Abstract:
:The view of cerebellar functions has been extended from controlling sensorimotor processes to processing 'contextual' information and generating predictions for a diverse range of behaviors. These functions rely on the computation of the local cerebellar microcircuits and long-range connectivity that relays cerebellar output to various brain areas. In this review, we discuss recent work on two of the circuit elements, which are thought to be fundamental for a wide range of non-sensorimotor behaviors: The role for cerebellar granule cells in multimodal integration in the cerebellar cortex and the long-range connectivity between the deep cerebellar nuclei and the basal ganglia. Lastly, we discuss how studies on synapses and circuits of the cerebellum in rodent models of autism-spectrum disorders might contribute to our understanding of the pathophysiology of this class of neurodevelopmental disorders.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Xiao L,Scheiffele Pdoi
10.1016/j.conb.2017.12.016subject
Has Abstractpub_date
2018-02-01 00:00:00pages
146-152eissn
0959-4388issn
1873-6882pii
S0959-4388(17)30204-0journal_volume
48pub_type
杂志文章,评审abstract::Neurons utilize mRNA transport and local translation as a means to influence development and plasticity. The molecular mechanisms for this mRNA sorting involve the recognition of cis-acting sequences by distinct mRNA binding proteins that have a dual role, acting in both mRNA transport and translational regulation. Ot...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2004.08.010
更新日期:2004-10-01 00:00:00
abstract::Processing of auditory information requires constant adjustment due to alterations of the environment and changing conditions in the nervous system with age, health, and experience. Consequently, patterns of activity in cortical networks have complex dynamics over a wide range of timescales, from milliseconds to days ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2015.10.003
更新日期:2015-12-01 00:00:00
abstract::It is now 15 years since the discovery that N-methyl-d-aspartate receptor activity is required to maintain the refined topographic organization of retinotectal projections. Recent studies have identified additional components of the signaling pathways required for activity-dependent map formation and maintenance. Nitr...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(02)00295-7
更新日期:2002-02-01 00:00:00
abstract::General anesthesia is a man-made neurophysiological state comprised of unconsciousness, amnesia, analgesia, and immobility along with maintenance of physiological stability. Growing evidence suggests that anesthetic-induced neural oscillations are a primary mechanism of anesthetic action. Each anesthetic drug class pr...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2017.04.011
更新日期:2017-06-01 00:00:00
abstract::High densities of acetylcholine receptors and sodium channels in the crests and troughs of the postsynaptic folds, respectively, ensure reliable neuromuscular signalling. Clustering of both ion channels is mediated by agrin. In the case of acetylcholine receptors, agrin activates the tyrosine kinase receptor muscle-sp...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(98)80061-5
更新日期:1998-06-01 00:00:00
abstract::Recent work has helped reconcile puzzling results from brainstem transection studies first performed over 60 years ago, which suggested the existence of a sleep-promoting system in the medullary brainstem. It was specifically shown that GABAergic neurons located in the medullary brainstem parafacial zone (PZGABA) are ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2017.04.004
更新日期:2017-06-01 00:00:00
abstract::Developing axons appear to navigate to their targets partly in response to long-range diffusible chemoattractants secreted by target cells. The past year has seen the identification of the first target-derived attractants for developing axons, the netrins. Target-derived diffusible factors have also been implicated in...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(95)80091-3
更新日期:1995-02-01 00:00:00
abstract::Schizophrenia is a disorder of cognitive neurodevelopment. At least some of the core cognitive deficits of the illness appear to be the product of impaired gamma frequency oscillations which depend, in part, on the inhibitory actions of a subpopulation of cortical GABA neurons that express the calcium binding protein ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2013.11.003
更新日期:2014-06-01 00:00:00
abstract::All animals have a fundamental and unavoidable requirement for rest, yet we still do not fully understand the processes that initiate, maintain, and regulate sleep. The larval zebrafish is an optically translucent, genetically tractable model organism that exhibits sleep states regulated by conserved sleep circuits, t...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2017.02.009
更新日期:2017-06-01 00:00:00
abstract::Neuroepithelial cells, the progenitors to the CNS neurons and glia, undergo both symmetric and asymmetric divisions. Symmetric divisions underlie the proliferation of neuroepithelial cells that predominates early in CNS development. Asymmetric divisions are thought to generate the cell types derived from neuroepitheli...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(97)80117-1
更新日期:1997-02-01 00:00:00
abstract::The rapid accumulation of neuroproteomics data in recent years has prompted the emergence of novel antibody-based imaging methods that aim to understand the anatomical and functional context of the multitude of identified proteins. The pioneering field of ultrastructural multiplexed proteomic imaging now includes a nu...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2011.08.004
更新日期:2012-02-01 00:00:00
abstract::GABAergic interneurons in the hippocampus coordinate neuronal activity that gives rise to network oscillations. In this article we present advances in our understanding of how different classes of hippocampal interneurons contribute to distinct hippocampal network oscillations. We focus on two main experimental approa...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2014.08.016
更新日期:2015-04-01 00:00:00
abstract::The investigation of mechanosensory feedback to locomotion has been hindered by the challenge of recording neurons in motion. Genetic accessibility and optical transparency of zebrafish larvae provide means to revisit this question. Glutamatergic Rohon-Beard (RB) and GABAergic CSF-contacting neurons (CSF-cNs) are spin...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2018.04.010
更新日期:2018-10-01 00:00:00
abstract::Sound is encoded by spiral ganglion neurons (SGNs) in the hearing organ, the cochlea, with great temporal, spectral and intensity resolution. When hearing fails, electric stimulation by implanted prostheses can partially restore hearing. Optical stimulation promises a fundamental advance of hearing restoration over el...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2015.01.004
