Visual receptive field organization.

abstract：:Cerebellar long-term depression is a persistent, input-specific attenuation of the parallel fiber-Purkinje neuron synapse induced by co-activation of parallel fibers and climbing fibers. This phenomenon endows the Purkinje neuron with a powerful associative computational ability. Recent investigations have provided st...

journal_title：Current opinion in neurobiology

authors： Linden DJ,Connor JA

更新日期：1993-06-01 00:00:00

abstract：:Plasma membrane neurotransmitter transporters for monoamines, GABA, glycine and excitatory amino acids are homologous to two sizable families of bacterial amino acid transporters. Recently, a high resolution structure was determined for a thermophilic glutamate transporter. Also, a bacterial tryptophan transporter rel...

journal_title：Current opinion in neurobiology

authors： Sonders MS,Quick M,Javitch JA

更新日期：2005-06-01 00:00:00

abstract：:Discoveries in modern human neuroscience are increasingly driven by quantitative understanding of complex data. Data-intensive approaches to modeling have promise to dramatically advance our understanding of the brain and critically enable neuroengineering capabilities. In this review, we provide an accessible primer ...

journal_title：Current opinion in neurobiology

authors： Brunton BW,Beyeler M

更新日期：2019-10-01 00:00:00

abstract：:Vertebrates are remarkable for their ability to select and execute goal-directed actions: motor skills critical for thriving in complex, competitive environments. A key aspect of a motor skill is the ability to execute its component movements over a range of speeds, amplitudes and frequencies (vigor). Recent work has ...

journal_title：Current opinion in neurobiology

authors： Dudman JT,Krakauer JW

更新日期：2016-04-01 00:00:00

abstract：:Visual perception is inherently statistical: brains exploit repeating features of natural scenes to disambiguate images that could, in principle, have many causes. A clear case for the relevance of statistical inference in vision is animal camouflage. Although visual scenes are each composed of unique arrangements of ...

journal_title：Current opinion in neurobiology

authors： Reiter S,Laurent G

更新日期：2020-02-01 00:00:00

abstract：:Interfacing the nervous system with devices able to efficiently record or modulate the electrical activity of neuronal cells represents the underlying foundation of future theranostic applications in neurology and of current openings in neuroscience research. These devices, usually sensing cell activity via microelect...

journal_title：Current opinion in neurobiology

authors： Scaini D,Ballerini L

更新日期：2018-06-01 00:00:00

abstract：:Enduring social bonds play an essential role in human society. These bonds positively affect psychological, physiological, and behavioral functions. Here, we review the recent literature on the neurobiology, particularly the role of oxytocin and dopamine, of pair bond formation, bond disruption, and social buffering e...

journal_title：Current opinion in neurobiology

authors： Lieberwirth C,Wang Z

更新日期：2016-10-01 00:00:00

abstract：:Over the past year, evidence has accrued that adult CNS stem cells are a widespread progenitor cell type. These cells may normally replace neurons and/or glia in the adult brain and spinal cord. Advances have been made in understanding the signals that regulate stem cell proliferation and differentiation. A deeper und...

journal_title：Current opinion in neurobiology

authors： Temple S,Alvarez-Buylla A

更新日期：1999-02-01 00:00:00

abstract：:Though many neuronal cell fate decisions result in reproducible outcomes, stochastic choices often lead to spatial randomization of cell subtypes. This is often the case in sensory systems where expression of a specific sensory receptor gene is selected randomly from a set of possible outcomes. Here, we describe recen...

journal_title：Current opinion in neurobiology

authors： Johnston RJ Jr,Desplan C

更新日期：2008-02-01 00:00:00

abstract：:Learning is essential for animal survival under changing environments. Even in its simplest form, learning involves interactions between a handful of neuronal circuits, hundreds of neurons and many thousand synapses. In this review I will focus on habituation - a form of non-associative learning during which organisms...

