The gain in brain: novel imaging techniques and multiplexed proteomic imaging of brain tissue ultrastructure.

abstract：:Facial interactions are prominent behaviors in primates. Primate facial signaling, which includes the expression of emotions, mimicking of facial movements, and gaze interactions, is visually dominated. Correspondingly, in primate brains an elaborate network of face processing areas exists within visual cortex. But ot...

journal_title：Current opinion in neurobiology

authors： Brecht M,Freiwald WA

更新日期：2012-04-01 00:00:00

abstract：:Our understanding of the central nervous system (CNS) development has been strongly enhanced by the recent progress of single-cell multiomics approaches. Certainly, the multiplex profiling of individual cell epigenomes and transcriptomes together with dynamic lineage tracing systems brings encouraging new perspectives...

journal_title：Current opinion in neurobiology

authors： Solanelles-Farré L,Telley L

更新日期：2020-11-07 00:00:00

abstract：:Endo-lysosomal pathways are essential in maintaining protein homeostasis in the cell. Numerous genes in the endo-lysosomal pathways have been found to associate with neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia (FTD). Mutations of these genes lea...

journal_title：Current opinion in neurobiology

authors： Wang C,Telpoukhovskaia MA,Bahr BA,Chen X,Gan L

更新日期：2018-02-01 00:00:00

abstract：:Schizophrenia remains a daunting challenge for efforts aimed at identifying fundamental pathophysiological processes and to develop evidence-based effective treatments and interventions. One reason for the lack of progress lies in the fact that the pathophysiology of schizophrenia has been predominantly conceived in t...

journal_title：Current opinion in neurobiology

authors： Uhlhaas PJ

更新日期：2013-04-01 00:00:00

abstract：:Central pattern generators are subject to extensive modulation that generates flexibility in the rhythmic outputs of these neural networks. The effects of neuromodulators interact with one another, and modulatory neurons are themselves often subject to modulation, enabling both higher order control and indirect intera...

journal_title：Current opinion in neurobiology

authors： Dickinson PS

更新日期：2006-12-01 00:00:00

abstract：:Interfacing the nervous system with devices able to efficiently record or modulate the electrical activity of neuronal cells represents the underlying foundation of future theranostic applications in neurology and of current openings in neuroscience research. These devices, usually sensing cell activity via microelect...

journal_title：Current opinion in neurobiology

authors： Scaini D,Ballerini L

更新日期：2018-06-01 00:00:00

abstract：:For many years, it has been postulated that interactions between motor commands and somatic perception in the sensorimotor cortices exist, but they have been difficult to demonstrate. Recent studies have made demonstration of this interaction easier and suggest that cortical activity related to somatic sensation and p...

journal_title：Current opinion in neurobiology

authors： Nelson RJ

更新日期：1996-12-01 00:00:00

abstract：:Thermal information about skin surface temperature is a key sense for the perception of object identity and valence. The identification of ion channels involved in the transduction of thermal changes has provided a genetic access point to the thermal system. However, from sensory specific 'labeled-lines' to multimodal...

journal_title：Current opinion in neurobiology

authors： Bokiniec P,Zampieri N,Lewin GR,Poulet JF

更新日期：2018-10-01 00:00:00

abstract：:The decision to urinate is a social behavior that is calculated multiple times a day. Many animals perform urine scent-marking which broadcasts their pheromones to regulate the behavior of others and humans are trained at an early age to urinate only at a socially acceptable time and place. The inability to control wh...

journal_title：Current opinion in neurobiology

authors： Mukhopadhyay S,Stowers L

更新日期：2020-02-01 00:00:00

abstract：:Presynaptic nerve terminals release neurotransmitter synchronously, asynchronously or spontaneously. During synchronous neurotransmission release is precisely coupled to action potentials, in contrast, asynchronous release events show only loose temporal coupling to presynaptic activity whereas spontaneous neurotransm...