更新日期:2015-10-01 00:00:00
abstract::Proteoglycans are ubiquitous cell-surface and secreted glycoproteins that are involved in diverse cellular behaviors. The identities of several nervous system proteoglycans, including many of the major species in the mammalian brain, have recently come to light. In addition, recent studies have given new insights into...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(93)90143-m
更新日期:1993-10-01 00:00:00
abstract::Biochemical and physiological evidence has suggested that myosins, both conventional and unconventional, are critical for neurosensory activities. In the past few years, this premise has been supported by genetic evidence that has shown that unconventional myosins are essential for the proper functioning of neurons, r...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(97)80080-3
更新日期:1997-10-01 00:00:00
abstract::Though many neuronal cell fate decisions result in reproducible outcomes, stochastic choices often lead to spatial randomization of cell subtypes. This is often the case in sensory systems where expression of a specific sensory receptor gene is selected randomly from a set of possible outcomes. Here, we describe recen...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2008.04.004
更新日期:2008-02-01 00:00:00
abstract::Vision is an active process. What we perceive strongly depends on our actions, intentions and expectations. During visual processing, these internal signals therefore need to be integrated with the visual information from the retina. The mechanisms of how this is achieved by the visual system are still poorly understo...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2018.05.003
更新日期:2018-10-01 00:00:00
abstract::Vocalizations transmit information to social partners, and mice use these signals to exchange information during courtship. Ultrasonic vocalizations from adult males are tightly associated with their interactions with females, and vary as a function of male quality. Work in the last decade has established that the spe...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2015.12.009
更新日期:2016-06-01 00:00:00
abstract::Genetic approaches at the neuromuscular synapse are leading investigation into the mechanisms of synaptogenesis. The marriage of classical (forward) and reverse genetic techniques allows the isolation and analysis of novel proteins involved in synaptic maturation and the functional in vivo characterization of previous...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(98)80016-0
更新日期:1998-02-01 00:00:00
abstract::A recent flurry of genetic studies in mice have provided key insights into how the somatosensory system is organized at a cellular level to encode itch, pain, temperature, and touch. These studies are largely predicated on the idea that functional cell types can be identified by their unique developmental provenance a...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2019.03.002
更新日期:2019-06-01 00:00:00
abstract::Recent functional brain imaging studies of the neurobiology of emotion have investigated how individual differences among subjects modulate neural responses during emotion processing. Differences in personality, dispositional affect, biological sex, and genotype can all substantially modulate the neural bases of emoti...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2004.03.010
更新日期:2004-04-01 00:00:00
abstract::The development of increasingly sophisticated methods for recording and manipulating neural activity is revolutionizing neuroscience. By probing how activity patterns in different types of neurons and circuits contribute to behavior, these tools can help inform mechanistic models of brain function and explain the role...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2018.01.004
更新日期:2018-04-01 00:00:00
abstract::Because of new data, anatomical and functional models of the basal ganglia in normal and pathological conditions (e.g. Parkinson's and Huntington's diseases) have recently come under greater scrutiny. An update of these models is clearly timely, taking into consideration not only changes in neuronal discharge rates, b...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(96)80024-9
更新日期:1996-12-01 00:00:00
abstract::The visual cortical network consists of a number of specialized areas that are connected in a highly structured way. Understanding the function of this network is a milestone goal of visual neuroscience. This goal is pursued at different levels of description, including large-scale neuroanatomical as well as molecular...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2013.01.019
更新日期:2013-04-01 00:00:00
abstract::Echolocating bats exhibit accurate three-dimensional (3D) auditory localization to avoid obstacles and intercept prey. The bat achieves high spatial resolution through a biological sonar system. Key features of the bat's sonar system are (1) high frequency, directional echolocation signals; (2) high frequency hearing;...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2016.08.002
更新日期:2016-12-01 00:00:00
abstract::The lateral line system is simple (comprising six cell types), its sense organs form according to a defined and reproducible pattern, and its neurons are easily visualized. In the zebrafish, these advantages can be combined with a wealth of genetic tools, making this system ideally suited to a combined molecular, cell...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2004.01.012
更新日期:2004-02-01 00:00:00
abstract::Rett syndrome (RTT) is one of the most common causes of intellectual and developmental disabilities in girls, and is caused by mutations in the gene encoding methyl-CpG binding protein 2 (MECP2). Here we will review our current understanding of RTT, the landscape of pathogenic mutations and function of MeCP2, and culm...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2019.08.001
更新日期:2019-12-01 00:00:00
abstract::'Auditory scenes' often contain contributions from multiple acoustic sources. These are usually heard as separate auditory 'streams', which can be selectively followed over time. How and where these auditory streams are formed in the auditory system is one of the most fascinating questions facing auditory scientists t...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2010.03.009
更新日期:2010-06-01 00:00:00
abstract::Several advances have been made recently in characterizing neural progenitor cells. In vertebrates, multipotential stem cells have been demonstrated in the developing forebrain both in vitro and in vivo, and a class of stem cells has been identified in the adult CNS. Factors that regulate the proliferation and differe...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(96)80003-1
更新日期:1996-02-01 00:00:00