journal_title：Current opinion in neurobiology

authors： López-Schier H

更新日期：2019-02-01 00:00:00

abstract：:Coordinated excitatory and inhibitory activity is required for proper brain functioning. Recent computational and experimental studies have demonstrated that activity patterns in recurrent cortical networks are dominated by inhibition. Whereas previous studies have suggested that inhibitory plasticity is important for...

journal_title：Current opinion in neurobiology

authors： Herstel LJ,Wierenga CJ

更新日期：2020-08-24 00:00:00

abstract：:Biochemical and physiological evidence has suggested that myosins, both conventional and unconventional, are critical for neurosensory activities. In the past few years, this premise has been supported by genetic evidence that has shown that unconventional myosins are essential for the proper functioning of neurons, r...

journal_title：Current opinion in neurobiology

authors： Hasson T,Mooseker MS

更新日期：1997-10-01 00:00:00

abstract：:The behavioral repertoire of an organism can be highly diverse, spanning from social to defensive. How an animal efficiently switches between distinct behaviors is a fundamental question whose inquiry will provide insights into the mechanisms that are necessary for an organism's survival. Previous work aimed at identi...

journal_title：Current opinion in neurobiology

authors： Rozeske RR,Herry C

更新日期：2018-10-01 00:00:00

abstract：:Neurofilaments are proteins selectively expressed in the cytoskeleton of neurons, and increased levels are a marker of damage. Elevated neurofilament levels can serve as a marker of ongoing disease activity as well as a tool to measure response to therapeutic intervention. The potential utility of neurofilaments has d...

journal_title：Current opinion in neurobiology

authors： Gordon BA

更新日期：2020-04-01 00:00:00

abstract：:Recent findings suggest that cerebral laterality will not be understood in terms of simple dichotomies, such as the idea that the left hemisphere is analytic and the right holistic. Rather, hemisphere differences can be better explained in terms of relatively specific principles that extend over limited domains. For v...

journal_title：Current opinion in neurobiology

authors： Brown HD,Kosslyn SM

更新日期：1993-04-01 00:00:00

abstract：:In vivo tau imaging allows a deeper understanding of tau deposition in the brain, providing insights into the causes, diagnosis and treatment of primary and secondary tauopathies such as Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, chronic traumatic encephalopathy, and some variants of f...

journal_title：Current opinion in neurobiology

authors： Villemagne VL,Okamura N

更新日期：2016-02-01 00:00:00

abstract：:The plasticity of the nervous system is due to the ability of neurons to change their properties by altering the function of their proteome. A major mechanism for this is through altering the amount of proteins by regulating their translation. In this review, we focus on recent advances in the elucidation of the mecha...

journal_title：Current opinion in neurobiology

authors： Sossin WS,Lacaille JC

更新日期：2010-08-01 00:00:00

abstract：:Glioblastoma (GBM) are aggressive and therapy-resistant brain tumours driven by glioma stem-like cells (GSCs). GSC behaviour is controlled by the microenvironment, or niche, in which the cells reside. It is well-established that the vasculature is a key component of the GSC niche, which drives maintenance in the tumou...

journal_title：Current opinion in neurobiology

authors： Brooks LJ,Parrinello S

更新日期：2017-12-01 00:00:00

abstract：:Selective transport of transmembrane proteins to different intracellular compartments often involves the recognition of sorting signals in the cytosolic domains of the proteins by components of membrane coats. Some of these coats have as their key components a family of heterotetrameric adaptor protein (AP) complexes ...

journal_title：Current opinion in neurobiology

authors： Guardia CM,De Pace R,Mattera R,Bonifacino JS

更新日期：2018-08-01 00:00:00

abstract：:Synapses are functional units of the nervous system, through which information is transferred between neurons. The development and activity-dependent modification of synapses require temporally and spatially controlled modulation of gene expression. microRNAs (miRNAs) have emerged as essential regulators of gene expre...

journal_title：Current opinion in neurobiology

authors： Hu Z,Li Z

更新日期：2017-08-01 00:00:00

abstract：:Identification of genetic mutations linked to familial neurodegenerative diseases have made it possible to generate useful transgenic animal models. Studies using these transgenic animals indicate that many familial neurodegenerative diseases, such as motor neuron disease, Alzheimer's disease, prion diseases and trinu...