journal_title：Current opinion in neurobiology

authors： Chanaday NL,Kavalali ET

更新日期：2018-08-01 00:00:00

abstract：:Processing of auditory information requires constant adjustment due to alterations of the environment and changing conditions in the nervous system with age, health, and experience. Consequently, patterns of activity in cortical networks have complex dynamics over a wide range of timescales, from milliseconds to days ...

journal_title：Current opinion in neurobiology

authors： Froemke RC,Schreiner CE

更新日期：2015-12-01 00:00:00

abstract：:Standard economic theories conceive homo economicus as a rational decision maker capable of maximizing utility. In reality, however, people tend to approximate optimal decision-making strategies through a collection of heuristic routines. Some of these routines are driven by emotional processes, and others are adjuste...

journal_title：Current opinion in neurobiology

authors： Lee D

更新日期：2006-04-01 00:00:00

abstract：:Social experiences throughout life influence gene expression and behavior, however, early in development these influences have a particularly profound effect. In mammals, mother-infant interactions are the primary source of social stimulation and result in long-term changes in offspring phenotype. This has previously ...

journal_title：Current opinion in neurobiology

authors： Champagne FA,Curley JP

更新日期：2005-12-01 00:00:00

abstract：:Fear and anxiety are debilitating conditions that affect a significant number of individuals in their lifetimes. Understanding underlying mechanisms of these disorders affords us the possibility of therapeutic intervention. Such clarity in terms of mechanism and intervention can only come from an amalgamation of resea...

journal_title：Current opinion in neurobiology

authors： Dias BG,Banerjee SB,Goodman JV,Ressler KJ

更新日期：2013-06-01 00:00:00

abstract：:The anterior cingulate cortex (ACC) and adjacent areas of the medial frontal cortex (MFC) have been implicated in monitoring behaviour and in detecting errors. Recent evidence, however, suggests that the ACC not only registers the occurrence of errors but also represents other aspects of the reinforcement history that...

journal_title：Current opinion in neurobiology

authors： Rushworth MF,Buckley MJ,Behrens TE,Walton ME,Bannerman DM

更新日期：2007-04-01 00:00:00

abstract：:The circuitry mediating the integration of reward perception and adaptive behavioral responses has been further refined. Recent developments indicate that the nucleus accumbens has a primary role in motivational circuitry, whereas afferents to the nucleus accumbens, in part, subserve distinct functions. Dopaminergic a...

journal_title：Current opinion in neurobiology

authors： Kalivas PW,Nakamura M

更新日期：1999-04-01 00:00:00

abstract：:This article reviews recent evidence suggesting that endogenous ciliary neurotrophic factor may be involved in neural responses to injury, and discusses the possibility that ciliary neurotrophic factor could have therapeutic applications in a clinical setting. The functional relevance of ciliary neurotrophic factor in...

journal_title：Current opinion in neurobiology

authors： Adler R

更新日期：1993-10-01 00:00:00

abstract：:Analyzing data from experiments involves variables that we neuroscientists are uncertain about. Efficiently calculating with such variables usually requires Bayesian statistics. As it is crucial when analyzing complex data, it seems natural that the brain would "use" such statistics to analyze data from the world. And...

journal_title：Current opinion in neurobiology

authors： Kording KP

更新日期：2014-04-01 00:00:00

abstract：:Metabotropic L-glutamate receptors are involved in various forms of synaptic plasticity in the hippocampus. The use of a new antagonist (LY341495) that blocks all known metabotropic L-glutamate receptors in the brain, together with subtype-selective antagonists, has identified multiple roles both for cloned and novel ...

journal_title：Current opinion in neurobiology

authors： Bortolotto ZA,Fitzjohn SM,Collingridge GL

更新日期：1999-06-01 00:00:00

abstract：:Identification of genetic mutations linked to familial neurodegenerative diseases have made it possible to generate useful transgenic animal models. Studies using these transgenic animals indicate that many familial neurodegenerative diseases, such as motor neuron disease, Alzheimer's disease, prion diseases and trinu...

