding of the brain, that is the meninges (singular meninx) have evolved from being a physical barrier that protects the brain parenchyma to becoming a central player for both the maintenance of normal brain function and the modulation of neurological disorders. Indeed, the meninges ar...

journal_title：Current opinion in neurobiology

authors： Frederick N,Louveau A

更新日期：2020-06-01 00:00:00

abstract：:Sensory gating mechanisms are deployed during vertebrate locomotion to ensure that adaptive and appropriate motor responses to afferent input occur during all phases of the movement cycle. Recent animal studies on the integration of cutaneous information have investigated the roles of interneurones in sensory gating. ...

journal_title：Current opinion in neurobiology

authors： Sillar KT

更新日期：1991-12-01 00:00:00

abstract：:Human children benefit from a possibly unique set of adaptations facilitating the acquisition of knowledge about material culture. They represent artifacts (human-made objects) as tools with specific functions and seek for functional information about novel objects. Even young infants pay attention to functionally rel...

journal_title：Current opinion in neurobiology

authors： Hernik M,Csibra G

更新日期：2009-02-01 00:00:00

abstract：:Recent findings suggest that cerebral laterality will not be understood in terms of simple dichotomies, such as the idea that the left hemisphere is analytic and the right holistic. Rather, hemisphere differences can be better explained in terms of relatively specific principles that extend over limited domains. For v...

journal_title：Current opinion in neurobiology

authors： Brown HD,Kosslyn SM

更新日期：1993-04-01 00:00:00

abstract：:Synapses are specialized sites of cell contact that mediate information flow between neurons and their targets. Genetic screens in the nematode C. elegans have led to the discovery of a number of molecules required for synapse patterning and assembly. Recent studies have demonstrated the importance of guidepost cells ...

journal_title：Current opinion in neurobiology

authors： Margeta MA,Shen K,Grill B

更新日期：2008-02-01 00:00:00

abstract：:One of the seminal discoveries in developmental neuroscience is that altering visual experience through monocular deprivation can alter both the physiological and the anatomical representation of the two eyes, called ocular dominance columns, in primary visual cortex. This rearrangement is restricted to a critical per...

journal_title：Current opinion in neurobiology

authors： Feller MB,Scanziani M

更新日期：2005-02-01 00:00:00

abstract：:The development of motor behaviour depends on the differentiation of underlying circuitry. Recent work with the zebrafish brings the simple swimming behaviour of lower vertebrates and their embryos into focus as a suitable model to study the development of motor circuitry and its genetic control. Changes in connectivi...

journal_title：Current opinion in neurobiology

authors： Bate M

更新日期：1999-12-01 00:00:00

abstract：:Recent work on the retinotectal projection clearly establishes the roles of neuronal activity and position-based cues in the patterning of nerve connections. In some species, the high degree of spatial order has been shown to emerge from a continued process of terminal growth and refinement. The future challenge is no...

journal_title：Current opinion in neurobiology

authors： Fraser SE

更新日期：1992-02-01 00:00:00

abstract：:In order to understand how brain activity produces adaptive behavior we need large-scale, high-resolution recordings of neuronal activity. Fluorescent genetically encoded voltage indicators (GEVIs) offer the potential for these recordings to be performed chronically from targeted cells in a minimally invasive manner. ...

journal_title：Current opinion in neurobiology

authors： Platisa J,Pieribone VA

更新日期：2018-06-01 00:00:00

abstract：:The view of cerebellar functions has been extended from controlling sensorimotor processes to processing 'contextual' information and generating predictions for a diverse range of behaviors. These functions rely on the computation of the local cerebellar microcircuits and long-range connectivity that relays cerebellar...

journal_title：Current opinion in neurobiology

authors： Xiao L,Scheiffele P

更新日期：2018-02-01 00:00:00

abstract：:For many years pathophysiological studies on patients with movement disorders were viewed as inferior to those in animal models because, given the complexity of dealing with the complete interconnected CNS, it was difficult to assign any particular physiological abnormality exclusively to the site of a known lesion. M...

journal_title：Current opinion in neurobiology

authors： Rothwell JC,Huang YZ

更新日期：2003-12-01 00:00:00

abstract：:Chronic administration of opiates or cocaine has been shown to alter the activity or expression of diverse types of cellular proteins in specific target neurons within the central nervous system. Prominent examples include signaling proteins, such as receptors, G proteins, second-messenger synthetic enzymes, and prote...

journal_title：Current opinion in neurobiology

authors： Nestler EJ

更新日期：1997-10-01 00:00:00

abstract：:The polarity of neurotransmission mediated by the gamma-amino butyric acid (GABA) type A receptor depends crucially on intracellular chloride concentration, which is largely determined by the expression and function of cation/chloride co-transporters. Recent evidence shows how both activity and neurotrophic factors ca...

journal_title：Current opinion in neurobiology

authors： Fiumelli H,Woodin MA

更新日期：2007-02-01 00:00:00

abstract：:Central pattern generators are subject to extensive modulation that generates flexibility in the rhythmic outputs of these neural networks. The effects of neuromodulators interact with one another, and modulatory neurons are themselves often subject to modulation, enabling both higher order control and indirect intera...

journal_title：Current opinion in neurobiology

authors： Dickinson PS

更新日期：2006-12-01 00:00:00

abstract：:Neocortex expansion in development and evolution reflects an increased and prolonged activity of neural progenitor cells. Insight into key aspects of the underlying cell biology has recently been obtained. First, the restriction of apical progenitors to undergo mitosis at the ventricular surface is overcome by generat...

journal_title：Current opinion in neurobiology

authors： Wilsch-Bräuninger M,Florio M,Huttner WB

更新日期：2016-08-01 00:00:00

abstract：:Recent technological advances have enabled the use of different optical methods to activate neurons, including 'caged' glutamate, photoactivation of genetically engineered cascades, and direct two-photon excitation. The ability to use light as a stimulation tool provides, in principle, a non-invasive method for the te...

journal_title：Current opinion in neurobiology

authors： Callaway EM,Yuste R

更新日期：2002-10-01 00:00:00

abstract：:Over the years Pavlovian fear conditioning has proved to be a powerful model to investigate the neural underpinnings of aversive associative memory formation. Although it is well appreciated that plasticity occurring at excitatory synapses within the basolateral complex of the amygdala (BLA) plays a critical role in a...

journal_title：Current opinion in neurobiology

authors： Ressler RL,Maren S

更新日期：2019-02-01 00:00:00

abstract：:Cellular processes that mediate learning and memory show a remarkable level of conservation between vertebrates and invertebrates. Recent studies have shown that learning and memory formation in invertebrates, so-called 'simple systems', involves a highly complex arrangement of cellular pathways. Some pathways contrib...

journal_title：Current opinion in neurobiology

authors： Burrell BD,Sahley CL

更新日期：2001-12-01 00:00:00

abstract：:Neuroscience research has become increasingly reliant upon quantitative and computational data analysis and modeling techniques. However, the vast majority of neuroscientists are still trained within the traditional biology curriculum, in which computational and quantitative approaches beyond elementary statistics may...

journal_title：Current opinion in neurobiology

authors： Goldman MS,Fee MS

更新日期：2017-10-01 00:00:00

abstract：:Neurons have a multiplicity of ionic conductance mechanisms, the interactions of which determine in part the response of a neuron to chemical and electrical synaptic interactions, firing patterns, excitability, membrane potential and action-potential waveform. Several papers published in the past year have provided im...

journal_title：Current opinion in neurobiology

authors： Baxter DA,Byrne JH

更新日期：1991-06-01 00:00:00