journal_title：Current opinion in neurobiology

authors： Lee MK,Borchelt DR,Wong PC,Sisodia SS,Price DL

更新日期：1996-10-01 00:00:00

abstract：:Smooth-pursuit eye movements are used to stabilize the image of a moving object of interest on the fovea, thus guaranteeing its high-acuity scrutiny. Such movements are based on a phylogenetically recent cerebro-ponto-cerebellar pathway that has evolved in parallel with foveal vision. Recent work has shown that a netw...

journal_title：Current opinion in neurobiology

authors： Thier P,Ilg UJ

更新日期：2005-12-01 00:00:00

abstract：:Dendritic spines are small actin-rich protrusions on the surface of dendrites whose morphological and molecular plasticity play key roles in learning and memory. Both the form and function of spines are critically dependent on the actin cytoskeleton. However, new research, using electron microscopy and live-cell super...

journal_title：Current opinion in neurobiology

authors： Dent EW,Merriam EB,Hu X

更新日期：2011-02-01 00:00:00

abstract：:The study of plasticity in the central nervous system is a major and very dynamic neuroscience research field with enormous clinical potential. Considerable advances in this field have been made during the past 10 years. It now appears that most circuits in the brain and spinal cord show plasticity and that they can b...

journal_title：Current opinion in neurobiology

authors： Schouenborg J

更新日期：2004-12-01 00:00:00

abstract：:The issue of whether encoding of geometric information for navigational purposes crucially depends on environmental experience or whether it is innately predisposed in the brain has been recently addressed in controlled rearing studies. Non-human animals can make use of the geometric shape of an environment for spatia...

journal_title：Current opinion in neurobiology

authors： Vallortigara G,Sovrano VA,Chiandetti C

更新日期：2009-02-01 00:00:00

abstract：:Animal life is rhythmic. Here we provide an overview of various rhythmic behaviors, connected environmental factors and endogenous mechanisms. We not only cover terrestrial species, but also highlight aquatic environments with typically complex interconnected rhythms. We further address diel, seasonal and potential lu...

journal_title：Current opinion in neurobiology

authors： Häfker NS,Tessmar-Raible K

更新日期：2020-02-01 00:00:00

abstract：:Tight control of developmental timing is pivotal to many major processes in developmental biology, such as patterning, fate specification, cell cycle dynamics, cell migration and connectivity. Temporal change in these ontogenetic sequences is known as heterochrony, a major force in the evolution of body plans and orga...

journal_title：Current opinion in neurobiology

authors： Bielen H,Pal S,Tole S,Houart C

更新日期：2017-02-01 00:00:00

abstract：:Our understanding of the gut system has been revolutionized over the past decade, in particular regarding its role in immune control and psychological regulation. The vagus nerve is a crucial link between gut and brain, transmitting diverse gut-derived signals, and has been implicated in many gastrointestinal, neurolo...

journal_title：Current opinion in neurobiology

authors： Yu CD,Xu QJ,Chang RB

更新日期：2020-06-01 00:00:00

abstract：:How does auditory cortex represent auditory stimuli, and how do these representations contribute to behavior? Recent experimental evidence suggests that activity in auditory cortex consists of sparse and highly synchronized volleys of activity, observed both in anesthetized and awake animals. Many neurons are capable ...

journal_title：Current opinion in neurobiology

authors： Hromádka T,Zador AM

更新日期：2009-08-01 00:00:00

abstract：:Recent work has helped reconcile puzzling results from brainstem transection studies first performed over 60 years ago, which suggested the existence of a sleep-promoting system in the medullary brainstem. It was specifically shown that GABAergic neurons located in the medullary brainstem parafacial zone (PZGABA) are ...

journal_title：Current opinion in neurobiology

authors： Anaclet C,Fuller PM

更新日期：2017-06-01 00:00:00