journal_title：Current opinion in neurobiology

authors： Lee MK,Borchelt DR,Wong PC,Sisodia SS,Price DL

更新日期：1996-10-01 00:00:00

abstract：:For many years pathophysiological studies on patients with movement disorders were viewed as inferior to those in animal models because, given the complexity of dealing with the complete interconnected CNS, it was difficult to assign any particular physiological abnormality exclusively to the site of a known lesion. M...

journal_title：Current opinion in neurobiology

authors： Rothwell JC,Huang YZ

更新日期：2003-12-01 00:00:00

abstract：:Synapses are specialized sites of cell contact that mediate information flow between neurons and their targets. Genetic screens in the nematode C. elegans have led to the discovery of a number of molecules required for synapse patterning and assembly. Recent studies have demonstrated the importance of guidepost cells ...

journal_title：Current opinion in neurobiology

authors： Margeta MA,Shen K,Grill B

更新日期：2008-02-01 00:00:00

abstract：:Molecular mechanisms involved in the various stages of transmitter secretion have been studied by perturbing the composition of secretory cells using pharmacological and biochemical agents. An emerging approach is to reconstitute individual steps or the entire sequence of secretion mechanisms in non-secretory cells by...

journal_title：Current opinion in neurobiology

authors： Alder J,Poo MM

更新日期：1993-06-01 00:00:00

abstract：:Recent advances in neural and behavioural pharmacology, and in intracellular recording suggest that arousal during the awake state may be regulated by multiple, interdependent neurotransmitter systems that originate in the brainstem or hypothalamus, and project to subcortical and cortical sites. We discuss efforts to ...

journal_title：Current opinion in neurobiology

authors： Marrocco RT,Witte EA,Davidson MC

更新日期：1994-04-01 00:00:00

abstract：:Expression of vnd in ventral, ind in intermediate, and msh in dorsal columns of fly neurectoderm, and of homologous gene families in corresponding domains of vertebrate neurectoderm, suggests that elements of dorsoventral neural patterning have been evolutionarily conserved. However, upstream signaling pathways regula...

journal_title：Current opinion in neurobiology

authors： Cornell RA,Ohlen TV

更新日期：2000-02-01 00:00:00

abstract：:Increasingly systematic approaches to quantifying receptive fields in primary visual cortex, combined with inspired ideas about functional circuitry, non-linearities, and visual stimuli, are bringing new interest to classical problems. This includes the distinction and hierarchy between simple and complex cells, the m...

journal_title：Current opinion in neurobiology

authors： Bair W

更新日期：2005-08-01 00:00:00

abstract：:Neocortex expansion in development and evolution reflects an increased and prolonged activity of neural progenitor cells. Insight into key aspects of the underlying cell biology has recently been obtained. First, the restriction of apical progenitors to undergo mitosis at the ventricular surface is overcome by generat...

journal_title：Current opinion in neurobiology

authors： Wilsch-Bräuninger M,Florio M,Huttner WB

更新日期：2016-08-01 00:00:00

abstract：:Powerful advances in neuroimaging techniques have added to and refined classical descriptions of the neurobiology of language in adults. Recent studies have employed these methodologies to study the nature and extent of plasticity of language-relevant aspects of cerebral organization in adults, in early and late bilin...

journal_title：Current opinion in neurobiology

authors： Neville HJ,Bavelier D

更新日期：1998-04-01 00:00:00

abstract：:In order to understand how brain activity produces adaptive behavior we need large-scale, high-resolution recordings of neuronal activity. Fluorescent genetically encoded voltage indicators (GEVIs) offer the potential for these recordings to be performed chronically from targeted cells in a minimally invasive manner. ...

journal_title：Current opinion in neurobiology

authors： Platisa J,Pieribone VA

更新日期：2018-06-01 00:00:00

abstract：:Over the past year, evidence has accrued that adult CNS stem cells are a widespread progenitor cell type. These cells may normally replace neurons and/or glia in the adult brain and spinal cord. Advances have been made in understanding the signals that regulate stem cell proliferation and differentiation. A deeper und...

journal_title：Current opinion in neurobiology

authors： Temple S,Alvarez-Buylla A

更新日期：1999-02-01 00:00:00